DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pxn and Robo4

DIOPT Version :10

Sequence 1:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster
Sequence 2:NP_001292144.1 Gene:Robo4 / 100911068 RGDID:6494870 Length:1021 Species:Rattus norvegicus


Alignment Length:1302 Identity:275/1302 - (21%)
Similarity:415/1302 - (31%) Gaps:463/1302 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   356 PLP---------SPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQWFVNGRQLLQST 411
            |||         ..|.|||.....|.||:  |.|||...:.|.|||.|.|.|:|.:||:.|..:|
  Rat    24 PLPLLLLFIMGGKALDSPPQILVHPQDQL--LQGSGPAKMSCRASGQPLPTIRWLLNGQPLSMAT 86

  Fly   412 PSLQ-LQANGSLILLQP----------NQLSA--GTYRCEARNSLG-SVQATARIELKELPE-IL 461
            |.|. ||::|:|:|.:|          |.|||  |.|.|||.|.|| :|...||:.:..|.| ..
  Rat    87 PDLHYLQSDGTLLLHRPPTHGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFR 151

  Fly   462 TAPQSQTIKLGKAFVLECDAD-GNPLPTIDWQLNGVPL---PGNTPDLQLENENTELVVGAARQE 522
            ..|:.....:|::.||||... |.|.|::.|..:|.||   ||     :.......|:|..|.:.
  Rat   152 IQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPG-----KRTVSGDSLMVARAEKN 211

  Fly   523 HAGVYRCTAHNENGETSVEATIKVERSQSPPQLAIEPSNLVAITGTTIEL---------PCQADQ 578
            ..|.|.|.|.|..|:....|. :|...:||...  |...|:|:   .|:|         |.:..:
  Rat   212 DTGTYMCMATNNAGQRESRAA-RVSIQESPDHK--EHLELLAV---RIQLENVTLLNPEPVKGPK 270

  Fly   579 PEDGLQISWRHDGRLI-------------DPNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLK 630
            |...:.:||:..|...             ||..|.:...::...|.|..|...:..|..||.:::
  Rat   271 PGPAVWLSWKVSGPAAPAQSYTALFRAQRDPRDQGSPWTEVLLDGLLNAKLGGLRWGQDYEFKVR 335

  Fly   631 NQFGRASA--SALVTIR----------NNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNR 683
            ...|||..  |.::.:|          ..|.|.||:..|.:::|                     
  Rat   336 PSSGRARGPDSNVLLLRLPEQVPSAPPQEVTLRPGNGSVFVSWA--------------------- 379

  Fly   684 SDKAPP--NYGELLRVFR-FPTGEARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLL 745
               .||  |:...:|.:: :..|.|...|.                    |.|:..|:.:     
  Rat   380 ---PPPAENHNGFIRGYQVWSLGNASLPAA--------------------NWTVVGEQTQ----- 416

  Fly   746 SREHLHLVAELSG--CME----------HREMPNC-----------TDMCFHSRYRSIDGTCNNL 787
                |.:.|.:.|  |::          ...:|.|           .|...|..: :::.....|
  Rat   417 ----LEIAARMPGSYCVQVAAVTGAGAGEPSIPVCLLLEQAMEQSARDPSKHVSW-TLEQLRATL 476

  Fly   788 QHP---------TW----GASLTAFRR------LAPPIYENGFSMPVGWTKGMLYSGHAKPSARL 833
            :.|         .|    |.::..:||      |.|.:|                          
  Rat   477 KRPEVIASGAVLLWLLLLGIAVCIYRRRKAGVHLGPGLY-------------------------- 515

  Fly   834 VSTSLVATKEITPDARITHMVMQWGQFLDHDLDHAIPSVSSESWDGI----DCKKSCEMAPPCYP 894
                    :..:.||           .|.|.:||:.....:::|...    |...|..::.   .
  Rat   516 --------RYTSEDA-----------ILKHRMDHSDSPWLADTWRSTSGSRDLSSSSSLSS---R 558

  Fly   895 IEVPPNDPRVRNRRCID-VVRSSAICGSGMTSLFFDSVQHREQINQLTSY--IDASQVYGYSTAF 956
            :.|.|.||....|..|. ..||..:.....||.|:.|:     |.:.||.  :..|.    .|..
  Rat   559 LGVDPRDPLDGRRSLISWDPRSPGVPLLPDTSTFYGSL-----IAEQTSSPPVRPSP----QTPA 614

  Fly   957 AQEL-RNLTSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLL 1020
            |:.| ..||....               |:|: .|.:..||.|....||               |
  Rat   615 ARRLPPKLTGTSS---------------PWAS-SDSLCSRRGLCSPRMS---------------L 648

  Fly  1021 AMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEM---- 1081
            |....|..:..:   :|.|.||.                           ||:.|...||:    
  Rat   649 APAEAWKAKKKQ---ELHQANSS---------------------------PLLRGSHPMEIWAWE 683

