Protein Alignment Pxn and duox-2

DIOPT Version :10

• Sequence 1: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Sequence 2: NP_490684.1
• Gene: duox-2 / 186188
• WormBaseID: WBGene00018771
• Length: 1503
• Species: Caenorhabditis elegans
• Alignment Length: 684
• Identity: 188/684 - (27%)
• Similarity: 316/684 - (46%)
• Gaps: 125/684 - (18%)

  Fly   776 RYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYS-GHAKPSARLVSTSLV 839
            ||   ||..|||.:..||::.:...|.|...|.:|           :|| .::.||||.:|..|.
 Worm    40 RY---DGWYNNLANSEWGSAGSRLHRDARSYYSDG-----------VYSVNNSLPSARELSDILF 90

  Fly   840 ATKEITPDAR-ITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVPPNDPR 903
            ..:...|:.| .|.::..:.|.:.:::..:         :|:.|...      ...|:||..| .
 Worm    91 KGESGIPNTRGCTTLLAFFSQVVAYEIMQS---------NGVSCPLE------TLKIQVPLCD-N 139

  Fly   904 VRNRRC-----IDVVRS--SAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELR 961
            |.:..|     |...|:  ....|:|:.|       .|||||:.||:||.|.:||.:..:...||
 Worm   140 VFDNECEGKTTIPFYRAKYDKATGNGLNS-------PREQINERTSWIDGSFIYGTTQPWVSALR 197

  Fly   962 NLTSQEGLLRVGV--HFPRQKDMLPF---AAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLA 1021
            :.  ::|.|..||  :.|.....:|.   |.||    ..|.:..:.:  |:.||.||||..|||:
 Worm   198 SF--KQGRLAEGVPGYPPLNNPHIPLNNPAPPQ----VHRLMSPDRL--FMLGDSRVNENPGLLS 254

  Fly  1022 MHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQ 1086
            ...|..|.||..|:::.:.:..|..:.::|.||::|.|.||.|....::|.::||.  ..:..|.
 Worm   255 FGLILFRWHNYNANQIYREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGED--VRLSNYT 317

  Fly  1087 GYNPQLNPSIANEFATAALRFGHTIINPIL---HRLNE-TFQPIPQGH--LLLHKAFFAPWRLAY 1145
            .|.|.:.|.|::.|..||.||.|:|:.|.:   .|.|: .|:....|:  |.|.:.::....:..
 Worm   318 KYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEFRTEVGGYPALRLCQNWWNAQDIVK 382

  Fly  1146 EGGVDPLMRGFLAVPAKLKTPDQNLNTE-LTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYR 1209
            |..||.::   |.:.:::...|.|:..| |.:.:|...|...||:.|.:|.||||:|:|.||..|
 Worm   383 EYSVDEII---LGMASQIAERDDNIVVEDLRDYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELR 444

  Fly  1210 KLCNL------TVAQDFEDLAGEISSAEIRQKMKELYGHPDNV---DVWLGGILEDQVEGGKVGP 1265
            :...|      |:.:||.    :..:|:: :|:|||||  .|:   |.::||:|    |||:.||
 Worm   445 RTFGLAPKTWETMNEDFY----KKHTAKV-EKLKELYG--GNILYLDAYVGGML----EGGENGP 498

  Fly  1266 --LFQCLLVEQFRRLRDGDRLYYENP--GVFSPEQLTQIKQANFGRVL---CDVGDNFDQVTENV 1323
              :|:.::.:||.|:|||||.::||.  .:|:.|::..|.......::   .|:.:...|  ::|
 Worm   499 GEMFKEIIKDQFTRIRDGDRFWFENKLNRLFTDEEVQMIHSITLRDIIKATTDIDETMLQ--KDV 561

  Fly  1324 FILAK----------HQGGYKKCEDII-------GINLYLWQECGRCNSPPAIFDSYIPQTYTKR 1371
            |...:          :..|.:.|..:|       ....|::...|....|...:.  |.....:|
 Worm   562 FFFKEGDPCPQPFQVNTIGLEPCAPLIQSTYWDDNDTTYIYTLIGLACIPLICYS--IGHYMVER 624

  Fly  1372 SNRQKRDLGKEN--DEVATAESYDSPLESLYDVN 1403
            ..|    :|..:  |.:.|..|.:||..::|.||
 Worm   625 RIR----IGHNSACDSLTTDFSTESPKVNVYKVN 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380
		LRR	<55..>184	CDD:443914
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		Ig_3	235..311	CDD:464046
		Ig	366..450	CDD:472250
		Ig strand B	384..388	CDD:409544
		Ig strand C	397..401	CDD:409544
		Ig strand E	420..424	CDD:409544
		Ig strand F	434..439	CDD:409544
		Ig strand G	447..450	CDD:409544
		Ig_3	458..533	CDD:464046
		Ig	553..644	CDD:472250
		Ig strand B	570..574	CDD:409353
		Ig strand C	584..588	CDD:409353
		Ig strand E	610..614	CDD:409353
		Ig strand F	624..629	CDD:409353
		Ig strand G	638..641	CDD:409353
		peroxidasin_like	898..1338	CDD:188658	143/484 (30%)
		VWC	1465..1523	CDD:278520
duox-2	NP_490684.1	dual_peroxidase_like	41..596	CDD:188652	172/617 (28%)
		PTZ00183	<811..>903	CDD:185503
		COG4097	989..1405	CDD:443273
		NOX_Duox_like_FAD_NADP	1224..1408	CDD:99783