DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1317 and doa10

DIOPT Version :9

Sequence 1:	NP_001163328.1	Gene:	CG1317 / 38300	FlyBaseID:	FBgn0035333	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_596733.1	Gene:	doa10 / 2539855	PomBaseID:	SPBC14F5.07	Length:	1242	Species:	Schizosaccharomyces pombe

Alignment Length:	1322	Identity:	274/1322 - (20%)
Similarity:	474/1322 - (35%)	Gaps:	452/1322 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDLSQGDICRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPIY 66
            ||    :||||||||..||.|||:||.|||||:|:||:||:.|:.:|.|.:||||...|.|..:|
pombe     4 DD----EICRVCRCEGAPDSPLFHPCKCTGSIRYVHQECLVEWLGHSKKTHCELCKAKFEFTKVY 64

  Fly    67 APDMPRVLPIKDVLVGLMSAVLEGARCWLHYTLVGLAWFGVVPLSAYRTYRYLFRASSFDMI--- 128
            :..|||.:|...:...|.|.:.:....:....|....|..::||.....:...|:......|
pombe    65 SESMPRTIPFTILCRKLASTLKQRVIFFTRVLLTFFCWTVLLPLIFKHVWNLNFKIGDTYTIHAR 129

  Fly   129 ---LTLP-----FDIFS-------VENLASDAFRG---CFVVTCTLL-SFIGLVWLREQI----- 169
               .|.|     |:..|       :..|.::...|   .||||..|: :|:...|:.:..
pombe   130 NKTFTAPQKPGYFESISQITSSPRLNTLIANTAEGQVLTFVVTFILITAFLVREWVLQNAVQVAD 194

  Fly   170 -LHGGGPDWLERDDAPLQAAAANPAPDPAAEAAP------------------------------- 202
             |.|...:.:.:::....||||........||..
pombe   195 ELQGQQFENVNQNNQAQAAAAAAQNLREVREARQRLAMVMEHLRERQEQRNLELQRNGSFEEIER 259

  Fly   203 -------------QPQDDNNNADDNE--------APAPADNDGQ--------------------- 225
                         :||::.|:.|.:|        .||...||..
pombe   260 ARQRFALLGDNIREPQEEENDVDVDEIFNRQQLNQPALDLNDANSSNSVPVEFNSLHSQNVDYRD 324

  Fly   226 -----------DAQAQ------------DAAPAAA------------APVVDADADEQNWNPMEW 255
                       |.|:.            |.|...|            .|::..:.||...|..|.
pombe   325 EVDSLRPQFNVDEQSSISHSSNASENIVDGAVTQANGIESDFTRVDHEPIIVNNDDENGNNESEN 389

  Fly   256 DRAAEELTWER---------------------------------------LLGLDGSLV-FLEHV 280
            :...||....|                                       .|||.|.:. ||::.
pombe   390 EEVIEEDNLNRNVIAEAQNQVVADEERNAVARAAQIAEADDADDFDGILEFLGLRGPITGFLQNC 454

  Fly   281 FWIISLNTMFIFTFAFCPYCVG------------------NFILSSMDLL--------------Q 313
            ..|..:.::|:.|....||..|                  .||||.:::|              .
pombe   455 LVIAFVVSVFLTTAVGIPYMSGRLMVEWILFIIHRPTFILRFILSFVNILFDWTVGGAFNIVKIL 519

  Fly   314 PEKPL-------LHFHGLITTLFG---------------------------YCCIGLTLVVLHFF 344
            .:.||       |...|:.::.|.                           |...|...||..|
pombe   520 TKLPLLSTVFVKLKLQGIFSSSFQQVSNNMYSWIYDHVFSSSDHAYESLIYYMKTGHKQVVQSF- 583

  Fly   345 SRVFRLRRVC--------------------------------WFIGLCYI--------------- 362
             .:|.:.|||                                .|:|:.|:
pombe   584 -SIFPVFRVCQMFAVILKDFVENYSNRPVDRVFTTLIGYCMFTFLGISYLNRKQFLFNDPQIRNV 647

  Fly   363 -------------VVKVSLLSVLEIGVLPLICGWWLDICSLPLLDASLKDRKES----FKAAPGT 410
                         :.|..::..:|:.|.|:.||..|.:|   |:....|...|:    ....|..
pombe   648 ELAFREVLRQCGSIAKFGIIFSIELVVFPIFCGILLSMC---LIGTFKKLAAENLLNVMTVYPAQ 709

