DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1317 and marc-6

DIOPT Version :9

Sequence 1:	NP_001163328.1	Gene:	CG1317 / 38300	FlyBaseID:	FBgn0035333	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_492823.2	Gene:	marc-6 / 172986	WormBaseID:	WBGene00018847	Length:	1025	Species:	Caenorhabditis elegans

Alignment Length:	1059	Identity:	356/1059 - (33%)
Similarity:	533/1059 - (50%)	Gaps:	205/1059 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDLSQGDICRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPI 65
            :||.....:|||||..   :..|:|||:|||||||:||:||:.|::||.||.||||::.:|||||
Worm    44 IDDNDDHLMCRVCRGN---EGSLYYPCLCTGSIKYVHQECLVEWLKYSKKEVCELCNHKYSFQPI 105

  Fly    66 YAPDMPRVLPIKDVLVGLMSAVLEGA---RCWLHYTLVGLAWFGVVPLSAYRTYRYLFRASSFDM 127
            |..|||:.|||.::|.|::   :.||   |.|:.||:|...|.|:|||:|.|.|..:|..|..|
Worm   106 YRQDMPKALPILEILRGVL---ISGAIMVRTWIIYTIVMTTWLGIVPLTAARIYNCIFYLSFHD- 166

  Fly   128 ILTLPFDIFSVENLASDAFRGCFVVTCTLLSFIGLVWLREQILHGGGPDWL-------------- 178
            |:..||.:|..|:..:|..:|..::...:.:||.||||||||:.||...:|
Worm   167 IVNAPFQLFKAEHFFNDILKGSLLLLVFVCTFISLVWLREQIIIGGPQHFLNIEAEENEGEDDVV 231

  Fly   179 ------------------------ERDDAPLQAAAANPAPDPAAEAAPQ---------------- 203
                                    |.|:...:.:.:....||..|...:
Worm   232 NENNESSDESEDDEEDEDDEEDDDEDDEEEEEDSESGYEEDPVPEFREEGEAYVARRRVPFEERR 296

  Fly   204 -----------PQ-----------DDNN----------NADDNEAPAPADND------------- 223
                       ||           ||.|          |..::..|.|.:.:
Worm   297 RDILEARHGFRPQMPNLGIYDDMRDDENEVLENDHVLQNVQEDRIPPPMEPEPIVPRAAARANRR 361

  Fly   224 -GQDAQAQDAAPAAAAPVVDADADEQNWNPMEWDRAAEELTWERLLGLDGSLVFLEHVFWIISLN 287
             .:..:.::||.||||......|.:|..|..||||..:||||:|||||||||:|||||||:||||
Worm   362 IRRQRENEEAAAAAAAAQEQGGAGDQEDNWREWDRFGDELTWQRLLGLDGSLIFLEHVFWVISLN 426

  Fly   288 TMFIFTFAFCPYCVGNFILSSMDLLQPEKPLLHFHGLITTLFGYCCIGLTLVVLHFFSRVFRLRR 352
            |:|..|||:.|:.:||:.||.:.|   ...:.:|..::..|.||..|.:...|:|.....|:::.
Worm   427 TLFTATFAYFPFRIGNWFLSVIGL---HGKISYFPSIVAMLLGYIQIAIITYVIHQIMLQFKMKM 488

  Fly   353 VCWFIGLCYIVVKVSLLSVLEIGVLPLICGWWLDICSLPLLDASLKDRKESFKAAPGTSLFVHWM 417
            :..|:|:.::::||.||..||||..|::||.|:|:|:|||.:.:|..|..:|..||..|:|:|||
Worm   489 MYRFLGIMFLIIKVFLLVFLEIGFFPVMCGCWMDVCTLPLFNITLSQRIATFATAPFMSIFLHWM 553

  Fly   418 FGMVYVYYFAAFVSLLREVLRPGVLWIFRNVNDPDFSPIQEMIHVPIVRHIRRLVASAMIFGFAV 482
            .|||||:|.|:||.||||:|||||||..||:|||||:||||||.:|..||.||||.|..:|...:
Worm   554 VGMVYVFYSASFVILLREILRPGVLWFMRNLNDPDFNPIQEMIDLPFTRHFRRLVVSTTLFFSTI 618

