Protein Alignment Atg2 and Atg2b

DIOPT Version :10

• Sequence 1: NP_647748.1
• Gene: Atg2 / 38344
• FlyBaseID: FBgn0044452
• Length: 1906
• Species: Drosophila melanogaster
• Sequence 2: NP_001390444.1
• Gene: Atg2b / 76559
• MGIID: 1923809
• Length: 2076
• Species: Mus musculus
• Alignment Length: 2244
• Identity: 596/2244 - (26%)
• Similarity: 967/2244 - (43%)
• Gaps: 520/2244 - (23%)

  Fly     6 PW---DGLKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGWA 67
            ||   :.:|.:.||||||||||.|.:..|:||||.:|||.|...:..:.|.....|::.|.....
Mouse     2 PWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAP 66

  Fly    68 FEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESM-WSS-VSSSMQMA 130
            .||..|.|..:::.|||.:|:.::.:||:..|.:..||..|..:|:   |.| ||| ::||||:|
Mouse    67 LEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRVATGS---EPMYWSSFMTSSMQLA 128

  Fly   131 EECMKQVDDD------VPFLNHNNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKL 189
            :||:.|...|      .||       .|||||||||:.||.|::....:|.|.||
Mouse   129 KECLSQKLTDEQGEASQPF-------EGLEKFAETIETVLRRVKVTFIDTVLRIE---------- 176

  Fly   190 VLSFQASHVEYKNKTGYEMPMSTSQDTETEE--DPNSSFNA-LPMIAKHNLV-IEGLSL------ 244
                   ||...:|||..:.:...:....:|  |.:|..|. .|....|.|: :.|:||
Mouse   177 -------HVPENSKTGAALEIRVDRTVYCDETADESSGVNVHQPTAFAHKLLQLSGVSLFWDEFS 234

  Fly   245 ---HTSEVLDVMDHQFGP------------TPYEQLCK------------IVELKGAQNIQINIK 282
               .:|.|......:..|            .|:.||.:            |..|.|...:.:.:|
Mouse   235 ASAKSSPVCSTAPVETEPKLSPSWNPKIVYEPHPQLTRTLPEIAPSDPVQIGRLLGRLELSLTLK 299

  Fly   283 QTENIVGPKVSLELSLDDIYFMLTPRQIHLLIEFSKGF----NCG--GQQERPKKGRSLKSAPPS 341
            |.|.:.|.|:.::..:|..:..|:|||:|||::.....    |..  |...:.:|.|.::.....
Mouse   300 QNEVLPGAKLDVDGQIDSFHLFLSPRQVHLLLDMLAAIAGPENSSKIGLANKDRKNRPMQQEDEY 364

  Fly   342 EYQM----HSLQQPTRMTGILGQNADWCT---------------GMSEADPSEYSV-----YGNP 382
            ..||    :.|::.:...|:..:.:.:.|               .|::.|.| :|:     .|:|
Mouse   365 RIQMELNRYYLRKDSLSMGVSSEKSFYETETARTPSSREEEVFFSMADMDMS-HSLSSLPPLGDP 428

  Fly   383 PRSGYARSRKMSESTNSMVTSCTNT-LQQELGYTEKS---GEILKFKVQISKIYGIALHQDI--- 440
            |.         .:...|:.::.||| ....|..|...   ||....|.|  .:.|.|...|:
Mouse   429 PH---------MDLELSLTSTYTNTPAGSPLSATVLQPTWGEFADHKEQ--PVRGPAFQSDVVHP 482

  Fly   441 -------LIQNTANIDSCSTVFD-------------HASYLRYSDT----------ASGFFLGTL 475
                   |...:|::|.....|.             |...|..::|          |:.||  :.
Mouse   483 ASLQKAALSSRSASVDESRPEFICRLALGIFSVSVLHIDPLSPAETSLNVNPLTRMATDFF--SC 545

  Fly   476 LENHIP--LQNQQYLLLRAA----------PIIVSGSQQRYFQELTS-----RTTLSATAVDLIE 523
            :|...|  .....:...||.          ..|.:|.:..|.|...|     .|.:|...::.:|
Mouse   546 VEKMDPAIFSTGDFKSFRAVFAEACSHDHLRFIGTGIKVSYEQRQRSASRHFSTDMSVGQMEFLE 610

  Fly   524 VLDNSKEH--------LLQFDRQRNCPDGYHIRPEIVLTQSSSFMFKQNHNRCSN-----KIECS 575
            .|..:..|        ||.|..:........:..::....|.:...:.|..|.|:     :::..
Mouse   611 CLFPTDCHSVPSHYTELLTFHSKEGTDAHLPVCLQLHYKHSETRGPQGNQARLSSVPQKAELQIK 675

  Fly   576 LDECTAELDISIYDRLGALFG------------------SSPFSGDSASSTPYPDDPN-----QT 617
            |:....||||||.|||.:|..                  :...|...|.:..:.||.:     :.
Mouse   676 LNPVCCELDISIVDRLNSLLQPQKLTTVEMMASHMYASYNKHISLHKAFTEVFLDDSHSPANRRV 740

