|
Fly 242 DNGP-QPPQTQPHLQLKSGFEPFSKLPSFQSQFHGFNEQLLPDGTPMPVPIGAG----VPPGSAA 301
|:.| |..|..|.::...|.:..|.|.....:...|..|.:.| :.:.:|..:| :.||...
Human 156 DSVPMQDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVED-SKINIPTHSGPAAEILPGPLE 219
Fly 302 AVAAATGSIPPGSVGPNSVAGPVGPTAMSSLQTV-AMSPASISVSSPGMMSVGSPLTQLSSLQT- 364
......|.....::...| |...|.:..|| |..|.. ::|.:.|.|:|..||..|.:
Human 220 GTRCGEGLFSEETLNDTS-----GSPKMFAQDTVCAPFPQR---ATPKVTSQGNPSIQLEELGSR 276
Fly 365 -------------------------------------------SITPPS------AGSFPA---- 376
|.:|.| |||..|
Human 277 VESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGA 341
Fly 377 -PPPPNAF---AHHHALN-------------PHHH--------HRGASGYPTPYAELPLYPGFTP 416
|....|| |:...:: ||.. |..|.| .|| :||..||..|
Human 342 KPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALG-ETP--DLPEIPGAIP 403
Fly 417 LSVKKEPISGGSDFEMLL-KKEDFDLSNSGGAGL-IHHPLQHGQPHPIPMGMHTPTSYDGNNSNN 479
:. |..|..:| ::|...:|.|....| :..|: .|:||.. .:.|:.:....|..
Human 404 VQ--------GEVFGTILDQQETLGMSGSVVPDLPVFLPV---PPNPIAT-FNAPSKWPEPQSTV 456
Fly 480 SYPQAAGG-------GSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRPNSL 537
||..|..| ||| |||.:::.. ||....|:..: :::
Human 457 SYGLAVQGAIQILPLGSG-HTPQSSSNS-----------EKNSLPPVMAI------------SNV 497
Fly 538 ESSAESEASGMDVDPSNPGQVDAVSSTANFKSPL--------SALGMGDSNDANASGCDKQDYGR 594
|:..:...|.: |:| |..| || ::||:...:.| |..|.|.|.
Human 498 ENEKQVHISFL---PAN---------TQGF--PLAPERGLFHASLGIAQLSQA---GPSKSDRGS 545
Fly 595 RHHLPPPT---LNHPPMTLPPPTITITPTTHNHNHQNHNHNHSNDNNSSSCSLFQS--KKKRKRC 654
.......| :|...:|:|.|.: :.::||..:|..: |||||||
Human 546 SQVSVTSTVHVVNTTVVTMPVPMV-------------------STSSSSYTTLLPTLEKKKRKRC 591
Fly 655 GECVGCQRKDNCGECAPCRNDK-SHQICKQRRCEKLTEK-----------------KEPKAKTIV 701
|.|..||:|.|||||..|:|.| ||||||:|:||:|.:| :|.|.|.:.
Human 592 GVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLK 656
Fly 702 FGADGQPVR-PDSKR------GRGKGKSSGSGNGTV--------NATGIAAGNGT---------- 741
...|.:||. |.|:. |.|:.:.......|| :.|||.....|
Human 657 ADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDH 721
Fly 742 -------------PTTGSRARKNSTKANKLNAAAASATSPRLSPVPAATLLPQQSPNTTSATGNL 793
.:..|...|..||:.||...........:..:||.|.:..:..|.......|
Human 722 VKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTL 786
Fly 794 QQQQQQQQQQYQQHQQLLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQ 858
:....:..:....|:..:| .:.:.....:.:.:.....| ||.......:|...|.
