Protein Alignment Tet and tet3

DIOPT Version :10

• Sequence 1: NP_001261344.1
• Gene: Tet / 38347
• FlyBaseID: FBgn0263392
• Length: 2921
• Species: Drosophila melanogaster
• Sequence 2: NP_001314874.1
• Gene: tet3 / 103283056
• ZFINID: ZDB-GENE-060526-109
• Length: 2052
• Species: Danio rerio
• Alignment Length: 2558
• Identity: 625/2558 - (24%)
• Similarity: 913/2558 - (35%)
• Gaps: 931/2558 - (36%)

  Fly   648 KKKRKRCGECVGCQRKDNCGECAPCRNDK-SHQICKQRRCEKLTEKKEPKAKTIVFGADGQPVRP 711
            ||||||||.|..|.||:|||.|:.|.|.| .|||||.|:|::|..||.|.........:.|||.|
Zfish    72 KKKRKRCGVCGPCMRKENCGTCSNCLNRKIGHQICKLRKCDELKRKKSPWEVEYFEDKNTQPVIP 136

  Fly   712 -------------DSKRGRGKGK----------------SSG----------------------- 724
                         |..||:|:.:                |:|
Zfish   137 NLAKETVSVVGSVDGPRGKGQMEIGSHERLEEGLLNQELSNGLSKHASNEENVCDNEDRDATKEQ 201

  Fly   725 ------SGNGTVNAT------------------GIAAGNGTPTTGSRARKNSTKANKLNAAAASA 765
                  .|.|:::.|                  |:.:|....||.:..  :...|..|.|.:..:
Zfish   202 HQHNFHEGAGSISQTPGWVLEHTGKLSNPESQQGVWSGQNASTTVNDV--DMEDAQTLVAFSVGS 264

  Fly   766 TSP----RLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQYQQHQQLLSQQQLLSQQQQQYQQ 826
            ..|    :.||.|.|.|  .:..|...:.|..:.:::.....:...:.|.:.|..||:.:..::.
Zfish   265 LPPYTNHQPSPTPTAQL--YERFNQEMSNGGEEAKKKGVDGAFCPPEDLNTLQAALSKARHGHKP 327

  Fly   827 PQ---------QQQQHFQQQ------------------QQQHLQQQHAQQQHLPQQQHQITAQIQ 864
            |.         ...:..::|                  .||.|:|.|..|.. |||.......:|
Zfish   328 PNCDCDGPDCPDYLEWLEKQIKLVTNCQNKTSCNLSGTAQQPLEQHHYSQSQ-PQQCGGKPLCVQ 391

  Fly   865 TMKDQP--QQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYV 927
            ....||  .:|..|..|.|                  |...|...|:.|:       |...|..:
Zfish   392 DTNPQPLVNKPSTPRPFGP------------------PAPIPCSPSVLSI-------AKERNVSL 431

  Fly   928 QSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQSVAG----FAPSYAGQ----VSA 984
            |:.:..:.                .:|..:|.|..:...|..|:|.    ...||...    ||:
Zfish   432 QTAIAIEA----------------LTQLSATVPQTVVPPGESSLANHHQHLPTSYHQNMPQVVSS 480

  Fly   985 AP-----------VPPSQQQQQQQ----QQQQQQHLGADLNKTM---SGNDTPGYPRVSSVPPRS 1031
            :|           :|.|....||:    :||:.|..|......:   |.:.:..||  ||.||
Zfish   481 SPGPLLSSSATSAIPQSNHYPQQELTTWEQQRPQSKGEAPTANIFPSSSHYSSSYP--SSKPP-- 541

  Fly  1032 LNCNGYSGDYSGSP---------ATNSNSNNNSSSNTSNTNNSNASNNNATTVVSGGTTTPAPPP 1087
                 ::..::.||         .|.|:...||..|.....|:::..:
Zfish   542 -----FTNMHASSPNPRPQQWNQGTASSCEKNSPRNAWMMANTDSKQH----------------- 584

  Fly  1088 TVVAQPASSPMQPPNQAVPQSPTRSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQQQQQQHLSSPP 1152
              .|:|:.....|.::.               :|....|| |..|:..|           ...|.
Zfish   585 --FAKPSHESSDPVSEL---------------KQLLGDTG-GKHPFKFP-----------FPHPS 620

  Fly  1153 MQDW---------NWQQQQQQQQSLGGEGYAQGERLHLNTRIKSMIMRKSDPKDPPPDLQQQPQQ 1208
            :||.         :.:|:.:.::.||.|....|:...||                       .||
Zfish   621 LQDVHKGSFTGMPHIKQEVETKEYLGSECSVMGQEGMLN-----------------------GQQ 662

  Fly  1209 VQQQQQTGHFLSYS------HHLRPEAALSANGPSSATPTH----------------PLPNLQQQ 1251
            ..|.||....:.:|      .||..:..|.:|.|:.....|                .|.|::|:
Zfish   663 QFQGQQLSSTIRHSTQAALQQHLHHKRNLFSNSPTYGPLAHMACQDLRKWWPQTIPENLINIKQE 727

