Protein Alignment Pxn and Amigo1

DIOPT Version :10

• Sequence 1: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Sequence 2: NP_666249.2
• Gene: Amigo1 / 229715
• MGIID: 2653612
• Length: 492
• Species: Mus musculus
• Alignment Length: 351
• Identity: 95/351 - (27%)
• Similarity: 156/351 - (44%)
• Gaps: 59/351 - (16%)

  Fly     6 LMLQLLGLLLLL----AGGVQSVYCPAGCTCLERTVRCIRAKLSAVPK-LPQDTQTLDLRFNHIE 65
            |.|.||.:.|||    ..|...|.|||.|.|....:.|.:.:|..||: ||..|..|||..|::.
Mouse    10 LWLLLLSVFLLLFEVARAGRSVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLS 74

  Fly    66 ELPAN-AFSGLAQLTTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPRLEAI 129
            .|.|. ..:.|..|.:|.|:.|.|.::...|...:..||::.|::|.|..|...:|..:..||.:
Mouse    75 RLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVL 139

  Fly   130 FLENNDIWQLPAGLFDNLPRLNRLIMYNNKLTQLPV----DGFNRL----------NNLKR---- 176
            .|.||.|..:....|:::.:|.:|.:..|::::.||    || |:|          |.||:
Mouse   140 LLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDG-NKLPKLMLLDLSSNKLKKLPLT 203

  Fly   177 ------------LRLDGNAIDCNCGVYSLWRRWHLDVQRQLVSI-----SLTCAAPQMLQNQGFS 224
                        |.|..|.::|:|.:|.|:..|.   .|||.|:     .|.|...:.|.|  ..
Mouse   204 DLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQ---YRQLSSVMDFQEDLYCMHSKKLHN--IF 263

  Fly   225 SLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSCEV--TGLPRPQITWMHNTQELGLEEQAQAEI- 286
            ||  ..|.|:  ::..:..:|.:  |:.:.:.|:.  .|:.:   .|:..:.|..|.:.:...:
Mouse   264 SL--DFFNCS--EYKESAWEAHL--GDTLTIRCDTKQQGMTK---VWVSPSNEQVLSQGSNGSVS 319

  Fly   287 LPSGSLLIRSADTSDMGIYQCIARNE 312
            :.:|.|..:.....|.|:|.|.|..|
Mouse   320 VRNGDLFFKKVQVEDGGVYTCYAMGE 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380	8/23 (35%)
		LRR	<55..>184	CDD:443914	42/159 (26%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		leucine-rich repeat	150..173	CDD:275380	9/36 (25%)
		Ig_3	235..311	CDD:464046	14/78 (18%)
		Ig	366..450	CDD:472250
		Ig strand B	384..388	CDD:409544
		Ig strand C	397..401	CDD:409544
		Ig strand E	420..424	CDD:409544
		Ig strand F	434..439	CDD:409544
		Ig strand G	447..450	CDD:409544
		Ig_3	458..533	CDD:464046
		Ig	553..644	CDD:472250
		Ig strand B	570..574	CDD:409353
		Ig strand C	584..588	CDD:409353
		Ig strand E	610..614	CDD:409353
		Ig strand F	624..629	CDD:409353
		Ig strand G	638..641	CDD:409353
		peroxidasin_like	898..1338	CDD:188658
		VWC	1465..1523	CDD:278520
Amigo1	NP_666249.2	leucine-rich repeat	44..64	CDD:275380	6/19 (32%)
		LRR 1. /evidence=ECO:0000269|PubMed:21983541	62..83		7/20 (35%)
		leucine-rich repeat	65..87	CDD:275380	7/21 (33%)
		LRR	<66..>224	CDD:443914	42/158 (27%)
		LRR 2. /evidence=ECO:0000269|PubMed:21983541	87..108		6/20 (30%)
		leucine-rich repeat	88..111	CDD:275380	6/22 (27%)
		LRR 3. /evidence=ECO:0000269|PubMed:21983541	111..132		7/20 (35%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		LRR 4. /evidence=ECO:0000269|PubMed:21983541	135..156		7/20 (35%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR 5. /evidence=ECO:0000269|PubMed:21983541	159..180		5/20 (25%)
		leucine-rich repeat	160..186	CDD:275380	9/26 (35%)
		LRR 6. /evidence=ECO:0000269|PubMed:21983541	186..206		3/19 (16%)
		leucine-rich repeat	187..210	CDD:275380	3/22 (14%)
		IG_like	279..357	CDD:214653	15/72 (21%)
		Ig strand E	323..327	CDD:409512	2/3 (67%)
		Ig strand F	337..342	CDD:409512	2/4 (50%)
		Ig strand G	351..354	CDD:409512
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..492