Protein Alignment Pxn and PTGS2

DIOPT Version :10

• Sequence 1: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Sequence 2: NP_000954.1
• Gene: PTGS2 / 5743
• HGNCID: 9605
• Length: 604
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 139/656 - (21%)
• Similarity: 219/656 - (33%)
• Gaps: 224/656 - (34%)

  Fly   744 LLSREHLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYE 808
            :|:|. |.|.|.|:  :.|...|.|:..|.:.      |.|.::....:....|     ....|.
Human     1 MLARA-LLLCAVLA--LSHTANPCCSHPCQNR------GVCMSVGFDQYKCDCT-----RTGFYG 51

  Fly   809 NGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATKEITPDARITHMVMQWG-----QFLDHDL--- 865
            ...|.|...|:..|:   .||:...|...|            ||....|.     .||.:.:
Human    52 ENCSTPEFLTRIKLF---LKPTPNTVHYIL------------THFKGFWNVVNNIPFLRNAIMSY 101

  Fly   866 -----DHAIPSVSS-------ESWDGIDCKKSCEMAPPCYPIEVP-----------PNDPRVRNR 907
                 .|.|.|..:       :||:..........|.|..|.:.|           |:...:..:
Human   102 VLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEK 166

  Fly   908 RCIDVVRSSAI---CGSGMTSLFFDSVQHREQ-------------INQLTSYIDASQVYGYSTAF 956
            .   ::|...|   .||.|...||  .||...             .|.|...:|.:.:||.:.|.
Human   167 L---LLRRKFIPDPQGSNMMFAFF--AQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLAR 226

  Fly   957 AQELRNLTSQEGLLRVG------------------VHFPRQKDMLPFAAPQDGMDCRRNLDENTM 1003
            .::||  ..::|.::..                  ::.|:..:.|.||..|:
Human   227 QRKLR--LFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQE------------- 276

  Fly  1004 SCFVSGDIRVNEQVGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQ 1068
               |.|.:     .||:...|||:|||||:...|||.:..|..:.|:|.:|.|
Human   277 ---VFGLV-----PGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLI------------ 321

  Fly  1069 WLPLIIGESGMEMMGEY----QGY------NPQL--------NPSIANEFATAALRFGHTIINPI 1115
                :|||:...::.:|    .||      :|:|        ...||.||.|  |...|.:
Human   322 ----LIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNT--LYHWHPL---- 376

  Fly  1116 LHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQ 1180
               |.:|||...|.:  .::.|.....:..|.|:...:..|....|......:|: ....:|:.|
Human   377 ---LPDTFQIHDQKY--NYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNV-PPAVQKVSQ 435

  Fly  1181 TAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDN 1245
            .           :|.:.|......:|.|||...|...:.||:|.||   .|:..:::.|||..|.
Human   436 A-----------SIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGE---KEMSAELEALYGDIDA 486

  Fly  1246 VDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENPGVFSPEQLTQIKQANFGRVLC 1310
            |:                  |:..||||:.|                 |:       |.||..:.
Human   487 VE------------------LYPALLVEKPR-----------------PD-------AIFGETMV 509

  Fly  1311 DVGDNF 1316
            :||..|
Human   510 EVGAPF 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380
		LRR	<55..>184	CDD:443914
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		Ig_3	235..311	CDD:464046
		Ig	366..450	CDD:472250
		Ig strand B	384..388	CDD:409544
		Ig strand C	397..401	CDD:409544
		Ig strand E	420..424	CDD:409544
		Ig strand F	434..439	CDD:409544
		Ig strand G	447..450	CDD:409544
		Ig_3	458..533	CDD:464046
		Ig	553..644	CDD:472250
		Ig strand B	570..574	CDD:409353
		Ig strand C	584..588	CDD:409353
		Ig strand E	610..614	CDD:409353
		Ig strand F	624..629	CDD:409353
		Ig strand G	638..641	CDD:409353
		peroxidasin_like	898..1338	CDD:188658	104/482 (22%)
		VWC	1465..1523	CDD:278520
PTGS2	NP_000954.1	EGF_CA	19..54	CDD:238011	7/45 (16%)
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	118/565 (21%)