Protein Alignment Pxn and pxn-2

DIOPT Version :10

• Sequence 1: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Sequence 2: NP_509834.1
• Gene: pxn-2 / 181288
• WormBaseID: WBGene00004257
• Length: 1328
• Species: Caenorhabditis elegans
• Alignment Length: 1523
• Identity: 497/1523 - (32%)
• Similarity: 740/1523 - (48%)
• Gaps: 251/1523 - (16%)

  Fly    15 LLLAGGVQSVYCPAGCTCLERTVRCIRAKLSAVP-KLPQDTQTLDLRFNHIEELPANAFSGLAQL 78
            |||.|...|..||:.|.|....|.|....|:|:| .:|..|..|....|.:..|..:.|..|..|
 Worm     6 LLLIGISLSTACPSECRCAGLDVHCEGKNLTAIPGHIPIATTNLYFSNNLLNSLSKSNFQALPNL 70

  Fly    79 TTLFLNDNELAYLQDGALNGLTALRFVYLNNNRLSRLPATIFQRMPR-LEAIFLENNDIWQLPAG 142
            ..|.|::|.:..:::..|:....|:::.|:.|::..:|.  ....|. |.::.|.:|:|.:|...
 Worm    71 QYLDLSNNSIRDIEETLLDSFPGLKYLDLSWNKIRYVPK--LSTAPNALVSLNLVHNEISRLDND 133

  Fly   143 LFDNLPRLNRLIMYNNKLTQLPVDGFN--RLNNLKRLRLDGNAIDCNCGVY-------SLWRRWH 198
            |..:.|.:...::..|::..||.|.||  .:..||.:::.||...|:|.:.       ||:..
 Worm   134 LVSHSPYMQTFLIQRNRIQSLPHDFFNSRMVPTLKTVKMAGNPWSCDCRMVNVKQFADSLFAH-- 196

  Fly   199 LDVQRQLVSISLTCAAPQMLQNQGFSSLGEHHFKCAKPQFLVAPQDAQVAAGEQVELSC---EVT 260
               ..|.:.|...|..|:.|:|..|.:|...:.:|.||::      ::...| ..::||   |:.
 Worm   197 ---SNQNIFIVGKCFFPKGLRNYVFRNLSIENLECEKPEY------SKTDDG-MFKMSCPNNEME 251

  Fly   261 GLPRPQITWMHNTQELGLEEQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVV 325
            |.....| ::.|.:|  ....|.......||||.....|.:   |||....:..::..|. ::..
 Worm   252 GYHYDSI-FLENNKE--ARHTAHFARDKDGSLLSNGQFTRN---YQCAFYRQKQSIHMQK-KMQA 309

  Fly   326 NGGNHPLDSPIDARSNQVWADAGTPMHGATPLPSPLPSPPHFTHQ---PHDQIVALHGSGHVL-L 386
            :....|   ||...:.:....:.......|.....:.:.|....:   .|.|:......|..| |
 Worm   310 SSSTEP---PITTTTMEPMTTSTMDSMDTTESVVTMTTMPEIDTKIVFEHKQLDTTSRDGETLEL 371

  Fly   387 DCAASGWPQPDIQWFVNGRQLLQSTPSLQLQANGSLILLQP-NQLSAGTYRCEARNSLGSVQATA 450
            .|.|||.|.|.|.|....::|.:|... :|..|||::.:.| .....|.|.|.|.|...|.....
 Worm   372 KCEASGEPTPTITWLFEKQKLTESRKH-KLTKNGSVLKIFPFLNTDIGQYECVASNGEESKSHIF 435

  Fly   451 RIELK--ELPEILTAPQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENENTE 513
            .:.||  |.|.|:.||......:|:...|.|:|.|.|:|.:.|...|:.:|.......:.:.|.|
 Worm   436 SVSLKESEQPVIIDAPMDTNATIGQQVTLRCNAKGFPVPDVVWLFEGIRIPRRNTRYTISDNNIE 500

