DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pxn and DUOX2

DIOPT Version :10

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_054799.4 Gene:DUOX2 / 50506 HGNCID:13273 Length:1548 Species:Homo sapiens


Alignment Length:743 Identity:185/743 - (24%)
Similarity:290/743 - (39%) Gaps:201/743 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   776 RYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAK---PSARLVSTS 837
            ||   ||..|||:|...||.....:|..|..|.:|           :|....:   |:.|.:|.:
Human    37 RY---DGWFNNLRHHERGAVGCRLQRRVPANYADG-----------VYQALEEPQLPNPRRLSNA 87

  Fly   838 LVATKEIT--PDARITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPC----YPIE 896
              ||:.|.  |.   .|.....|.|..:   |.:..|.|..            .|.|    ..|.
Human    88 --ATRGIAGLPS---LHNRTVLGVFFGY---HVLSDVVSVE------------TPGCPAEFLNIR 132

  Fly   897 VPPNDPRVRNRRCIDVV----RSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFA 957
            :||.||.....:..|||    ||.....:|.:     ....|:..||:|.::|.|.:||.|.:::
Human   133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRS-----PSNPRDLANQVTGWLDGSAIYGSSHSWS 192

  Fly   958 QELRNLTSQEGLLRVGVH--FPR--QKDMLPFAAPQ--DGMDCRRNLDENTMSCFVSGDIRVNEQ 1016
            ..||:.:.  |.|..|..  |||  |..:|.:|||.  .|.:..|.|       :..|..|.|.:
Human   193 DALRSFSG--GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGL-------YAFGAERGNRE 248

  Fly  1017 VGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEM 1081
            ..|.|:..:|.|.||..|.:|.:.:..|:.:.|:|.|||.|.|..|:|...:|||..:    .:.
Human   249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKT 309

  Fly  1082 MGEYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNET--FQPIPQGHLLLHKAFFAPWRLA 1144
            :.||.||.|.|:|||:.||..|:.:|..|::.|.::..|.:  |:.:                  
Human   310 LPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKV------------------ 356

  Fly  1145 YEGGVDPLMRGFLAVPAK--------LKTPDQNLNTELTEKLFQTAHAVA--------------- 1186
                   |.:||.:..|.        .:.|:.|...|:.|.|...|..::               
Human   357 -------LNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYW 414

  Fly  1187 --------LDLAAINIQRGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHP 1243
                    .|..|.:||||||.|:|.|:.......|.:.:::.||...: ..::.:....||...
Human   415 PGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNV-DPQVLEATAALYNQD 478

  Fly  1244 -DNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDGDRLYYENP--GVFSPEQLTQIKQANF 1305
             ..:::.|||:||..   |..||||..::::||.|||||||.::||.  |:||.:::..|:....
Human   479 LSQLELLLGGLLESH---GDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTL 540

  Fly  1306 GRVLCDVGDNFDQVTENVFILAKHQGGYKKCEDIIGINLYLWQECGRCNSPPAIFDSYIPQTYTK 1370
            ..||..| .|.|                   ...:..|:::|.:...|..|..:....:||.   
Human   541 RDVLVAV-INID-------------------PSALQPNVFVWHKGAPCPQPKQLTTDGLPQC--- 582

  Fly  1371 RSNRQKRDLGKENDEVATAESYDSPLESLYDVNEERVSG-----------------LEELIGSFQ 1418
                                   :|| ::.|..|....|                 |..::..|:
Human   583 -----------------------APL-TVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFR 623

  Fly  1419 -KELKKLHKKLRKLEDSCNSADSEPVAQ 1445
             :|.|||.|||::......:.|..|..:
Human   624 GREHKKLQKKLKESVKKEAAKDGVPAME 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 leucine-rich repeat 54..77 CDD:275380
LRR <55..>184 CDD:443914
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
leucine-rich repeat 126..149 CDD:275380
leucine-rich repeat 150..173 CDD:275380
Ig_3 235..311 CDD:464046
Ig 366..450 CDD:472250
Ig strand B 384..388 CDD:409544
Ig strand C 397..401 CDD:409544
Ig strand E 420..424 CDD:409544
Ig strand F 434..439 CDD:409544
Ig strand G 447..450 CDD:409544
Ig_3 458..533 CDD:464046
Ig 553..644 CDD:472250
Ig strand B 570..574 CDD:409353
Ig strand C 584..588 CDD:409353
Ig strand E 610..614 CDD:409353
Ig strand F 624..629 CDD:409353
Ig strand G 638..641 CDD:409353
peroxidasin_like 898..1338 CDD:188658 132/485 (27%)
VWC 1465..1523 CDD:278520
DUOX2NP_054799.4 dual_peroxidase_like 38..594 CDD:188652 172/683 (25%)
EFh 824..885 CDD:238008
EFh 861..919 CDD:238008
COG4097 1037..1548 CDD:443273
NOX_Duox_like_FAD_NADP 1274..1548 CDD:99783
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.