DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1317 and AgaP_AGAP007204

DIOPT Version :9

Sequence 1:	NP_001163328.1	Gene:	CG1317 / 38300	FlyBaseID:	FBgn0035333	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	XP_308581.3	Gene:	AgaP_AGAP007204 / 1269927	VectorBaseID:	AGAP007204	Length:	973	Species:	Anopheles gambiae

Alignment Length:	959	Identity:	559/959 - (58%)
Similarity:	689/959 - (71%)	Gaps:	61/959 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QGDICRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPIYAPDM 70
            :||||||||||||.|||||:|||||||||:|||||||.|||||.|||||||.:.|||.|||:|||
Mosquito     2 EGDICRVCRCEAQSDRPLFHPCICTGSIKWIHQDCLMQWMRYSRKEYCELCGHRFSFTPIYSPDM 66

  Fly    71 PRVLPIKDVLVGLMSAVLEGARCWLHYTLVGLAWFGVVPLSAYRTYRYLFRASSFDMILTLPFDI 135
            |||||:|.|..||:|:|....:.|:|||:|.:||.|:|||:||||||:|| :.|.:|:|:||.|:
Mosquito    67 PRVLPLKYVAKGLLSSVGRAVKYWIHYTIVAVAWLGIVPLTAYRTYRFLF-SGSIEMVLSLPIDM 130

  Fly   136 FSVENLASDAFRGCFVVTCTLLSFIGLVWLREQILHGGGPDWLERDDAPLQAAAANPAPDPAAEA 200
            ||.||:..|.|||||||||||.:||||:||||||:||||||||||||...:.....|.| |.|..
Mosquito   131 FSTENITMDVFRGCFVVTCTLFTFIGLIWLREQIIHGGGPDWLERDDPQAEPLRRRPVP-PRAAN 194

  Fly   201 APQPQDDNNNADDNEAPAPADNDGQDAQAQDAAPAAAAPVVD--ADADEQNWNPMEWDRAAEELT 263
            ..:|..||...|..|.|.|     |.|.|.:...||.....|  |.|||.|||||||:|||||||
Mosquito   195 FGEPPADNVPIDPAEPPPP-----QPALADEPPEAAINEPGDGEAAADEANWNPMEWERAAEELT 254

  Fly   264 WERLLGLDGSLVFLEHVFWIISLNTMFIFTFAFCPYCVGNFILSSMDLLQPEKPLLHFHGLITTL 328
            ||||||||||:||||||||::||||.||..||||||.:|||:::.:.:..|.|.|.:||||:||:
Mosquito   255 WERLLGLDGSMVFLEHVFWVVSLNTAFIVLFAFCPYSIGNFLITFLGINAPGKQLTYFHGLLTTM 319

  Fly   329 FGYCCIGLTLVVLHFFSRVFRLRRVCWFIGLCYIVVKVSLLSVLEIGVLPLICGWWLDICSLPLL 393
            .|||.||:|||.||..:|..|.||....:||||||||||||||:|||||||:|||||||||||:.
Mosquito   320 LGYCVIGITLVKLHAIARFLRWRRQRRILGLCYIVVKVSLLSVVEIGVLPLVCGWWLDICSLPMF 384

  Fly   394 DASLKDRKESFKAAPGTSLFVHWMFGMVYVYYFAAFVSLLREVLRPGVLWIFRNVNDPDFSPIQE 458
            ||:|||||.|||.|||||||:|||||||||||||.|:.||||||||||||..||:||||||||||
Mosquito   385 DATLKDRKASFKVAPGTSLFIHWMFGMVYVYYFATFIVLLREVLRPGVLWFLRNLNDPDFSPIQE 449

  Fly   459 MIHVPIVRHIRRLVASAMIFGFAVLLMLWLPIRILQVVCPDFLPYALSGDSAVN---LQLLLLQI 520
            |||:.|:||.|||::||.|||.|||||||.||:||:...|.||||.|||||.||   |||||||.
Mosquito   450 MIHLSILRHTRRLISSATIFGSAVLLMLWAPIQILKTFWPTFLPYTLSGDSEVNELSLQLLLLQF 514