  Fly   411 SLFVHWMFGMVYVYYFAAFVSLLREVLRPGVLWIFRNVNDPDFSPIQEMIHVPIVRHIRRLVASA 475
            |:|:.|..|:.:::.||.|:|::|:::|||||:..|:.|||.|.||:|::..|::..::::..||
pombe   710 SIFLAWFIGITFMFEFAVFISMVRKIVRPGVLYFLRDPNDPQFHPIREILEKPMLFQLKKIGFSA 774

  Fly   476 MIFGFAVLLMLWLPIRILQ---VVCP-DFLPYALSGDSAVNLQ----LLLLQIVLPGFFEQTQTR 532
            :::...::..:...|.:|:   ::.| :|.......::.::|.    |:.|.|.|  |.....||
pombe   775 ILYFAFIIGCVGSVIHLLKSTGIIFPIEFTTKPAVFEAPIDLLALEILIFLSIKL--FKPLELTR 837

  Fly   533 IWLKGLLRIWCTAVAWLLGIRSYLLPAPEPEPEIPAAGEEG------------VENAAGENENQ- 584
            .:.:.|:..:|..    |.:.||::.....:       |||            :.:...:.|||
pombe   838 SFWRTLVSTFCRC----LRLSSYVMGQRYSD-------EEGYYPKQYFSFLRRIISKPSDTENQD 891

  Fly   585 EGEAADAAAQ----------PPAPPPPPPPPVEPAPAPRNLAAAHQAIMQRDAPVGFQPYDK--- 636
            :|:...|...          |.....|........|...|               |::.:.:
pombe   892 DGDKQKAKKDFVQDGFFLWCPSKDVVPVRQGAMLIPVTEN---------------GYEIFGEKKK 941

  Fly   637 ------------PSLFALRLCALLALMCLSIVCAAMLTLT---VPVYIGRRLMLIWSSQPDEKAA 686
                        ||.|..||.||| |.|.  :|:.::|:.   ||:.:||.: ..|...
pombe   942 VEENADYTITYAPSNFYKRLIALL-LFCW--ICSTLVTVLLVFVPLSLGRAI-YAWCFP------ 996

  Fly   687 GAAAAEGAGEVVENLDPIDPEGARKNERLLRSHELYTAELGGY-LCWIVCRVVAAVVTLLPQGRA 750
                     .||:                   |:.|...:|.| :.:.:..:.|:|..|......
pombe   997 ---------NVVK-------------------HDFYAYAIGFYSISFPMYAIHASVKFLKLDYLR 1033

  Fly   751 AIVDK--IKHWVR---VALQYALPVLTLLGIFVLVPLLIGLLIELAVVIPLRVPLRKTPIHF-LW 809
            ::::|  :|..:|   :||:|.|  |..||||:| |||:|.:.||.|.||.|....:..:.. .:
pombe  1034 SLMNKLNLKIVMRSLVMALKYLL--LAFLGIFIL-PLLLGAIWELYVAIPFRTIFNRGTLALDAF 1095

  Fly   810 EDWALGVLYCKIAIALTMMGPDWHLKRALDRAYMDGLRDF----DLKFVMRDLAVPVVTTIGLAL 870
            ::|.:|:...:: |..|:...:   :|.:.|.:.|..||.    .:..:::::.:|..:.:..|:
pombe  1096 QNWVIGLFMLRM-IYFTVTSNE---ERFVSRLFQDAFRDRWTNPQILPLLKNVLIPFTSALIAAV 1156

  Fly   871 AIPYVMAHMMFPIFLADAY---AQHVVARLVYPVSFIVVGSICILLFQIDQLKKLYLSIKVDKYL 932
            .:|.|..::.:| ||:..:   ::.::.||::|:...::|...:....::...|....|:.|.||
pombe  1157 VLPSVFTYVTYP-FLSSIFPSASKTLMYRLMHPIFLALLGLALLGRRFVETSSKWSQGIRDDLYL 1220

  Fly   933 VGQRLVNYEHRKKQQQQQEEEK 954
            ||.||.|:.........:..||
pombe  1221 VGTRLHNFGESAPPAISESAEK 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1317	NP_001163328.1	RINGv	9..56	CDD:128983	30/46 (65%)
CG1317	NP_001163328.1	DotA_TraY	<737..913	CDD:275142	46/188 (24%)
doa10	NP_596733.1	SSM4	1..1239	CDD:227510	272/1317 (21%)
doa10	NP_596733.1	RINGv	7..55	CDD:128983	31/47 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	122	1.000	Domainoid score	I1433
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I869
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003180
OrthoInspector	1	1.000	-	-		oto101208
orthoMCL	1	0.900	-	-		OOG6_102767
Panther	1	1.100	-	-	LDO	PTHR13145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R328
SonicParanoid	1	1.000	-	-		X3077
TreeFam	1	0.960	-	-
	12	11.850