Protein Alignment Atg2 and ATG2

DIOPT Version :10

• Sequence 1: NP_647748.1
• Gene: Atg2 / 38344
• FlyBaseID: FBgn0044452
• Length: 1906
• Species: Drosophila melanogaster
• Sequence 2: NP_014157.1
• Gene: ATG2 / 855479
• SGDID: S000005186
• Length: 1592
• Species: Saccharomyces cerevisiae
• Alignment Length: 2141
• Identity: 387/2141 - (18%)
• Similarity: 692/2141 - (32%)
• Gaps: 794/2141 - (37%)

  Fly     1 MSWFNPWDGLKTKMCRYLLQRY--------------LG-----QFFENNLNLEQLKV-DLYNGKA 45
            |:::.| ..::.::..|:||:.              :|     .|.:.||:|:.|.: ::...:.
Yeast     1 MAFWLP-QNIQKRLLLYVLQQISLFSNIDLSNLDVSIGSKSHFSFHDVNLSLDDLNIPNVQINEG 64

  Fly    46 VVEDIFLKVNAFNDLFEDQGWAFEVVSGHI-----GRLTVVVPWNALMTNDSSLEIH-------- 97
            :|:::.||:               .|||.:     |...::.|    :.:..|.|:|
Yeast    65 IVDELVLKL---------------TVSGGVEIDGSGLRFIMTP----LYSSGSQELHSDFLVKSI 110

  Fly    98 -NLTITL----RPVT---RYQSGTTMLESMWSSVSSSMQMAEECMKQVDDDVPFLN--------H 146
             :||.::    .|:|   ||:.     :.:.||.|||     :....::...|..|        .
Yeast   111 QDLTNSMLQFSDPLTTYNRYKE-----DDISSSDSSS-----DLNSNIEASKPAANGSYTLQNMR 165

  Fly   147 NNAL-IGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLVLSFQASHVEYKNKTGYEMPM 210
            |.|| :.|.|....:.:|..|......:.:.||..:...|.:.:.......|:..:|.|     :
Yeast   166 NKALNVALAKLKIALKDVTIRFIVNDRDPSDNIVEVHLESIQLITTDANLRHINIENIT-----I 225

  Fly   211 STSQDTETEEDPNSSFNALPM-----IAKHNLVIEGLSLHTSEVLDVMDHQFGPTPYE------- 263
            |:.|.....:.|...||...:     ::|    :|..||:.|    .|:.|....|.|
Yeast   226 SSIQKQAVPDSPVHPFNNDDLSQSVYLSK----MEATSLYMS----AMEEQSNEDPSEPQVTQEE 282

  Fly   264 ---QLCK--IVELKGAQNIQINIKQTENIVGPKVS-LELSLDDIYFMLTPRQIHLLIEF------ 316
               ..||  ::|:   .|:.|..|...::...::| :.:.:.|::.     .||.::|.
Yeast   283 QENDKCKESLMEI---NNLNIAFKGLSSVNDLRMSNIVIDIQDVHL-----AIHKIVEIKNSTLK 339

  Fly   317 ------------SKGFNCGGQQERPKKGRSLKSAPPSEYQMHSLQQPTRMTGI--------LGQN 361
                        ::.|:|...|          |..|.:      |:|:.::.:        |||:
Yeast   340 NIIDIIVTHLDANESFSCQDSQ----------SPSPDK------QEPSALSSVDIKCIYLNLGQD 388

  Fly   362 ADWCTGMSEADPSEYSVYGNPPRSGYARSRKMSESTNSMVTSCTNTLQQELG--YTEKSGEILKF 424
            .                      :...:|.|:.:..|       |:|...||  |:..|...:..
Yeast   389 I----------------------TVILKSFKLEQKEN-------NSLAFSLGSFYSNSSPLTISH 424

  Fly   425 KVQISKIYG------IALHQ----DILIQNTA---------NIDSCSTVFDHASYLRYSDTASGF 470
            |.: ..:.|      |||:.    ||:|.:..         .:..|.:.:.:.|.......||..
Yeast   425 KTK-PLLTGEQTPQSIALNMGDELDIIISHDGIAHFFKIFQFVSKCMSFYQNKSKGMMPQIASDT 488

  Fly   471 FLGTLLEN---HIPLQNQQYLL-LRAAPIIVSGSQQRY------FQELTSR-----TTLSATAVD 520
            .....|.:   .:.|:...:|| .:.:|.|...:::.|      |::|.||     |..|.|..:
Yeast   489 KRTVQLTSKAVKLSLKFPYFLLCFQVSPFIYDSNRELYIELVDVFKKLPSRCTKILTMSSITISN 553