Human 787 ENNSYKFLKDTANHKNAMS--SVATDMSCDHLKGRSNVLVF--------QQPGFNCSSIPHSSHS 841
Fly 859 IT---AQIQTMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYA 920
|. |.|....|||:.| :.||...|
Human 842 IINHHASIHNEGDQPKTP-----------------------ENIPSKEP---------------- 867
Fly 921 YPSNGYVQSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAIN-----QVGLQSVAGFAPSYAG 980
:.| :||| ||.:: ::.|:.|. |.....
Human 868 -------KDG-------------SPVQ------------PSLLSLMKDRRLTLEQVV--AIEALT 898
Fly 981 QVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTMS-----GNDTPGYPRVSSVPPRSLNCNGYSGD 1040
|:|.||...|...:.::.::.:|...:.||...: ..|... |.:...||:..:|......
Human 899 QLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQD-PNLQGEPPKLNHCPSLEKQ 962
Fly 1041 -------YSGSPATNSNSNNNSSSNTSNTNN----------------SNASNNNATTVVSGGTTT 1082
::|...|.|||:.||::|.::|.: ||:|..:....::.|..|
Human 963 SSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIIT 1027
Fly 1083 PAPPPTVVAQ--PASSPMQPPNQAVPQSPTRSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQ---- 1141
.......:.| |.::.::..||.:.. |..|.......|..|...::..||.|..|.
Human 1028 LDNCSNDLHQLPPRNNEVEYCNQLLDS----SKKLDSDDLSCQDATHTQIEEDVATQLTQLASII 1088
Fly 1142 -----QQQQQHLSSPPMQDWNWQQQQQQQQSLGGEGYAQGERLHLN-----TRIKSMIMRKSDPK 1196
:.:.:.:.|.|........||:..|..|.........:|.| |:.|:...:|:...
Human 1089 KINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKST 1153
Fly 1197 DPPPDLQQQPQQVQQQQ---QTGHFLSYSHHLRPEAALSANGPS--SATPTHPLPNLQQQQQQVQ 1256
......:::|..|..|: |....|||.:....:..:::...: ...| |..|
Human 1154 PSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCP-HDFP---------- 1207
Fly 1257 QVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIWKP-HHANSFKKPSVV---------SGYPASQDA 1311
.|.|:::: ...|||| ....|..:|..| ..||.|.:.
Human 1208 -------------TVFGKISS------STKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEE 1253
Fly 1312 QLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAAAAAAAAEAAAEI 1376
:::: :|....::.| .|:.|..||. .
Human 1254 KVKV-----EPLDSLSLFH--------------------LKTESNGKAF---------------T 1278
Fly 1377 DRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLGPPQPNKMEGYERNYQ 1441
|:..||... ..::|:...||......||.|
Human 1279 DKAYNSQVQ-----LTVNANQKAHPLTQPSSPPNQ------------------------------ 1308
Fly 1442 NFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQNFQQNF-------VPGY 1499
|.| ...|.....|||..::.. :||.
Human 1309 --------CAN-------------------------VMAGDDQIRFQQVVKEQLMHQRLPTLPGI 1340
Fly 1500 QHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEKDIPAYPIPPHRYALGHGA 1564
.|.| |||.: ||
Human 1341 SHET-----------------------------------PLPES---------------AL---- 1351
Fly 1565 PPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPTAEHLKDGTCLGLG 1629
.|.|....|..|.|...|
Human 1352 ----------------------------------TLRNVNVVCSGGITVVST------------- 1369
Fly 1630 IQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTTDRLEKGNKT 1694
..:|.:.:...|......|..|: |...|....... || |.:.:.....:
Human 1370 --------KSEEEVCSSSFGTSEFSTVDSAQ-KNFNDYAMNFFT-----NP---TKNLVSITKDS 1417
Fly 1695 EIPECEC----FQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGK 1755
|:|.|.| .|.||.| ||||||...|:..:|...|.|....|..:|||.:||||||||
Human 1418 ELPTCSCLDRVIQKDKGP-----YYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGK 1477
Fly 1756 TSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLN 1820
:|.|||:||||:||:..|||:|.:|::|.||.|..|.:||.::.|||:|...||..|..|...|.