  Fly  1252 QQQVQQVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIWKP-------HHAN------------SFK 1297
            .::.::.:..|....:|.|.|      |.|..|..:.||       |...            :..
Zfish   728 HKEPKKKKGAQSSHLKQPAGG------PFGPLGTPLPKPKPIVIKKHKQKASQPTFLPQIQITIS 786

  Fly  1298 KPSVVS-GYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQ---------PKK 1352
            ||.::| ||..|: |||...|    ||....:     ||....:.||..|.:|         |..
Zfish   787 KPPLISPGYAPSR-AQLVPSL----PGMEAGL-----PPTQVAESHPAPAQSQESIINCSSAPIS 841

  Fly  1353 SRSRSKASRAAAAAAAAAEAAAEIDRDRNSTDPGGGG---------LKPLSAHYPPHPHAAGGPP 1408
            ..|.|..:..:..|.:..:..|         .||..|         :.|.::...|.|..||
Zfish   842 ENSHSSTNPVSVLAPSTQKVIA---------CPGSAGSNDSIPTTSITPQTSTTQPSPSLAG--- 894

  Fly  1409 PGQDYHSQYIKTEPGLLGPPQPNKMEGYERNYQNFIQYADFCQNDGQGQPV--QQHHGHGQQDYA 1471
                         ...|.|.....:..:|..:.:....|.....:|..|||  :.|...||
Zfish   895 -------------LSNLDPKFEELIRQFEEEFGDTAASAAETPENGPVQPVVTESHPNSGQ---- 942

  Fly  1472 GYHHNSAYYGAGASSFQQNFQQNFVPGYQHSTYGARGKPPA-NQPHQIHGHGQSLMELDRKPDTN 1535
                                              .|.:.|: .||                   |
Zfish   943 ----------------------------------LRPESPSLKQP-------------------N 954

  Fly  1536 SIIPLPTNY-------EKDIP-----AYPIPPHRYA----------------------------- 1559
            :..|:|||.       :||||     ..|:||....
Zfish   955 NCPPVPTNESEPMNEGQKDIPERQKEKTPLPPEELCTVKQESEECALDVKPSGELLSEFLKQQNP 1019

  Fly  1560 -LGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGT-RPPTAEHLKD 1622
             :...:||:      ...|||.      ..|...|.:..     .||..|:|.. ..||.:....
Zfish  1020 FVAPFSPPN------KRMKIES------SNGVTVLSTTA-----CFSADREGDDFNTPTKDIFPS 1067

  Fly  1623 GTCLGLGIQPKEELID--EDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTT 1685
            ...|...::.....:|  ...|:||.|..::|
Zfish  1068 SPSLKGFLESPLRYLDTPTKNLLDTPGKDVQP--------------------------------- 1099

  Fly  1686 DRLEKGNKTEIPECEC----FQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEK 1746
                     :.|.|:|    .:.|:.|     ||.|||:...:..:|:..|:|....|..:||||
Zfish  1100 ---------DFPICDCVDQVLEKDEGP-----YYNHLGSGRDIPSVRQLMEDRYGEKGEAVRIEK 1150

  Fly  1747 IVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNA 1811
            :||||:|||:|||||:||||:||:..:||:|.|||:||||.|....|||.::||:|:||...|..
Zfish  1151 VVYTGREGKSSQGCPIAKWVLRRSSEKEKVLCVVKQRPGHHCANTVIVVVILAWEGVPRALGDKL 1215

  Fly  1812 YKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKF 1876
            |:.:...:.|||.||:|||..||:|||||||.|||:.|||:|||||||||:|||||||||..|||
Zfish  1216 YREVTETITKYGNPTSRRCGLNEDRTCACQGKDPETCGASFSFGCSWSMYFNGCKYARSKVPRKF 1280

  Fly  1877 RLSVK--SEEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTAC 1939
            ||..:  .||..:.|:...:||.:||::|::.|::|.||..:|..||||||||:.|:||||:|||
Zfish  1281 RLQGEHPKEEDNLRDNFQALATHVAPLYKKLAPQAYSNQCLHEDVASDCRLGLKEGRPFSGITAC 1345

  Fly  1940 LDFCAHSHRDLHNMQDGCTVHVALLKPGNRDT-RLPDDEQFHVLPLYTMDGTDEFESVEGQRDKH 2003
            :|||||:|:|.||:.:||||...|.|..||.. .:|:|||.||||||.:..||||.|.|.||.|.
Zfish  1346 MDFCAHAHKDQHNLHNGCTVVCTLTKEDNRTVGTIPEDEQLHVLPLYKLATTDEFGSEENQRLKM 1410

  Fly  2004 RTGAVQMLDKFPCEVRVRSTPLIPCRRHGKKRKDGDEAAPPDGDQ--------DAVGDANSQSSS 2060
            :|||:|:|..|..|||....|...||   ::|.:..:||....::        :.......:.:.
Zfish  1411 QTGAIQVLANFRREVRKLPEPAKSCR---QRRLEAKKAASEKKNRKLQLAETPEKTVKMEIRHAE 1472