  Fly   521 VLPGFFEQTQTRIWLKGLLRIWCTAVAWLLGIRSYLLPAPEPEPEIPAAGEEGVENAAGENENQE 585
            |||.||||:.||||||||:||||..|:.:|||:||||.| :|:|                ||:
Mosquito   515 VLPSFFEQSHTRIWLKGLVRIWCNVVSRMLGIKSYLLGA-DPQP----------------NED-- 560

  Fly   586 GEAADAAAQPPAPPPPPPPPVEPAPAPRNLAAAHQAIMQRDAPVGFQPYDKPSLFALRLCALLAL 650
                |||          |||.:...|...||||||||||||.|||||||::|..||:||..||.|
Mosquito   561 ----DAA----------PPPRQQPDAGAGLAAAHQAIMQRDVPVGFQPYERPKFFAVRLIGLLVL 611

  Fly   651 MCLSIVCAAMLTLTVPVYIGRRLMLIWSSQPDEKAAGAAAAEGAGEVVENLDPIDPEGARKNERL 715
            ||:|:...::..||:||:|||..|.:.|......|...:|....|                .|..
Mosquito   612 MCISLAIGSLAILTIPVWIGRYGMALGSIGSSNIAPPPSAVSSTG----------------TETP 660

  Fly   716 LRSHELYTAELGGYLCWIVCRVVAAVVTLLPQGRAAIVDKIKHWVRVALQYALPVLTLLGIFVLV 780
            .|.||||||.:|.||||::.|.:|..|.|:||||||::.:||||:.:...|||.:...:.:..::
Mosquito   661 ARPHELYTAAIGMYLCWLISRGIALAVNLVPQGRAAVIARIKHWISIGTSYALAMFVFVLMLGVI 725

  Fly   781 PLLIGLLIELAVVIPLRVPLRKTPIHFLWEDWALGVLYCKIAIALTMMGPDWHLKRALDRAYMDG 845
            ||:.|||:||.||||||||..:||:.|||:||||||||.|||.|||:|||||.||||:::||.||
Mosquito   726 PLMFGLLLELVVVIPLRVPPDQTPVLFLWQDWALGVLYTKIACALTLMGPDWALKRAIEQAYRDG 790

  Fly   846 LRDFDLKFVMRDLAVPVVTTIGLALAIPYVMAHMMFPIFLADAYAQHVVARLVYPVSFIVVGSIC 910
            |||.:|.|::|:|.:||:|..|||||:|||:||.:.|:|..:...:.:::|.:||...::...|.
Mosquito   791 LRDINLNFIVRELGIPVITCFGLALAVPYVIAHSILPVFFPNPLTRTLISRQIYPFFLLIAFVIG 855

  Fly   911 ILLFQIDQLKKLYLSIKVDKYLVGQRLVNYEHRKKQQQQQEEEKEQQRA 959
            |::.|:.|.:|||::||.||||||||||||:|::|:::......|.|.|
Mosquito   856 IVVLQVRQFRKLYVAIKNDKYLVGQRLVNYDHQRKKRRPSVVATEAQEA 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1317	NP_001163328.1	RINGv	9..56	CDD:128983	41/46 (89%)
CG1317	NP_001163328.1	DotA_TraY	<737..913	CDD:275142	90/175 (51%)
AgaP_AGAP007204	XP_308581.3	RINGv	5..53	CDD:128983	42/47 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	1024	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4301
Inparanoid	1	1.050	1130	1.000	Inparanoid score	I695
OMA	1	1.010	-	-		QHG55388
OrthoDB	1	1.010	-	-		D170933at2759
OrthoFinder	1	1.000	-	-		FOG0003180
OrthoInspector	1	1.000	-	-		otm50397
Panther	1	1.100	-	-	LDO	PTHR13145
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3077
TreeFam	1	0.960	-	-
	13	12.940