  Fly   514 LVVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIELPCQADQ 578
            |.:....:..:||:.|.|.|..|.                  |:..:||:.
 Worm   501 LTIEKVTRHDSGVFTCQAVNSVGS------------------AVATANLLV-------------- 533

  Fly   579 PEDGLQISWRHDGRLIDPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVT 643
               |.:::.:.|..|.|..::...|
 Worm   534 ---GAELTEKVDKLLDDSTIEKIAK---------------------------------------- 555

  Fly   644 IRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDK-APPNYGELLRVFRFPTGEAR- 706
                               ||.::::.|:::|.|   ..|.|| ..||  :|.::|:|.....:
 Worm   556 -------------------EAKQKVEKALSSTKD---QQRMDKIESPN--DLSKLFKFAINLKKV 596

  Fly   707 QLARAAEIYERTLVNIRKHVQEG--DNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPNCT 769
            .|.:|.||||.::..::.|:..|  ....|.|....:..:|...::..:.|.|||...:...:|.
 Worm   597 DLGKAREIYEESIRLVQMHIDNGLAFESAMISPNVSYEAVLPVSYVQTLMEKSGCQTGQFAESCE 661

  Fly   770 DMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLV 834
            |.||.|:|||.||.|||.:||.||.|..||.||.||.|||||:.||||.||..|:|:..|:||.|
 Worm   662 DHCFFSKYRSYDGQCNNHEHPWWGVSEMAFMRLLPPRYENGFNTPVGWEKGKRYNGYEVPNARKV 726

  Fly   835 STSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESW-DGIDCKKSCEMAPPCYPIEVP 898
            |..|:.|.|.||.:.::.|.||||||:||||....|:::..|: :|..|.::||.|.||:.|::.
 Worm   727 SRVLIGTDETTPHSHLSAMTMQWGQFIDHDLTLTAPALTRHSYKEGAFCNRTCENADPCFNIQLE 791

  Fly   899 PNDPRV-----RNRRCIDVVRSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQ 958
            .:||::     :...|::..|:.|.||||.||..|..|.:|:|:|.||||:|||.:||.|...|.
 Worm   792 ADDPKLHTGLYQKHPCMEFERNGAACGSGETSPIFQRVTYRDQLNLLTSYLDASGIYGNSEEQAL 856

  Fly   959 ELRNLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLD-ENTMSCFVSGDIRVNEQVGLLAM 1022
            |||:|.|..||||..:.....|..:||....| ||||||.. ||.:.||::||:|.|||:||::|
 Worm   857 ELRDLYSDHGLLRFDIVSGANKPYMPFEKDSD-MDCRRNFSRENPIKCFLAGDVRANEQLGLMSM 920

  Fly  1023 HTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGME-MMGEYQ 1086
            |||::||||||||:|.::|.:|||:|::||.||::||.:||||:..|||.|:|::... ::|||:
 Worm   921 HTIFLREHNRIASRLLEVNENWDGETIFQETRKLIGAMLQHITYNAWLPKILGKATYNTIIGEYK 985

  Fly  1087 GYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQGHLLLHKAFFAPWRLAYEGGVDP 1151
            ||||.:||:||||||||||||.||:||..|.|.::.|:...||||.||.|||||.||..||||||
 Worm   986 GYNPDVNPTIANEFATAALRFAHTLINTHLFRFDKDFKETKQGHLPLHNAFFAPERLVSEGGVDP 1050

  Fly  1152 LMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLCNLTV 1216
            |:||..|.|.|:..|||.||.|||||||...|.|||||||:|||||||||:|.:..|||.|||||
 Worm  1051 LLRGLFAAPIKMPRPDQVLNKELTEKLFNRFHEVALDLAALNIQRGRDHGLPSWTEYRKFCNLTV 1115

  Fly  1217 AQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRRLRDG 1281
            .:.:.|:...:.:..:..|::.|||..:|:|:|:||:.|.:.....:||...|::.:||:|||||
 Worm  1116 PKTWSDMKNIVQNDTVISKLQSLYGVTENIDLWVGGVTEKRTADALMGPTLACIIADQFKRLRDG 1180

