DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pxn and TPO

DIOPT Version :10

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:XP_054199614.1 Gene:TPO / 7173 HGNCID:12015 Length:968 Species:Homo sapiens


Alignment Length:810 Identity:305/810 - (37%)
Similarity:452/810 - (55%) Gaps:74/810 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   652 PGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTGEARQLARAAEIYE 716
            |.:..|.....|:.:.:|.|:..|:......|...:|   .:||...:.|...:..:||||||.|
Human    46 PEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSP---AQLLSFSKLPEPTSGVIARAAEIME 107

  Fly   717 RTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSID 781
            .::..:::.|    ||..:..::. .|.||.:.|.::|.:|||:.:...|.|.:.|..::||.|.
Human   108 TSIQAMKRKV----NLKTQQSQHP-TDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPIT 167

  Fly   782 GTCNN---------------------------LQHPTWGASLTAFRRLAPPIYENGFSMPVGWTK 819
            |.|||                           :.||.||||.||..|..||:||:|||.|.||..
Human   168 GACNNRAGMGASLLSTGQCFQVAAPICIPRSKVDHPRWGASNTALARWLPPVYEDGFSQPRGWNP 232

  Fly   820 GMLYSGHAKPSARLVSTSL--VATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGID 881
            |.||:|...|..|.|:..:  |:.:.:|.|.|.:.::|.|||::|||:.....|.|..:: .|.|
Human   233 GFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGSD 297

  Fly   882 CKKSCEMAPPCYPIEVPPNDPRVRNRRCIDVVRSSAICGSGMTSLFF---DSVQHREQINQLTSY 943
            |:.:||...||:||::|..........|:...||||.||:|.....|   .:...|:|:|.|||:
Human   298 CQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSF 362

  Fly   944 IDASQVYGYSTAFAQELRNLTSQEGLLRVGVHFPRQKD----MLPF--------AAPQDGMDCRR 996
            :|||.|||.|.|..::|||.||.||||||   ..|.:|    .|||        .||:.|:.   
Human   363 LDASTVYGSSPALERQLRNWTSAEGLLRV---HARLRDSGRAYLPFVPPRAPAACAPEPGIP--- 421

  Fly   997 NLDENTMSCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQM 1061
              .|....||::||.|.:|...|.|:||:|:|||||:|:.||.:|:||..|.:||||||:|||..
Human   422 --GETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALH 484

  Fly  1062 QHITFKQWLPLIIG-ESGMEMMGEYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQP 1125
            |.||.:.::|.|:| |:..:.:|.|:||:...||:::|.|:|||.||||..|:|::.||:.:||.
Human   485 QIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE 549

  Fly  1126 IPQ-GHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDL 1189
            .|. ..|.||:|||:||.|...||:|||:||.||.||||:..||.:|.||||:||..:::..|||
Human   550 HPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDL 614

  Fly  1190 AAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGIL 1254
            |:||:|||||||:||||.:|:.|.|...:...||:..|:|..:..|:.:||.||||:||||||:.
Human   615 ASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLA 679

  Fly  1255 EDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQV 1319
            |:.:...:.||||.||:.:|.:.|||||..::||..||:..|..::::.:..||:|| .....:|
Human   680 ENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICD-NTGLTRV 743

  Fly  1320 TENVFILAKHQGGYKKCEDIIGINLYLWQEC----GRCNSPPAIFD-SYIPQTYTKR-----SNR 1374
            ..:.|.:.|....::.|:.|.|:||..|:|.    .:|..|.::.: .::....:.|     |.|
Human   744 PMDAFQVGKFPEDFESCDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCR 808

  Fly  1375 QKRDLGKENDEVATAESYDSPLESLYDVNE 1404
            ...:|........|.|.:|.......||||
Human   809 HGYELQGREQLTCTQEGWDFQPPLCKDVNE 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 leucine-rich repeat 54..77 CDD:275380
LRR <55..>184 CDD:443914
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
leucine-rich repeat 126..149 CDD:275380
leucine-rich repeat 150..173 CDD:275380
Ig_3 235..311 CDD:464046
Ig 366..450 CDD:472250
Ig strand B 384..388 CDD:409544
Ig strand C 397..401 CDD:409544
Ig strand E 420..424 CDD:409544
Ig strand F 434..439 CDD:409544
Ig strand G 447..450 CDD:409544
Ig_3 458..533 CDD:464046
Ig 553..644 CDD:472250
Ig strand B 570..574 CDD:409353
Ig strand C 584..588 CDD:409353
Ig strand E 610..614 CDD:409353
Ig strand F 624..629 CDD:409353
Ig strand G 638..641 CDD:409353
peroxidasin_like 898..1338 CDD:188658 199/456 (44%)
VWC 1465..1523 CDD:278520
TPOXP_054199614.1 thyroid_peroxidase 206..773 CDD:188657 249/575 (43%)
CCP 781..834 CDD:153056 9/52 (17%)
EGF_CA 835..878 CDD:214542 4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

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