Protein Alignment FMRFaR and H23L24.4

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_501495.2
• Gene: H23L24.4 / 186764
• WormBaseID: WBGene00019231
• Length: 356
• Species: Caenorhabditis elegans
• Alignment Length: 359
• Identity: 82/359 - (22%)
• Similarity: 150/359 - (41%)
• Gaps: 68/359 - (18%)

  Fly   111 IEFW----VCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGI 171
            :..|    |||:        |::.||..:|:....:....:..|:. |:.||.:.:..|.|:..:
 Worm    16 LNLWLLPLVCGI--------GLILNICCLIVFFSTRGHPLVPALIF-LSFCDCLQLFFSFLVLFL 71

  Fly   172 PSIY------PYTGHFFGYYNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARA 230
            |:::      ||:.  .|...|:   .:..:.|:.:....|||:....::::|:.|:..||.:.:
 Worm    72 PALHDFSQSTPYSA--LGQLAYL---STGLLSPLLLTFNCASIWTICFISIQRHRAILRPLSSIS 131

  Fly   231 LCTYGRAKIYFIVCVCFSLAYNMPR------FWEVLTVTYPEPGKD---VILHCVRPSRLRRSET 286
            ..:.....:.||..:  :|.:|..:      ||.    ..|....|   ::.|  .||.|.|:|.
 Worm   132 SPSKPFKPLLFISLM--ALMFNGCKWAEFRWFWS----HDPTNSSDYQYILAH--EPSDLARNEN 188

  Fly   287 YINIYIHWCYLIVNYIIPFLTLAILNCLIYRQV--KRANRERQRLSRSEKREIGLATMLLCVVIV 349
            |..:..:..|.::.|::|.|.|::||..|...:  :|.:.:.:.....|:|.:   |:|:.:|.:
 Worm   189 YHRVLDNLLYPLLVYLVPLLLLSVLNFRILSNISNRRVSFDHKSRFAQERRSV---TLLISIVTM 250

  Fly   350 FFMLNFLPLV--------LNISEAFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFK--RIF 404
            ||:.:...|.        .|.||.|....|     :.|||..:.|..|.|:|.:|..:|:  |..
 Worm   251 FFLCHTGGLAYRFVDQEKYNNSELFVLLKD-----VINLLFNVYSFTNPLLYFVFTRQFRDLRTM 310

  Fly   405 LLIFFKRRLSRDQPDLIHYESSISNNGDGTLNHR 438
            ....|....||.       ||....|......||
 Worm   311 WNSHFASPASRS-------ESYAITNSKPNSKHR 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	74/320 (23%)
		TM helix 1	115..141	CDD:410630	7/25 (28%)
		TM helix 2	147..172	CDD:410630	6/24 (25%)
		TM helix 3	193..223	CDD:410630	6/29 (21%)
		TM helix 4	235..255	CDD:410630	4/19 (21%)
		TM helix 5	289..314	CDD:410630	7/24 (29%)
		TM helix 6	334..362	CDD:410630	7/35 (20%)
		TM helix 7	372..397	CDD:410630	7/24 (29%)
H23L24.4	NP_501495.2	7tm_GPCRs	24..306	CDD:475119	72/311 (23%)
		TM helix 2	49..70	CDD:410628	6/21 (29%)
		TM helix 3	95..117	CDD:410628	4/21 (19%)
		TM helix 4	138..159	CDD:410628	4/22 (18%)
		TM helix 5	192..215	CDD:410628	6/22 (27%)
		TM helix 6	241..263	CDD:410628	6/24 (25%)
		TM helix 7	276..301	CDD:410628	8/29 (28%)