  Fly  1282 DRLYYENPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTENVFILAKHQGG----YKKCEDIIGI 1342
            ||.:|||..:||..||.|||:....:::|..||:.|::..::|:   :.|.    |:.||.:..|
 Worm  1181 DRFWYENEEMFSKAQLRQIKKVTLSKIICTNGDDIDRIQRDIFV---YHGNSTQFYEPCESLPEI 1242

  Fly  1343 NLYLWQEC--GRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNEE 1405
            ||.:|..|  ..|:|               .|...:..:|  .||.|
 Worm  1243 NLNMWTTCCDAMCSS---------------SSTLARNAIG--GDEKA------------------ 1272

  Fly  1406 RVSGLEELIGSFQKELKKLHKKLRKLEDSCNSADSEPVAQVVQLAAAPPQLVSKPKRSHCVDDKG 1470
                         |..|:.|...:|   ||:                               |||
 Worm  1273 -------------KRRKRRHHHSKK---SCH-------------------------------DKG 1290

  Fly  1471 TTRLNNEVW--SPDVCTKCNCFHGQVNC 1496
            ..|.:.:.|  |.|:|.:|.|..|:|.|
 Worm  1291 KRRKSGDRWNHSNDICVECMCHDGEVWC 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		LRR	<55..>184	CDD:443914	32/131 (24%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		leucine-rich repeat	102..125	CDD:275380	4/22 (18%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		leucine-rich repeat	150..173	CDD:275380	6/24 (25%)
		Ig_3	235..311	CDD:464046	19/78 (24%)
		Ig	366..450	CDD:472250	26/88 (30%)
		Ig strand B	384..388	CDD:409544	2/4 (50%)
		Ig strand C	397..401	CDD:409544	1/3 (33%)
		Ig strand E	420..424	CDD:409544	2/3 (67%)
		Ig strand F	434..439	CDD:409544	2/4 (50%)
		Ig strand G	447..450	CDD:409544	0/2 (0%)
		Ig_3	458..533	CDD:464046	21/74 (28%)
		Ig	553..644	CDD:472250	8/90 (9%)
		Ig strand B	570..574	CDD:409353	0/3 (0%)
		Ig strand C	584..588	CDD:409353	0/3 (0%)
		Ig strand E	610..614	CDD:409353	0/3 (0%)
		Ig strand F	624..629	CDD:409353	0/4 (0%)
		Ig strand G	638..641	CDD:409353	0/2 (0%)
		peroxidasin_like	898..1338	CDD:188658	223/450 (50%)
		VWC	1465..1523	CDD:278520	13/34 (38%)
pxn-2	NP_509834.1	LRRNT	16..43	CDD:396168	9/26 (35%)
		leucine-rich repeat	28..44	CDD:275380	5/15 (33%)
		leucine-rich repeat	46..69	CDD:275378	6/22 (27%)
		LRR	<47..>175	CDD:443914	30/129 (23%)
		leucine-rich repeat	70..93	CDD:275378	5/22 (23%)
		leucine-rich repeat	94..116	CDD:275378	5/23 (22%)
		leucine-rich repeat	117..140	CDD:275378	6/22 (27%)
		leucine-rich repeat	141..154	CDD:275378	1/12 (8%)
		Ig	346..432	CDD:472250	27/86 (31%)
		Ig strand B	369..373	CDD:409367	2/3 (67%)
		Ig strand C	382..386	CDD:409367	1/3 (33%)
		Ig strand E	405..410	CDD:409367	1/4 (25%)
		Ig strand F	419..424	CDD:409367	2/4 (50%)
		I-set	445..533	CDD:400151	26/105 (25%)
		Ig strand B	462..466	CDD:409390	1/3 (33%)
		Ig strand C	475..479	CDD:409390	0/3 (0%)
		Ig strand E	498..503	CDD:409390	3/4 (75%)
		Ig strand F	513..518	CDD:409390	2/4 (50%)
		Ig strand G	526..529	CDD:409390	0/2 (0%)
		peroxidasin_like	798..1238	CDD:188658	221/443 (50%)