  Fly  1082 MGEYQGYN----PQLNPSIANEFATAALRFGHTIINPILHRLNETF--QPIPQGHLLLHKAFFAP 1140
            :|.....|    |..|.....|...|.:.:  ..:.|.|||.:...  :|:|            |
  Rat   684 LGSRASKNLSQSPGPNTCSPREAPGAVVAW--RALGPQLHRNSSELAARPLP------------P 734

  Fly  1141 WRLAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGY 1205
            ..|:..|                 .|..:..::..||| |...:..|..|.:::........|  
  Rat   735 TPLSLRG-----------------APSHDPQSQCVEKL-QAPSSDPLPAAPLSVLNSSRPSSP-- 779

  Fly  1206 NVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCL 1270
                :...|:|....   :..:||:.:..                   ||::.:...:.|....|
  Rat   780 ----QASFLSVPSPG---SSNLSSSSLSS-------------------LEEEDQDSVLTPEEVAL 818

  Fly  1271 LVEQFRRLRDGDRLYYENP-GVFSPEQLTQIKQANFGRV-------LCDVGDNFDQVTENVFILA 1327
            .:|    |.||:    |.| ...||........|.:|.:       |.|:|              
  Rat   819 CLE----LSDGE----ETPTNSVSPMPRAPSPPATYGYISIPTSSGLADMG-------------- 861

  Fly  1328 KHQGGYKKCEDIIGINLYLWQECGRCNSPPAIFDSYIPQTYTKRSNRQKRDLGKENDEVATAESY 1392
             ..||        |:.    .|.|....||.:..:..|                  .|.:.|..:
  Rat   862 -RAGG--------GVG----SEVGNLLCPPRLCPTPTP------------------SEGSLANGW 895

  Fly  1393 DSPLESLYDVNEERVSGLEELIGSFQKELKKLH--KKLRKLEDSCN-SADSEPVAQVVQLAAAPP 1454
            .|..|.  :|...|.|.:....|||   |...|  :.|....||.. |.:......|...|::||
  Rat   896 GSASED--NVPSARASLVSSSDGSF---LADAHFARALAVAVDSFGFSLEPREADCVFTDASSPP 955

  Fly  1455 QLVSKPKRSHCVDDKGTTR---LNNEVWSPDVCTKCNCFHGQVNCLRERCGEVSCPPGVDPLTPP 1516
                .|:     ||...||   |....|.||........|.|      |.|.     |:.| .||
  Rat   956 ----SPR-----DDLSLTRSFSLPLWEWRPDWLEDAEINHTQ------RLGR-----GLPP-WPP 999

  Fly  1517 EA 1518
            ::
  Rat  1000 DS 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PxnNP_523891.2 leucine-rich repeat 54..77 CDD:275380
LRR <55..>184 CDD:443914
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
leucine-rich repeat 126..149 CDD:275380
leucine-rich repeat 150..173 CDD:275380
Ig_3 235..311 CDD:464046
Ig 366..450 CDD:472250 40/97 (41%)
Ig strand B 384..388 CDD:409544 0/3 (0%)
Ig strand C 397..401 CDD:409544 1/3 (33%)
Ig strand E 420..424 CDD:409544 2/3 (67%)
Ig strand F 434..439 CDD:409544 2/4 (50%)
Ig strand G 447..450 CDD:409544 0/2 (0%)
Ig_3 458..533 CDD:464046 23/79 (29%)
Ig 553..644 CDD:472250 23/114 (20%)
Ig strand B 570..574 CDD:409353 2/12 (17%)
Ig strand C 584..588 CDD:409353 1/3 (33%)
Ig strand E 610..614 CDD:409353 2/3 (67%)
Ig strand F 624..629 CDD:409353 2/4 (50%)
Ig strand G 638..641 CDD:409353 1/4 (25%)
peroxidasin_like 898..1338 CDD:188658 86/461 (19%)
VWC 1465..1523 CDD:278520 16/57 (28%)
Robo4NP_001292144.1 Ig 42..144 CDD:472250 43/103 (42%)
Ig strand B 59..63 CDD:409490 0/3 (0%)
Ig strand C 72..76 CDD:409490 1/3 (33%)
Ig strand E 96..100 CDD:409490 2/3 (67%)
Ig strand F 122..127 CDD:409490 2/4 (50%)
Ig strand G 136..139 CDD:409490 0/2 (0%)
Ig 151..236 CDD:472250 26/90 (29%)
Ig strand B 165..169 CDD:409389 2/3 (67%)
Ig strand C 179..183 CDD:409389 0/3 (0%)
Ig strand E 201..205 CDD:409389 1/3 (33%)
Ig strand F 215..220 CDD:409389 2/4 (50%)
Ig strand G 229..232 CDD:409389 0/2 (0%)
fn3 361..443 CDD:394996 20/134 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..563 3/21 (14%)
PHA03247 <578..861 CDD:223021 78/420 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..634 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..810 19/141 (13%)
Blue background indicates that the domain is not in the aligned region.

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