  Fly   618 EFVVKSENLRLHLRFPVVDGRAANDPLKIPWWKKNVRRDFLAVEFRSL---------VVSSRSQI 673
            ...|.:..|.|.:|||:.|.|  :|..:.||:||:::::.|.:||..|         ....::::
Mouse   741 SVQVATPALHLSVRFPIPDLR--SDQERGPWFKKSLQKETLHLEFTDLESKTEFVGGSTPEQTKL 803

  Fly   674 SIVSDELDVFY-----------------CDADKQSAVHLLKCQQKMQPNKKIQIDVLQ------- 714
            .:...||...:                 .|.|..|:......:..::.|......:|:
Mouse   804 ELTFRELSGSFQEEKGGPSVKFFHVSGGVDGDTASSDDFDWPRMVLKINPPAMHSILERIAAEEE 868

  Fly   715 -----------------LKDTSDGQKKARKSPFSSKCTFGYTSHVEGLDGSVDKTDSLLPGETEE 762
                             |||..|.::.| .|||||:...            .:....::||:..|
Mouse   869 EENDGHYQEEEDGGAHSLKDVCDLRRPA-PSPFSSRRVM------------FENEQMVMPGDPVE 920

  Fly   763 INEFCDSCTQSSKLKIFAFIPHVKVVLESKSMYELIYNRLNGDLFMWEPRSP---------HYDI 818
            :.||.|....:|...:...:|::.:.|.:|..||.:|||:..||.:|||.:|         .|.|
Mouse   921 MTEFQDKAISNSHYVLELLLPNIHLTLPNKGFYEKLYNRIFNDLLLWEPTAPSPVETLENVSYGI 985

  Fly   819 ------------SPDNEVPESKDLYAEPQLEEFRRNLLLSTSAMESSIYFSMAEPTASAPPAPPV 871
                        |.|:..|....::.:..          |.|..|:..|||..:|...:.....:
Mouse   986 GLSVASQLINTFSKDSFSPFKSAVHYDED----------SGSEEETLQYFSAVDPNYRSRRKKKL 1040

  Fly   872 -----RNEAF-SFELFVEQGTLILFSHLLDPETNQRSKECGKFQVNLKELRLFTVNGLDNDSTRS 930
                 .:::| |..|.:..|.:.:|:.:.....:....:.|:|.:.......|.|...:....:.
Mouse  1041 DSQNKNSQSFLSVLLSINHGLMAVFTDVKQENGDPMESKHGEFWLEFNSGSFFCVTKYEGFEDKH 1105

  Fly   931 FFSIQLGEIDALHCGNTLQDLELAWSDLADEKLL----------------PTIYNFASVHQQQD- 978
            :..:....:...|.|            :.|..:|                ||||:     .::|
Mouse  1106 YICLHSSSLRLYHKG------------IVDGAILPTETRLPCSTRPHWLEPTIYS-----SEEDG 1153

  Fly   979 ----------RKRMEVLSLVAEI-KKQPEQRIKRMKMSFGICGAILQHHSCHSEHSWLNQLIDFM 1032
                      ...:.:||:..:| ..:.|...|...::.|:.||.|||....:..||..|:::|:
Mouse  1154 LSRTASDGVGGDNLNMLSVAVKILSDKSESNTKEFLVAVGLKGATLQHRVLPAGLSWHEQILNFL 1218

  Fly  1033 DVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLGYCTLSSNIISSMSGCTLRLLA 1097
            ::||.|:..|.|....:...:|:|:..:||||...|.|:.|.:...::||::....|..|||::.
Mouse  1219 NIADEPVLGYNPPTSFTTFHVHLWSCALDYRPLHLPLRSLLTVETFSISSSVALDKSSSTLRIIM 1283

  Fly  1098 EDCVLQL----GLVKEESNDSLIPVLNLGLLNISF-RLNAEGSGQ---PRVDLRSSIHDMHLKTC 1154
            ::..|.|    ..|....|...:.|:::|||.::. .:.::..|:   ||.:|..|...:|::||
Mouse  1284 DEAALHLSDKCNTVTVNLNRDYVRVMDMGLLELTITAVKSDSDGEQTAPRFELHCSSDVVHIRTC 1348

  Fly  1155 YDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNEEHEMSDH-------TQNHVSKLMA 1212
            .||.|||..||.|||:..||..|.:..:.......:||.:.....|.|       .|..:..||:
Mouse  1349 SDSCAALMNLIQYVASYGDLHGPHKAEMKPGVPQRKPKVDSSARSSSHGPVLPEADQQILRDLMS 1413

  Fly  1213 DAVIDVESSPNLRAMKSP-GGREEGI-------------EIFYFPDEPKEKRKSTSAKLQTKSLM 1263
            ||:.:::    |:...:| |.:..|:             ::|.||||.....:.:|....:.:..
Mouse  1414 DAMEEID----LQQASAPVGPQANGVLDEKSHTQEPCCSDLFLFPDESGNVSQESSPAYPSLTHH 1474

