DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drpr and Megf10

DIOPT Version :9

Sequence 1:NP_001261276.1 Gene:drpr / 38218 FlyBaseID:FBgn0027594 Length:1042 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:1161 Identity:400/1161 - (34%)
Similarity:553/1161 - (47%) Gaps:154/1161 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTYRIK 68
            ||..|....:..|...:|:.||:|...|.|:|.|..:....|.:...|.|.....  :|:.:||.
Mouse    11 LICSLLCHWVGTASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRIS 75

  Fly    69 HRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDIN 131
            :|...:  .||:.:.:  ..||.|:..|...|||||::.|.|||||:|..|:|:.|:||..|...
Mouse    76 YRTAYRHGEKTMYRRK--SQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSA 138

  Fly   132 CPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKC 196
            |....:|.:||.:|.|.|.|:|.|.:|.|.||.||.|.||.|.|.:|.:|.:|.::|:|:||..|
Mouse   139 CDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203

  Fly   197 HHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKC 261
            .|::|||:|:||:||..|:..||.||||..|:|.|||||.|.|...||.|.|..||.|.||...|
Mouse   204 DHITGECRCSPGYTGAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268

  Fly   262 PVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCD 326
            |.|.:|..|.:.|:|:.|..|...||||.|.|||.||||.|||.:.:||..|:..|.|.|...|.
Mouse   269 PEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCY 333

  Fly   327 RANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTR 391
            ..:|||:|..|::|..|..|:|....||:.|::.|.|.:::|..|||.:|.|.|..|||...|..
Mouse   334 HVSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNE 398

  Fly   392 PCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAK 456
            .|:...||..|:..|:|:|||.|..|.|.|.||||::|..|...|..|.:|.:|:.||.|:|.|.
Mouse   399 TCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAV 463

  Fly   457 CEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERK 521
            |.|..|.|:|.|||..:.|...|....:|..|...|.|.|..|||..:|:||||.||.|.:||..
Mouse   464 CSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGAKCEFP 528

  Fly   522 CDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNS 586
            |..|.:|.:||::|.|  :::..|..|.|.|.|...|.||||::.|..|.:|.||...|.|.|.:
Mouse   529 CQDGTYGLNCAERCDC--SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591

  Fly   587 SCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTC 651
            ||.||.|.|.|:.|:.|..|...|.|||||..|.:.||:.:|.:..|.||||...|..|:.|..|
Mouse   592 SCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656

  Fly   652 EHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHH 716
            ...||:|.:|..|...|.|.:.|.||.:...|||.|||.||:|::.||...:|..|...|.|.:.
Mouse   657 NEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNG 721

  Fly   717 KVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCD 781
            ..|...||.|.|..||:|..|.:.||.||||:.|...|.|.:.....|.:..|.||:|:.|.:|:
Mouse   722 AFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCE 786

  Fly   782 ELIAS-------QRIADQSENS----------------------------------SRASVAL-- 803
            :...:       ::|.|...||                                  ||.|.||  
Mouse   787 QKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPA 851

  Fly   804 ------------TLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------HDTNP 844
                        .|||:.||   :.|:||.||.:....::.:..|.||            .:|.|
Mouse   852 DSYQIGAIAGIVVLVLVVLF---LLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLP 913

  Fly   845 PSWPPN---HNFDNPVYGMQAETRLLPN-NMRSKMN----------------NFDQRSTMSTDYG 889
            .|...|   |.|.||.|...::....|: |.|.:|.                |..:|.|:.    
Mouse   914 HSNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGTLV---- 974

  Fly   890 DDCN----ASGRVGSY-----SINYNHDLLTKNLNADRTNPIVYNESL----KEEHVYDEIKHKE 941
             ||.    |..:.|.|     :...:...:.|:|. |......||.|.    ..|:.|..|    
Mouse   975 -DCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLK-DLGKNSEYNSSTCSLSSSENPYATI---- 1033

  Fly   942 GYKDPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKP---------SNVK 997
              |||..:..|    ..|..:::...|:....|:....|....|.|..|.:|         ||..
Mouse  1034 --KDPPALLPK----SSECGYVEMKSPARRDSPYAEINNSTPANRNVYEVEPTVSVVQGVFSNSG 1092

  Fly   998 NMTV----------------LLNKPLPPTEPEPQHECFDNTNTNLDNVSTASPSSS 1037
            ::|.                ||  |:..:...|:.|....:|:...|.:::|.|||
Mouse  1093 HVTQDPYDLPKNSHIPCHYDLL--PVRDSSSSPKREDGGGSNSTSSNSTSSSSSSS 1146

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drprNP_001261276.1 EMI 27..92 CDD:284877 18/68 (26%)
EGF_CA 274..319 CDD:304395 23/44 (52%)
DSL <479..518 CDD:302925 17/38 (45%)
DSL <567..606 CDD:302925 17/38 (45%)
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 331/849 (39%)
EMI 32..99 CDD:284877 18/68 (26%)
EGF_CA 281..326 CDD:304395 23/44 (52%)
EGF_CA 542..587 CDD:304395 18/46 (39%)
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147 45/220 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147 12/56 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 89 1.000 Domainoid score I7842
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 789 1.000 Inparanoid score I512
Isobase 1 0.950 - 0 Normalized mean entropy S4145
OMA 1 1.010 - - QHG47996
OrthoDB 1 1.010 - - D34806at33208
OrthoFinder 1 1.000 - - FOG0001631
OrthoInspector 1 1.000 - - otm42950
orthoMCL 1 0.900 - - OOG6_102891
Panther 1 1.100 - - O PTHR24035
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5768
SonicParanoid 1 1.000 - - X1195
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.820

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