Human 1478 SSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLK 1542
Fly 1821 KY-GLPTTRRCATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKFRLSVKSE- 1883
.| |.||.|||..||||||.|||:|||:.|||:|||||||||:||||:.||.:.|:||:...|.
Human 1543 SYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPL 1607
Fly 1884 ------------------------------EAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEH 1918
|..:||::..:||.|||::||..|.:|.||.:||:
Human 1608 HTYYERITKGRNPERRYMKPERISPGHEAMEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYEN 1672
Fly 1919 EASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDTR-LPDDEQFHVL 1982
.|.:||||.:.|:||||||||||||||.|||:|||.:|.||...|.:..||... :|.|||.|||
Human 1673 VARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVL 1737
Fly 1983 PLYTMDGTDEFESVEGQRDKHRTGAVQML----DKFPCEVRVRSTPLIPCRRHGKKRKDGDEAAP 2043
|||.:..||||.|.||...|.::||:::| .|..|..: |..|.|||| ||.
Human 1738 PLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQ-------PVPRSGKKR-----AAM 1790
Fly 2044 PDG---------DQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNANGAS 2099
... ::..:.....:::|: |..|::.||.|.||: |.....
Human 1791 MTEVLAHKIRAVEKKPIPRIKRKNNST------TTNNSKPSSLPTLGS-----------NTETVQ 1838
Fly 2100 SKSKGKGKSNQSNNSSASTPG-SAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGG 2163
.:.|.:.:.:....||.:|.. |..||.|.| ....|| .||..|...| |.|
Human 1839 PEVKSETEPHFILKSSDNTKTYSLMPSAPHP------VKEASP---GFSWSPKTAS-ATP----- 1888
Fly 2164 QGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQW 2228
:.|.|.||....|::..
Human 1889 --------------APLKNDATASCGFSERS---------------------------------- 1905
Fly 2229 PTPHA--PMGMQAQVGGLGGGGPG----GTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAP 2287
.|||. |.|..:........||| |.||.:|.| |.|..:|.:...|:|.:
Human 1906 STPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTL--SAPVMEPLINSEPSTGV--------- 1959
Fly 2288 TGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGG 2352
|.| .||.| |.:..:.:::|....::| .|..:||.:|.:
Human 1960 ------TEP--LTPHQ--------PNHQPSFLTSPQDLASSP----MEEDEQHSEADE------- 1997
Fly 2353 VGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNLTESKLTALTAMQPMTNLAPLTTSH 2417
Human 1998 ----------------------------------------------------------------- 1997
Fly 2418 HPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYG 2482
||||
Human 1998 -----------PPSD-------------------------------------------------- 2001
Fly 2483 MYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAGAGSLISSHGSVASAGVGLQKAMVP 2547
Human 2002 ----------------------------------------------------------------- 2001
Fly 2548 VPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLSNGQTNSDTVAT 2612
Human 2002 ----------------------------------------------------------------- 2001
Fly 2613 PTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPGSTNSTKIEPIGEVAEINENIEAFQ 2677
.|..| .|.|....|:..|.|....:|:| |.
Human 2002 -EPLSD--------------------------------DPLSPAEEKLPHIDEYWSDSEHI--FL 2031
Fly 2678 DPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEK 2742
|..:||||||..|||||||||:.|:||||.|..|:|:||||::|:||||:|||:.:||.:.
Human 2032 DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFEL---- 2092
Fly 2743 MRVKKINTDLDNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSK 2807
||.|.| .::.|| |
Human 2093 -----------NKIKFE------------------------------------AKEAKN-----K 2105
Fly 2808 KKKSSDSKKSQAN---EQSK--NE--KVALH-APTLTTTSWTTLFP---THPCVVSGKY 2855
|.|:|:.|...|| |||. || ::..| |.|||..:..|:.| || |:|.|
Human 2106 KMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTH---VAGPY 2161
| 