  Fly  2061 SNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNA-NGA--SSKSKGKGKSN---QSNNSSASTP 2119
            |...|...:|..:|...|.     ||||..:.... |||  ..::.|.||:|   .:.|||.|.|
Zfish  1473 SPHIQQGNKAIPKQEVKPT-----IKKEPVDHFQPFNGAIHGYQALGNGKTNPDPHNMNSSFSYP 1532

  Fly  2120 GSAP----PSTPSPRCQTPVT--------------NNPSPAGSAFSTPPV--HGSNANPQSNGGQ 2164
            |:..    |....|..|.|:.              |.||   ||..:|.:  :...|.|: ||
Zfish  1533 GNYARGRIPGNSHPPAQNPINGFHPNLQDIRYGYYNYPS---SALFSPELLRYDKGAWPK-NG-- 1591

  Fly  2165 GTGNQPGQLMSSNSSLMNMATMIDTFTDAQ-LQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQW 2228
                :|.            |...:...|.| ||:|...:                         :
Zfish  1592 ----EPS------------AQAFEQKPDVQCLQANLAQA-------------------------Y 1615

  Fly  2229 PTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPS------TPT-------------AQPQLGVPP 2274
            ||.|..  .|||:.       ..::.|.|  .||      ||:             .|..:.||.
Zfish  1616 PTHHGQ--SQAQMA-------DASIQGYP--QPSDISQCRTPSMSLEQTHRSKPIVKQEPMDVPL 1669

  Fly  2275 ATSIAGGTTTGAPTGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQ 2339
            ..:.:.|.....||       .|:.|||                          |.|       .
Zfish  1670 YEARSDGQAQSCPT-------TPSTTPT--------------------------PEG-------W 1694

  Fly  2340 HQQAQQQSALTGGVGPGGLPVVGGAPGDLKGRLVSEEN---PDSTTLVNHHHHHHNLTESKLTAL 2401
            |           |..|.|..|..|..|::  |..|..:   ||...|...|.|.|
Zfish  1695 H-----------GHKPNGSLVPKGWDGNI--RAASNNSPFTPDKQRLHQQHQHEH---------- 1736

  Fly  2402 TAMQPMTNLAPLTTSHHPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQ 2466
                                    |:.|.......|:.  ||.....|.|.|.|
Zfish  1737 ------------------------PQYPQQQQWNSYSC--PNTPMASPAPSPSP----------- 1764

  Fly  2467 NMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGS-----ANPA-AGAG 2525
              :...|...|.||:...|:|...|.|.|....|..||       ..|||:     .||| |...
Zfish  1765 --SLKAGLSPAPSPHPSTPRQWGSPAPSPQPKAWGPYG-------PMGYGAGVIRQGNPAGAYPD 1820

  Fly  2526 SLISSHG-SVASAGVGLQK---------AMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQ 2580
            :::|..| :..||.:|||:         |....|.|
Zfish  1821 NMLSQAGVNCGSAPLGLQEKAWKSGGGSAAGSTPSP----------------------------- 1856

  Fly  2581 QQQQVQQLQQEAPQ-TILPDL---SNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAG 2641
                       ||: .:.||.   |:||...|                             |||
Zfish  1857 -----------APEGRLFPDALQRSDGQACWD-----------------------------SGA- 1880

  Fly  2642 AATTAPPIASPGSTNSTKIEPIGEVAEI-NENIEAFQDPQMGGVAIALNHGSVLIECAKHEMHAT 2705
                           .|:.|...|..|: :::...|.||.:||||:|..||.||||||:.|:|||
Zfish  1881 ---------------ETQSERDPEEDEVWSDSEHNFLDPNIGGVAVAPAHGCVLIECARRELHAT 1930

  Fly  2706 TAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGE 2770
            |.:::|||.||:|::|:||||:|||:..||:..||.||::      |..:|::.::
Zfish  1931 TPLKKPDRTHPSRISLVFYQHKNLNQPCHGLALWESKMKI------LAERARQRQQ--------- 1980

  Fly  2771 DMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSKKKKSSDSKKSQANEQSKNEK---VALHA 2832
                  |.||:           ..:.:::|  |.|.|:|.::.| .|.:..|:|:::   |...|
Zfish  1981 ------EAALL-----------GLSQEEIK--AYGKKRKWAAGS-ASPSPGQTKDKREGVVTRMA 2025

  Fly  2833 PTLTTTSWTTLFPTHPCVVSGKY 2855
            ||..:|:..|:.|.....::|.|
Zfish  2026 PTQHSTTIVTVSPYPSTHLTGPY 2048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:366873	25/38 (66%)
		TET	1699..2044	CDD:380671	182/351 (52%)
		Tet_JBP	<2667..2743	CDD:394797	40/76 (53%)
tet3	NP_001314874.1	zf-CXXC	72..111	CDD:366873	25/38 (66%)
		Atrophin-1	<586..>881	CDD:460830	70/369 (19%)
		PHA03247	<745..987	CDD:223021	65/339 (19%)
		Tet_JBP	1104..>1428	CDD:394797	176/328 (54%)
		PRK07764	<1767..1915	CDD:236090	52/239 (22%)
		Tet_JBP	<1889..2020	CDD:394797	57/165 (35%)