Protein Alignment FMRFaR and sprr-2

DIOPT Version :10

• Sequence 1: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_510455.2
• Gene: sprr-2 / 181575
• WormBaseID: WBGene00009629
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 448
• Identity: 106/448 - (23%)
• Similarity: 189/448 - (42%)
• Gaps: 92/448 - (20%)

  Fly    51 VRYDLFPQN-NSQPTLQIVLNHTE--VQTDLQYPHYEDLGLDPDPNWTRIC-EDVY-NPLLENNR 110
            :.|:::..| :::|....|....|  |:.|..|       .|   ..:|.| :|.| .||.:.:.
 Worm     1 MNYEVYCGNAHAEPNSSAVQQLAEACVEQDASY-------FD---GCSRTCVKDKYLLPLTQFDN 55

  Fly   111 IEFWVCGVLINIVGVLGILGNIISMIILSRPQMRSSINYLLTGLARCDTVLIITSILLFGIPSIY 175
            :|..|.|.:..|:.:..:..|....::||:..|.:..|.:|..:|       |..:|:..:|  .
 Worm    56 LEIVVYGQIFPILVLFAVFANAAVALVLSKKHMITPTNVVLKYMA-------IAELLVGLVP--L 111

  Fly   176 PYTGHFFGYYN------------YVYPFISPAVFPI-GMIAQTASIYMTFTVTLERYVAVCHPLK 227
            |:|..||...|            |:..:...|..|: .|||    :::|..:..:|||::.|||.
 Worm   112 PWTLFFFSMGNIKETHRLELWWCYLQKYSMDAFPPVFHMIA----MWLTVLLAAQRYVSISHPLH 172

  Fly   228 ARALCTYGRAKIYFIVCVCFSLAYNMPRF--WEVLTV---TYPEPGKDVILHCV-RPSRLRRS-- 284
            :|:.|.....::..::....|....:|:.  :|..||   .|..........|| .|:.:..:
 Worm   173 SRSACNVKNVRLATMIITVTSFLCGLPKSFDYEYETVHGWIYSHGNWTYASSCVMMPTAILTNMG 237

  Fly   285 -ETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQRLSRSEKRE--------IGLA 340
             ..|.|||. |...:...|:|...|.:||.|:.:.::||.|.:.||.|.::.|        ...:
 Worm   238 QTVYFNIYF-WTRALGFIILPSFLLVLLNGLLIKGIRRAQRRKLRLLREKRSEEAARQRDSNSTS 301

  Fly   341 TMLLCVVIVFFMLNFLPL-----VLNISEAFYSTIDHKITK---------ISNLLITINSSVNFL 391
            .||:.:|.:|.::| ||.     :|.:.|.|  ||...|.:         .||:::.....:||.
 Worm   302 LMLVAIVSIFLIVN-LPQAIFMGLLCVCETF--TIKIPILEGTFPAVFLIASNMIVIATYPINFG 363

  Fly   392 IYIIFGEKFKRIFLLIF--------FKRRL--------SRDQPDLIHYESSISNNGDG 433
            ||......|::.|.|:|        .:||:        ||.:.|:..:..::..|.:|
 Worm   364 IYCFMSSSFRQTFKLLFCPGASQLQCERRIEAASAVHSSRRRSDICSHLVNVCTNSEG 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	80/333 (24%)
		TM helix 1	115..141	CDD:410630	6/25 (24%)
		TM helix 2	147..172	CDD:410630	5/24 (21%)
		TM helix 3	193..223	CDD:410630	9/30 (30%)
		TM helix 4	235..255	CDD:410630	1/19 (5%)
		TM helix 5	289..314	CDD:410630	9/24 (38%)
		TM helix 6	334..362	CDD:410630	9/40 (23%)
		TM helix 7	372..397	CDD:410630	7/33 (21%)
sprr-2	NP_510455.2	7tmA_FMRFamide_R-like	59..376	CDD:410630	80/333 (24%)
		TM helix 1	60..86	CDD:410630	6/25 (24%)
		TM helix 2	92..117	CDD:410630	8/33 (24%)
		TM helix 3	138..168	CDD:410630	9/33 (27%)
		TM helix 4	180..200	CDD:410630	1/19 (5%)
		TM helix 5	242..267	CDD:410630	9/25 (36%)
		TM helix 6	295..325	CDD:410630	7/30 (23%)
		TM helix 7	344..369	CDD:410630	6/24 (25%)