  Fly   521 LIEVL------DNSKEHLLQFDRQRNCPDGYH-IRPEIVLTQSSSFMFKQNHNRCSNKIECSLDE 578
            |...|      |..||.|:.        ...| |..|::        |.:.::.....:|
Yeast   554 LQSPLQLGSYDDTLKEALIY--------SSVHAIIKEVI--------FNEEYSGIVQLVE----- 597

  Fly   579 CTAELDISIYDRLGALFGSSPFSGDSASSTPYPDDPNQTEFVVKSENLRLHLRFPVVDGRAANDP 643
                 |||.:.:|.....:|..:|.|.|        .:..|:.:|..:....||......:||..
Yeast   598 -----DISAFGKLFTDSKNSECTGKSKS--------KRGSFLQRSVRVLNSSRFVYKQSLSANFS 649

  Fly   644 LKIPWWKKNVRRDFLAVEFRSLVVSSRSQISIVSDELDVFYCDADKQSAVHLLKCQQKMQPNKKI 708
            |||...|..| .:.:..:|.|:.....:....::|:..:.|                 ...|.|:
Yeast   650 LKIDSMKLKV-SEIIGPQFGSVEALLSNNFFAITDDSQIVY-----------------FTKNLKV 696

  Fly   709 QIDVLQLKDTSDGQKKARKSPFSSKCTFGYTSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQS 773
            :                ||:|                        |||  |.:||
Yeast   697 E----------------RKTP------------------------SLL--EPQEI---------- 709

  Fly   774 SKLKIFAFIPHVKVVLESKSMYE---LIYNRLNGDL-FMWEPRSPHY----------DISPDNEV 824
                       :.||| :|::.|   .::.|.||.| .::.....||          :|.|||
Yeast   710 -----------MSVVL-NKAVNEPVLYVHRRANGKLKVIFNNIRIHYYARWLEILKKNIGPDN-- 760

  Fly   825 PESKDLYAEPQLEEFRRNLLLSTSAMESSIYFSMAEPTASAPPAPPVRNEAFSFELFVEQGTLIL 889
            ..|||   ||..::                 .|..:||:           .|.:||.....:|||
Yeast   761 ASSKD---EPVSQK-----------------LSKKQPTS-----------GFPWELKCLDCSLIL 794

  Fly   890 FSH--------LLDPETNQRSKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGN 946
            ...        :||..|...|....:.::..|...||.::...|      |.||
Yeast   795 HPFRLKSVMVIVLDNLTTGGSSFIPQAKLLSKANTLFLIDDYQN------FKIQ----------- 842

  Fly   947 TLQDLELAWSDLADEKLLPTIYNFASVHQQQDRKRMEVLSLVAEIKKQP-----EQRIKRMKMSF 1006
                         .:|..|::.||.:........:::.|:.:  |.|..     :.:|:::.:|
Yeast   843 -------------KDKNWPSLINFYAGQGFSAIGKIDTLNFL--INKSDGALLLDCKIEQVGLS- 891

  Fly  1007 GICGAILQHHSCHSEHSWLNQLIDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRA 1071
             :|....|        ::....||......||.||        :.:..:.|          |...
Yeast   892 -LCADSFQ--------TFCQLCIDLKYPQTFPDEE--------KFRTQLKN----------PIDV 929

  Fly  1072 FLDLGYCTLSSNIISSMSGCTLRLLAEDC-VLQLGLVKEESNDSLIPVLNL--GLLNISFRLN-- 1131
            |.|:                       || :.....::|.::.:....::|  ..|:.:...|
Yeast   930 FKDI-----------------------DCDLFNSAFIRENNHQNDYDSVHLVDSFLDKTHEFNNG 971

  Fly  1132 --AEGSGQPRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPN 1194
              ::.|.|...::.||           |..|...::....:..|...|:|    |||.|...|..
Yeast   972 ARSKLSSQGSYEMDSS-----------SGTATGGILLPHESYLDSAQPKE----EDTPPIASKEQ 1021

  Fly  1195 EEHEMSDHTQNHVSKLMADAVIDVESSPNLRAMKSPGGREEGIEIFYFPD-EPKEKRK---STSA 1255
            |..                  :|:..|.::          |.:.|..|.. :.|..||   :|..
Yeast  1022 ERD------------------VDIRGSIDV----------EKVVIKLFDGYDWKYTRKFIANTVE 1058

