DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ProRS-m and Pars2

DIOPT Version :9

Sequence 1:	NP_647737.1	Gene:	ProRS-m / 38331	FlyBaseID:	FBgn0027082	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001014086.2	Gene:	Pars2 / 313429	RGDID:	1305345	Length:	480	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	188/440 - (42%)
Similarity:	276/440 - (62%)	Gaps:	21/440 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KASRIFCPALITPKNAVVKQTEQLS----------RSQKLLTELGLVKSGSNGTYQIMPMAQRSV 57
            :..|:....:..|:|  :::.:.||          :||:|:.::||:...|.|.|.:||...|:|
  Rat    41 RGQRLVVSRMFQPQN--LREDQVLSLEGRASDLTCKSQRLMLQVGLILPASPGCYHLMPYTVRAV 103

  Fly    58 DKCIDLVQSNMQQAGGQKITLPILTPTGLWKKTGRLDGDISEFYMVRDRSGKQFLMSPTHEEAVT 122
            :|.:.::...||..|||||.:|.|:|..||:.|||.|....|...::||.||::.:.||||||||
  Rat   104 EKLVRVIDQEMQAIGGQKINMPSLSPAELWRATGRWDLMGRELLRLKDRHGKEYCLGPTHEEAVT 168

  Fly   123 AMLATTSPISYRQLPLRLFQIGPKFRDELKTRFGLMRAKEFLMKDMYSFDVSEETAMETYTLVNA 187
            |::|:...:||:||||.|:|:..|||||.:.||||:|.:||.|||||:||.|.|.|.|||:||..
  Rat   169 ALVASQKKLSYKQLPLLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSSEAAQETYSLVCD 233

  Fly   188 AYDRLFKQLEVPFVKVNAATGIMGGSVSHEYHYVSPVGEDNLLQCSSCGFAGNSEVVK-APASCP 251
            ||.|||.:|.:.::|..|..|.:||::|||:.....:|||.|:.|.||.|:.|:|:|. :...||
  Rat   234 AYCRLFDRLGLRWMKARADVGSIGGTMSHEFQLPVDIGEDRLVVCPSCHFSANTEIVDLSQKICP 298

  Fly   252 SCNSSDLKEVRGVEVAHTFLLGDKYSKPLGATFLNTTGKPQSLVMGCYGIGITRVIAAALEVLSS 316
            .| ...|.|.:|:||.|||.||.|||....|.|.|..|:.....|||||:|:||::|||:||||:
  Rat   299 DC-QGPLTETKGIEVGHTFYLGTKYSSIFNAHFTNAHGESLLAEMGCYGLGVTRILAAAIEVLST 362

  Fly   317 DHELRWPKLLAPYDVCLIGPKQGSKEQPEAEVIE---NELLLNVGEICGHQELLHDDRKELTIGK 378
            :..:|||.|||||.||:|.||:||||....|::|   :::...:.::.|  |:|.|||..||||.
  Rat   363 EDCIRWPSLLAPYQVCIIPPKKGSKEAAATEIVERLYDDVTEALPQLRG--EVLLDDRTHLTIGN 425

  Fly   379 RLLEAKRLGHPLTIVVGAKSARLDSPKLEVHT-SKGETYELDFSETLKLV 427
            ||.:|.:||:|. :::.:|.|..|....||.: :.||...|.....::|:
  Rat   426 RLKDANKLGYPF-VIIASKRALEDPAHFEVWSQNTGEVVFLTKEGVMELL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ProRS-m	NP_647737.1	PRK09194	3..422	CDD:236405	187/433 (43%)
		ProRS_core_prok	24..313	CDD:238402	137/299 (46%)
		ProRS_anticodon_short	328..428	CDD:238438	38/104 (37%)
Pars2	NP_001014086.2	ProRS_core_prok	70..359	CDD:238402	135/289 (47%)
Pars2	NP_001014086.2	ProRS_anticodon_short	374..475	CDD:238438	38/104 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343901
Domainoid	1	1.000	218	1.000	Domainoid score	I2588
eggNOG	1	0.900	-	-		E1_COG0442
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5830
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2214
OMA	1	1.010	-	-		QHG52122
OrthoDB	1	1.010	-	-		D307110at33208
OrthoFinder	1	1.000	-	-		FOG0004664
OrthoInspector	1	1.000	-	-		oto97302
orthoMCL	1	0.900	-	-		OOG6_103003
Panther	1	1.100	-	-	LDO	PTHR42753
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3277
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810