  Fly   483 LLMLWLPIRILQVVCPDFLPYALSGD-----SAVNLQLLLLQIVLPGFFEQTQTRIWLKGLLRIW 542
            ||:.::|:.|:..:.|..|||.:|..     |.::|:||:||:|:|...|....|.::|..:|.|
Worm   619 LLIFYIPLNIISSLIPSLLPYNVSMSAETPLSEISLELLILQVVMPAILEHANGRGFIKYGVRFW 683

  Fly   543 CTAVAWLLGIRSYLLPAPEPEPEIPAAGEEGVENAAGENENQEGEAADAAAQPPAPPPPPPPPVE 607
            |..|...|.:..|||             .:...|....|.|..                     :
Worm   684 CKVVGAALDLDQYLL-------------SDNNNNNQNNNNNNN---------------------D 714

  Fly   608 PAPAPRN-----LAAAHQAIMQRDAPVGFQPYDKPSLFALRLCALLALMCLSIVCAAMLTLTVPV 667
            |..|..|     |||.|||::....|..::||::||||.:|:..||.||.|:...::::...||.
Worm   715 PLRAGNNQAGGGLAAEHQALLLLREPRAYEPYNRPSLFGVRVSILLVLMSLTTTLSSVVVFIVPA 779

  Fly   668 YIGRRLMLIWSSQPDEKAAGAAAAEGAGEVVENLDPIDPEGARKNERLLRSHELYTAELGGYLCW 732
            .|||.::|:.|.|.:                                   .||:||..||.|:||
Worm   780 SIGRFIILMVSGQTN-----------------------------------VHEMYTVSLGLYVCW 809

  Fly   733 IVCRVVAAVVTLLPQG-----RAAIVDKIKHWVRVALQYALPVLTLLGIFVLVPLLIGLLIELAV 792
            .:.: ..||||...:|     :.|:|    |:..:.::.   .|..:.|.:::|||:|...:|..
Worm   810 TIGK-FGAVVTKFVRGGPHLFKRAVV----HYSYLGMRL---FLVAIPIIIVLPLLMGTYFQLVF 866

  Fly   793 VIPLRVPLRKTPIHFLWEDWALGVLYCKIAIALTMMGPDWHLKRALDRAYMDGLRDFDLKFVMRD 857
            ..|:|:..::|.:.|.::|||:||:..||...:.:|||||.||..||.....|:.:|....|...
Worm   867 FTPMRLGYQQTALMFPYQDWAMGVVQIKIFGVIAVMGPDWWLKTELDLLVQRGIENFAALHVFVR 931

  Fly   858 LAVPVVTTIGLALAIPYVMAHMMFPIFLADAYAQHVVARLVYPVSFIVVGSICILLFQIDQLKKL 922
            :.||.:..:...:|.|.|:......|..||.....::.|..||....:..::..:.:|:.:.::|
Worm   932 IVVPCILYLSTFIAFPVVVIKFYAFISGADPEFTMLLLRFSYPAFLFITSAVVFIRWQVVKFREL 996

  Fly   923 YLSIKVDKYLVGQRLVNYE 941
            ...||.|:||||.:|||||
Worm   997 AEKIKNDRYLVGTQLVNYE 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1317	NP_001163328.1	RINGv	9..56	CDD:128983	27/46 (59%)
CG1317	NP_001163328.1	DotA_TraY	<737..913	CDD:275142	49/180 (27%)
marc-6	NP_492823.2	SSM4	47..1016	CDD:227510	354/1056 (34%)
marc-6	NP_492823.2	RING_CH-C4HC3_MARCH6	52..98	CDD:319616	29/48 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165221
Domainoid	1	1.000	572	1.000	Domainoid score	I107
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4301
Inparanoid	1	1.050	643	1.000	Inparanoid score	I438
Isobase	1	0.950	-	0	Normalized mean entropy	S3502
OMA	1	1.010	-	-		QHG55388
OrthoDB	1	1.010	-	-		D170933at2759
OrthoFinder	1	1.000	-	-		FOG0003180
OrthoInspector	1	1.000	-	-		oto17765
orthoMCL	1	0.900	-	-		OOG6_102767
Panther	1	1.100	-	-	LDO	PTHR13145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R328
SonicParanoid	1	1.000	-	-		X3077
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750