Protein Alignment Pxn and duox

DIOPT Version :10

• Sequence 1: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Sequence 2: XP_073799394.1
• Gene: duox / 565097
• ZFINID: ZDB-GENE-091117-14
• Length: 1537
• Species: Danio rerio
• Alignment Length: 744
• Identity: 188/744 - (25%)
• Similarity: 313/744 - (42%)
• Gaps: 118/744 - (15%)

  Fly   776 RYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAK---PSARLVSTS 837
            ||   ||..|||.....||:..:..||.|..|.:|           :|....:   |:.|.:||
Zfish    33 RY---DGWYNNLADHDRGAADASLVRLYPAQYMDG-----------VYLARQEPHLPNPRRIST- 82

  Fly   838 LVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSES-----WDGIDCKKSCEMAPPCYPIEV 897
                         |.|..|.|.     |.|...||.|.:     |..|...:.....|....|:|
Zfish    83 -------------TAMSGQSGL-----LSHKNRSVLSVAFGYHVWSEISESRRAGCPPEFMHIKV 129

  Fly   898 PPNDPRVRNRRCIDVVRSSAIC------GSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAF 956
            ..:||       :.|..||...      ....||........|.|:|.:|::||.|.:||.|:::
Zfish   130 QKDDP-------VFVSNSSQPVLLQFQRADWDTSTGKSPNNPRTQVNHVTAWIDGSSIYGSSSSW 187

  Fly   957 AQELRNLTSQEGLLRVGVHFPRQKD--MLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGL 1019
            :..||..:............||:..  .|.:::|    |.....|..:...:..|:...||.:..
Zfish   188 SDALREFSGGRLSSSSSRDMPRRSSNGYLMWSSP----DPSSGPDSGSQELYEFGNAWANENIFS 248

  Fly  1020 LAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGE 1084
            :....||.|.||.:||||.:.:..|..:.|:|.|||.|.|..|:|.|.:|||..:|..    :..
Zfish   249 VTEGIIWFRYHNYLASKLHKEHPSWSDEELFQHARKRVIATFQNIAFYEWLPAFLGTH----VTS 309

  Fly  1085 YQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNET--FQPIPQGH------LLLHKAFFAPW 1141
            |.||...::|.|:.||..||:|||.|:..|.:::.|.|  ::.:....      |.|...|   |
Zfish   310 YPGYQKYVDPGISVEFEAAAVRFGLTLAPPGVYKRNRTCHYRSVVNDDASKSPGLRLCNTF---W 371

  Fly  1142 -----RLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHG 1201
                 .|.....||.|:.|..:..|:.:  |..:..:|.:.::........|..|:.||||||.|
Zfish   372 NRNNPHLQSSLDVDELIMGMASQIAERE--DNIIVEDLRDYMYGPLRFSRSDAVALTIQRGRDFG 434

  Fly  1202 MPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHP-DNVDVWLGGILEDQVEGGKVGP 1265
            :|.||..|:..::.....|||:..::...::.:::.:||.:. ..:::::||:||.| ||  .||
Zfish   435 LPSYNQIREALSMAPVNSFEDINPKLKDTKLLKELADLYENDISRLELFVGGLLETQ-EG--PGP 496

  Fly  1266 LFQCLLVEQFRRLRDGDRLYYENP--GVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAK 1328
            :|..::::||.|:|:.||.::||.  |:|:.|::..|:...|..||.||             .:.
Zfish   497 VFSTIILDQFERIRNADRFWFENKQNGLFTEEEIKAIRNTTFHDVLLDV-------------TSA 548

  Fly  1329 HQGGYKKCEDIIGINLYLWQECGRCNSPPAIFDSYIPQTYTKR-SNRQKRDLGKENDEVATAESY 1392
            .:|..::       :::.|:....|..|..|..|.: |..||. |.....|..|....|.....:
Zfish   549 EKGDIQR-------SVFFWKNGDPCPQPQPIRASDL-QPCTKAFSMSYFDDSSKVGFGVTVVVLF 605

  Fly  1393 DSPLESLYDVNEERVSGLEEL-IGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQL 1456
            ..|:.|...|:....|.:.:: ...|::..:|.....:..|.:..:..||.:..    ..||.|:
Zfish   606 LFPVVSSLTVSYIVASAVAQVRTARFKRFQQKRSGSTKHKEPAHGTTASEWLGH----NTAPRQV 666

  Fly  1457 V---SKPKRSHCVDDKGTTRLNNEVWSPD 1482
            .   |:.|.....|:.|:...::.:.:.|
Zfish   667 TLAFSEKKVFQTFDENGSPLSSHSLGNQD 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380
		LRR	<55..>184	CDD:443914
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		Ig_3	235..311	CDD:464046
		Ig	366..450	CDD:472250
		Ig strand B	384..388	CDD:409544
		Ig strand C	397..401	CDD:409544
		Ig strand E	420..424	CDD:409544
		Ig strand F	434..439	CDD:409544
		Ig strand G	447..450	CDD:409544
		Ig_3	458..533	CDD:464046
		Ig	553..644	CDD:472250
		Ig strand B	570..574	CDD:409353
		Ig strand C	584..588	CDD:409353
		Ig strand E	610..614	CDD:409353
		Ig strand F	624..629	CDD:409353
		Ig strand G	638..641	CDD:409353
		peroxidasin_like	898..1338	CDD:188658	126/463 (27%)
		VWC	1465..1523	CDD:278520	3/18 (17%)
duox	XP_073799394.1	None