  Fly  1264 VESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLGNASLEERDFDIIHDEEISR 1328
            :.|.:|.|...:.:...||        ..|:|                        ::.::|...
Mouse  1475 LISDAVTGVTAENDDFCIL--------FAPKT------------------------VVQEKEEEP 1507

  Fly  1329 MDKFGVKQIYISEDPLQIVDNHFELPHEKVDLLRPPSNFPVAESTYTLCEMTFTWHLYGGRDF-- 1391
            :.|..|      :|.:.|.|::|.||..:.|..:.|.:||:....|.:.|::..||||||:||
Mouse  1508 VIKIMV------DDAIVIKDDYFSLPITRTDSSKAPLHFPIPAVRYVVKEVSLVWHLYGGKDFAT 1566

  Fly  1392 --PDEPLKK-----SSSSATSGFGMSDTYKYGVSQAQEQDKQDKKGSKKGLLKQPKGSQRNLEVL 1449
              |..|.|.     ||.|.|.                         ::.|......|..||.:.|
Mouse  1567 APPTSPAKSYISPHSSPSQTP-------------------------TRHGRHTVCGGKGRNHDFL 1606

  Fly  1450 VEMQLSKIRFSYETYP---------LTSMYSSRQVLLVSEIEIRDRLRSSDINKFLYHPTGNNLS 1505
            :|:||||::|.:|.||         |.....||||.:|.::||||||.:|.:|||||.....::.
Mouse  1607 MEIQLSKVKFQHEVYPPCKPECESSLLEHPVSRQVFIVQDLEIRDRLATSQMNKFLYLYCSKDMP 1671

  Fly  1506 HKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNIDQDTLLFLEDFFSGMFRNSASAAGG 1570
            .|...||:.:|||:|||...: |.:||.||||::|::||||||.|.||:|||
Mouse  1672 RKAHSNMLTIKALHVRPESGR-SPQECCLRVSLMPLRLNIDQDALFFLKDFF------------- 1722

  Fly  1571 TKTEGSSSSATDMPVMSVSKMPEELSDKLPDSEVKEMVERNLNVLIEENSL-------------- 1621
                  :|.:|::.::..   |:....|.|.::|...:.|:|:...|.|.:
Mouse  1723 ------TSLSTEVELLLT---PDPEVTKSPGADVTCSLPRHLSTSKEPNLVVSFPGPKQASPNHR 1778

  Fly  1622 ------------DVELEEDPATAPPVFFREVIFSPALPICFDYHGRRIELSRGPVTGLIMGLAQL 1674
                        ||..||...:..||||||..|:..:||..||||:.:.:.:|.:.|:::|||||
Mouse  1779 ANSAEGGNGLEEDVSAEETSFSDQPVFFREFRFTAEVPIRLDYHGKHVSMDQGTLAGILIGLAQL 1843

  Fly  1675 QGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSGIGPTNAVLQLFQGIYDLFRL 1739
            ..|.:.|:.:..|.|:||.:||..:...|||.|||:||||.||.|:||.::::||.||:.||..|
Mouse  1844 NCSELKLKRLFYRHGLLGIDKLFSYAISEWLSDIKKNQLPGILGGVGPMHSLVQLVQGLKDLVWL 1908

  Fly  1740 PIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTAETTFDMLSAGP-SMKKRKGG 1803
            |||||.|||||:||||.||.||...||:||||:|:|::..:|..|||.:||:|... |::.:|..
Mouse  1909 PIEQYRKDGRIVRGFQRGAASFGTSTAMAALELTNRMVQTIQAAAETAYDMVSPSTLSIEPKKAK 1973

  Fly  1804 RQGKRRRQGRPKDLREGVANAYTIVREGINESANTLIEAAITEHDQKGYSGAVGAVVRQIPQLVV 1868
            |....|...:|.|||||||.||::|:|||.::|.|:.|.|..||:.:|.:||||.|:||||..||
Mouse  1974 RFPHHRLAHQPVDLREGVAKAYSVVKEGITDTAQTIYETAAREHESRGVTGAVGEVLRQIPPAVV 2038

  Fly  1869 CPAVLATQATTNILGGAKSSLIPEAKLEARDKWK 1902
            .|.::||:||:|:|||.::.:.|:.:.:...||:
Mouse  2039 RPLIVATEATSNVLGGMRNQIRPDVRQDESQKWR 2072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg2	NP_647748.1	Chorein_N	13..117	CDD:463646	38/103 (37%)
		ATG2_CAD	<1116..1185	CDD:433120	25/72 (35%)
		ATG_C	1814..1902	CDD:462761	43/87 (49%)
Atg2b	NP_001390444.1	Chorein_N	11..>105	CDD:463646	35/93 (38%)
		MRS6	17..>234	CDD:227376	82/243 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1373..1403		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1760..1793		3/32 (9%)
		ATG_C	1978..2072	CDD:462761	44/93 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2056..2076		3/17 (18%)