DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1317 and march6

DIOPT Version :9

Sequence 1:	NP_001163328.1	Gene:	CG1317 / 38300	FlyBaseID:	FBgn0035333	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	XP_005163506.1	Gene:	march6 / 100002072	ZFINID:	ZDB-GENE-070912-530	Length:	936	Species:	Danio rerio

Alignment Length:	994	Identity:	469/994 - (47%)
Similarity:	623/994 - (62%)	Gaps:	124/994 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDLSQGDICRVCRCEAQPDRPLFYPCICTGSIKYIHQDCLMLWMRYSHKEYCELCSYSFSFQPI 65
            ||...:.|||||||.|...|:||::||:||||||:|||:||:.|:::|.|||||||.:.|:|.||
Zfish     1 MDTAEEADICRVCRSEGTQDKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPI 65

  Fly    66 YAPDMPRVLPIKDVLVGLMSAVLEGARCWLHYTLVGLAWFGVVPLSAYRTYRYLFRASSFDMILT 130
            |:||||..||::|:..||::::....|.|.|||||..||.|||||:|.|.|:.|| ..|...:||
Zfish    66 YSPDMPSRLPVQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLF-TGSVSSLLT 129

  Fly   131 LPFDIFSV---------ENLASDAFRGCFVVTCTLLSFIGLVWLREQILHGGGPDWLERDDAPLQ 186
            ||.|:.|.         |||.:|..:|||||||||.:||.||||||||:|||.|.|||::    |
Zfish   130 LPLDMLSTYVPDRTALRENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPLWLEQN----Q 190

  Fly   187 AAAANPAPDPAAEAAPQPQDDNNNADDNEAPAPADNDGQDAQAQDAAPAAAAP------------ 239
            ...|| |..|..||   |...|..|::...||||:...::|.|.:|....|.|
Zfish   191 QQPAN-AAGPPNEA---PGQGNGGAENQPMPAPAEPPAENAAAAEAPDLPADPAEEMELDNEDED 251

  Fly   240 ------VVDAD---ADEQNWNPMEWDRAAEELTWERLLGLDGSLVFLEHVFWIISLNTMFIFTFA 295
                  |.||:   .|:.|||.:|||||||||||||:|||||||||||||||::||||:||..||
Zfish   252 DGGAEDVADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFA 316

  Fly   296 FCPYCVGNFILSSMDLLQPEKPLLHFHGLITTLFGYCCIGLTLVVLHFFSRVFRLRRVCWFIGLC 360
            ||||.:|:|.:..:...:..: ..||.|||||:.||..:.:||:|.|..:.:.|.:|....:|:|
Zfish   317 FCPYHIGHFSVVGLGFEEYVR-ASHFEGLITTIVGYVLLAITLIVCHGLAALVRFQRSRRLLGVC 380

  Fly   361 YIVVKVSLLSVLEIGVLPLICGWWLDICSLPLLDASLKDRKESFKAAPGTSLFVHWMFGMVYVYY 425
            |||||||||.|:||||.|||||||||||||.:.|||||||:.||::||||::|:||:.|||||:|
Zfish   381 YIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDASLKDRELSFESAPGTTMFLHWLVGMVYVFY 445

  Fly   426 FAAFVSLLREVLRPGVLWIFRNVNDPDFSPIQEMIHVPIVRHIRRLVASAMIFGFAVLLMLWLPI 490
            ||:|:.||||||||||||..||:|||||:|:|||||:||.||:||.:.|.::||..|||||||||
Zfish   446 FASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVVVFGSIVLLMLWLPI 510

  Fly   491 RILQVVCPDFLPY--ALSGD---SAVNLQLLLLQIVLPGFFEQTQTRIWLKGLLRIWCTAVAWLL 550
            ||::.:.|.||||  .|..|   |.::|:|||||:|||...||..||.|||||:|.|.....:||
Zfish   511 RIIKHIFPSFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLL 575

  Fly   551 GIRSYLLPAPEPEPEIPAAGEEGVENAAGENENQEGEAADAAAQPPAPPPPPPPPVEPAPAPRNL 615
            .:.||||           ..:|..||.|.:..|...:.|...|.|              .....|
Zfish   576 DLHSYLL-----------GDQEDNENNANQQANNNNQQARNNAIP--------------VVGEGL 615

  Fly   616 AAAHQAIMQRDAPVGFQPYDKPSLFALRLCALLALMCLSIVCAAMLTLTVPVYIGRRLMLIWSSQ 680
            .||||||:|:..|||||||.:|..|.||:..|:..||::::.|:::.||:||:.||.||..|:
Zfish   616 HAAHQAILQQGGPVGFQPYHRPMKFPLRIVLLILFMCVTLLLASLVCLTLPVFTGRWLMSFWT-- 678

  Fly   681 PDEKAAGAAAAEGAGEVVENLDPIDPEGARKNERLLRSHELYTAELGGYLCWIVCRVVAAVVTLL 745
                  |:|                           :.||||||..|.|:||:..|.:..::..:
Zfish   679 ------GSA---------------------------KIHELYTAACGLYVCWLSIRAITVLLAWM 710

  Fly   746 PQGRAAIVDKIKHW----------------VRVALQYALPVLTLLGIFVLVPLLIGLLIELAVVI 794
            ||||..|:.||:.|                :...::..:..:.|.|:   :|||:|||.||.:|.
Zfish   711 PQGRRVILLKIQEWTLMLQDSSCLKNGVTCIAQIMKTLIVAVLLAGV---IPLLLGLLFELVIVA 772

  Fly   795 PLRVPLRKTPIHFLWEDWALGVLYCKIAIALTMMGPDWHLKRALDRAYMDGLRDFDLKFVMRDLA 859
            ||||||.:||:.:.|:|||||||:.||..|:|:|||.|.||..:::.|.:|:|:.||.|::|.||
Zfish   773 PLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHFIIRKLA 837

  Fly   860 VPVVTTIGLALAIPYVMAHMMFPIFLADAYAQHVVARLVYPVSFIVVGSICILLFQIDQLKKLYL 924
            .||:..:.|:|.||||:|..:.|:.......|::|.|.:||...:||..:.||.|||.|.|:||.
Zfish   838 APVIAVLLLSLCIPYVIAVGIVPLLGVTMEMQNLVQRRIYPFLLMVVFLMGILSFQIRQFKRLYE 902

  Fly   925 SIKVDKYLVGQRLVNYEHR 943
            .||.|||||||||||||.:
Zfish   903 HIKNDKYLVGQRLVNYERK 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1317	NP_001163328.1	RINGv	9..56	CDD:128983	30/46 (65%)
CG1317	NP_001163328.1	DotA_TraY	<737..913	CDD:275142	72/191 (38%)
march6	XP_005163506.1	RINGv	9..57	CDD:128983	31/47 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592679
Domainoid	1	1.000	818	1.000	Domainoid score	I69
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4301
Inparanoid	1	1.050	910	1.000	Inparanoid score	I360
OMA	1	1.010	-	-		QHG55388
OrthoDB	1	1.010	-	-		D170933at2759
OrthoFinder	1	1.000	-	-		FOG0003180
OrthoInspector	1	1.000	-	-		oto38824
orthoMCL	1	0.900	-	-		OOG6_102767
Panther	1	1.100	-	-	LDO	PTHR13145
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R328
SonicParanoid	1	1.000	-	-		X3077
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940