  Fly  1256 KLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLGNASLEERDFDI 1320
            ||..:....|:.|...::...|:| |..|.|..:.....|.|...:..|:..:.|:
Yeast  1059 KLDKELSKAEASSSKSNVPQSEAN-IFDSIYISANKNNVTDLRRNLDGEIQGVQNS--------- 1113

  Fly  1321 IHDEEISRMDKFGVKQIYISEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEMTFTWHL 1385
                 .|.:.|..::.....:..:|:...|..|.:.:|
Yeast  1114 -----FSDVSKVNLRPSKHYKALIQLNKVHVNLKNYRV--------------------------- 1146

  Fly  1386 YGGRDFPDEPLKKSSSSATSGFGMSDTYKYGVSQAQEQDKQDKKGSKKGLLKQPKGSQRNLEVLV 1450
                   |||.:.:|.::|                                          :||
Yeast  1147 -------DEPDESNSDNST------------------------------------------DVL- 1161

  Fly  1451 EMQLSKIRFSYETYPLTSMYSSRQVLLVSEIEIRDRLRSSDINKFLYHPTGNNLSHKP---DENM 1512
                                 :|.|:.:.|.||.|.:.:|..|||:     ..|.|:|   ...|
Yeast  1162 ---------------------NRCVVSIYEFEIIDNVPTSTWNKFV-----TLLKHEPWPHSSPM 1200

  Fly  1513 VIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRNSASAAGGTKTEGSS 1577
            .::....:|| .....|.|..:::::.|::|::|||||.||..|..  |::...
Yeast  1201 FLLDLEFIRP-IDFLQAVELVMQLNVAPLRLHVDQDTLEFLIRFLG--FKDKRF----------- 1251

  Fly  1578 SSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEE---NSLDVELEEDPATAPPVFFRE 1639
                            ||.|:.||.           |.|::   ||:.:.|:..|...
Yeast  1252 ----------------ELIDEYPDI-----------VFIQKFSTNSIKLRLDYKPKKV------- 1282

  Fly  1640 VIFSPALPICFDYHGRRIELSRGPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAKEW 1704
                       ||.|     .|...|..:|....|.||.|.|:.:| ..|:.|:::|...|...|
Yeast  1283 -----------DYAG-----LRSGQTSELMNFFTLDGSKIILKSVV-LYGLNGFDELNNKLKAIW 1330

  Fly  1705 LKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSFTART---- 1765
            ..||.:.|||.:|.|:.|..:.:.:..|:..|..:.:.:|.::|.:.|..:.|...|...|
Yeast  1331 TPDITKKQLPGVLEGLAPVRSFMAIGSGVKTLVTVLMSEYRQEGHLGRSLKKGGNVFLKTTTGDF 1395

  Fly  1766 ALAALEITSRIIHLLQFTAETTFDMLSAGPSMKKRK---------------------------GG 1803
            ....:::||....:|:.|.|....:.|.|......|                           |.
Yeast  1396 VKLGVKLTSGTQAILENTEELFGGVGSNGRVYDASKFGSADGADSDTAAVLDLDTLFEEDQLVGS 1460

  Fly  1804 RQGKRRRQ-------------------------GRPKDLREGVANAYTIVREGINESANTLIEAA 1843
            :..:.|..                         .:|.||..|:..||:.:.:.::.:.:.:..|.
Yeast  1461 KYSRIRDHEPTAVVIDMSSPGDHNEPTIVSLYADQPLDLPTGLKEAYSSLEKHMHIAYDAVWRAK 1525

  Fly  1844 ITEHDQK--GYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWK 1902
            ....|.|  |.|.|...|.|..|..::.|.:.||:|.:..|.|..:.:......:..||:|
Yeast  1526 GQMKDDKRGGPSAAAVYVARAAPVAIIRPLIGATEAVSKTLQGIANQVDKTHNEQINDKYK 1586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_647748.1	Chorein_N	13..117	CDD:463646	26/144 (18%)
		ATG2_CAD	<1116..1185	CDD:433120	12/74 (16%)
		ATG_C	1814..1902	CDD:462761	23/89 (26%)
ATG2	NP_014157.1	ATG2_CAD	784..921	CDD:433120	33/186 (18%)
		ATG_C	1489..1586	CDD:462761	23/96 (24%)