Protein Alignment drpr and Megf10

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_001001979.1
• Gene: Megf10 / 70417
• MGIID: 2685177
• Length: 1147
• Species: Mus musculus
• Alignment Length: 1161
• Identity: 400/1161 - (34%)
• Similarity: 553/1161 - (47%)
• Gaps: 154/1161 - (13%)

  Fly     6 LIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTYRIK 68
            ||..|....:..|...:|:.||:|...|.|:|.|..:....|.:...|.|.....  :|:.:||.
Mouse    11 LICSLLCHWVGTASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRIS 75

  Fly    69 HRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDIN 131
            :|...:  .||:.:.:  ..||.|:..|...|||||::.|.|||||:|..|:|:.|:||..|...
Mouse    76 YRTAYRHGEKTMYRRK--SQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSA 138

  Fly   132 CPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKC 196
            |....:|.:||.:|.|.|.|:|.|.:|.|.||.||.|.||.|.|.:|.:|.:|.::|:|:||..|
Mouse   139 CDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203

  Fly   197 HHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKC 261
            .|::|||:|:||:||..|:..||.||||..|:|.|||||.|.|...||.|.|..||.|.||...|
Mouse   204 DHITGECRCSPGYTGAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268

  Fly   262 PVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCD 326
            |.|.:|..|.:.|:|:.|..|...||||.|.|||.||||.|||.:.:||..|:..|.|.|...|.
Mouse   269 PEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCY 333

  Fly   327 RANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTR 391
            ..:|||:|..|::|..|..|:|....||:.|::.|.|.:::|..|||.:|.|.|..|||...|..
Mouse   334 HVSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNE 398

  Fly   392 PCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAK 456
            .|:...||..|:..|:|:|||.|..|.|.|.||||::|..|...|..|.:|.:|:.||.|:|.|.
Mouse   399 TCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAV 463

  Fly   457 CEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERK 521
            |.|..|.|:|.|||..:.|...|....:|..|...|.|.|..|||..:|:||||.||.|.:||..
Mouse   464 CSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGAKCEFP 528

  Fly   522 CDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNS 586
            |..|.:|.:||::|.|  :::..|..|.|.|.|...|.||||::.|..|.:|.||...|.|.|.:
Mouse   529 CQDGTYGLNCAERCDC--SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591

  Fly   587 SCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTC 651
            ||.||.|.|.|:.|:.|..|...|.|||||..|.:.||:.:|.:..|.||||...|..|:.|..|
Mouse   592 SCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656

  Fly   652 EHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHH 716
            ...||:|.:|..|...|.|.:.|.||.:...|||.|||.||:|::.||...:|..|...|.|.:.
Mouse   657 NEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNG 721

  Fly   717 KVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCD 781
            ..|...||.|.|..||:|..|.:.||.||||:.|...|.|.:.....|.:..|.||:|:.|.:|:
Mouse   722 AFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCE 786

  Fly   782 ELIAS-------QRIADQSENS----------------------------------SRASVAL-- 803
            :...:       ::|.|...||                                  ||.|.||
Mouse   787 QKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPA 851

  Fly   804 ------------TLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------HDTNP 844
                        .|||:.||   :.|:||.||.:....::.:..|.||            .:|.|
Mouse   852 DSYQIGAIAGIVVLVLVVLF---LLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLP 913

  Fly   845 PSWPPN---HNFDNPVYGMQAETRLLPN-NMRSKMN----------------NFDQRSTMSTDYG 889
            .|...|   |.|.||.|...::....|: |.|.:|.                |..:|.|:.
Mouse   914 HSNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGTLV---- 974

  Fly   890 DDCN----ASGRVGSY-----SINYNHDLLTKNLNADRTNPIVYNESL----KEEHVYDEIKHKE 941
             ||.    |..:.|.|     :...:...:.|:|. |......||.|.    ..|:.|..|
Mouse   975 -DCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLK-DLGKNSEYNSSTCSLSSSENPYATI---- 1033

  Fly   942 GYKDPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKP---------SNVK 997
              |||..:..|    ..|..:::...|:....|:....|....|.|..|.:|         ||..
Mouse  1034 --KDPPALLPK----SSECGYVEMKSPARRDSPYAEINNSTPANRNVYEVEPTVSVVQGVFSNSG 1092

  Fly   998 NMTV----------------LLNKPLPPTEPEPQHECFDNTNTNLDNVSTASPSSS 1037
            ::|.                ||  |:..:...|:.|....:|:...|.:::|.|||
Mouse  1093 HVTQDPYDLPKNSHIPCHYDLL--PVRDSSSSPKREDGGGSNSTSSNSTSSSSSSS 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	19/69 (28%)
		EGF_CA	274..319	CDD:473889	23/44 (52%)
		gliding_CglD	<451..579	CDD:468178	53/127 (42%)
		DSL	567..609	CDD:473190	18/41 (44%)
Megf10	NP_001001979.1	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7	1..857		331/849 (39%)
		EMI	31..100	CDD:462204	19/70 (27%)
		EGF_Lam	281..318	CDD:214543	20/36 (56%)
		EGF_CA	542..587	CDD:473889	18/46 (39%)
		Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7	945..1147		45/220 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1147		12/56 (21%)