Protein Alignment: drpr and Megf10

• Sequence 1: NP_001261276.1
• Gene: drpr
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_001001979.1
• Gene: Megf10
• MGIID: 2685177
• Length: 1147
• Species: Mus musculus
• Alignment Length: 1161
• Identity: 400/1162 (34%)
• Similarity: 553/1162 (48%)
• Gaps: 154/1162 (13%)

  Fly     6 LIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWCVTFPP--RCSTYRIK 68
            ||..|....:..|...:|:.||:|...|.|:|.|..:....|.:...|.|.....  :|:.:||.
Mouse    11 LICSLLCHWVGTASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRIS 75

  Fly    69 HRVVNK--TKTIAKNRIVRDCCDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYGGPACDIN 131
            :|...:  .||:.:.:  ..||.|:..|...|||||::.|.|||||:|..|:|:.|:||..|...
Mouse    76 YRTAYRHGEKTMYRRK--SQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSA 138

  Fly   132 CPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCENGGKC 196
            |....:|.:||.:|.|.|.|:|.|.:|.|.||.||.|.||.|.|.:|.:|.:|.::|:|:||..|
Mouse   139 CDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATC 203

  Fly   197 HHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKC 261
            .|::|||:|:||:||..|:..||.||||..|:|.|||||.|.|...||.|.|..||.|.||...|
Mouse   204 DHITGECRCSPGYTGAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPC 268

  Fly   262 PVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCD 326
            |.|.:|..|.:.|:|:.|..|...||||.|.|||.||||.|||.:.:||..|:..|.|.|...|.
Mouse   269 PEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCY 333

  Fly   327 RANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTR 391
            ..:|||:|..|::|..|..|:|....||:.|::.|.|.:::|..|||.:|.|.|..|||...|..
Mouse   334 HVSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNE 398

  Fly   392 PCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAK 456
            .|:...||..|:..|:|:|||.|..|.|.|.||||::|..|...|..|.:|.:|:.||.|:|.|.
Mouse   399 TCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAV 463

  Fly   457 CEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERK 521
            |.|..|.|:|.|||..:.|...|....:|..|...|.|.|..|||..:|:||||.||.|.:||..
Mouse   464 CSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGAKCEFP 528

  Fly   522 CDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNS 586
            |..|.:|.:||::|.|  :::..|..|.|.|.|...|.||||::.|..|.:|.||...|.|.|.:
Mouse   529 CQDGTYGLNCAERCDC--SHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGA 591

  Fly   587 SCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTC 651
            ||.||.|.|.|:.|:.|..|...|.|||||..|.:.||:.:|.:..|.||||...|..|:.|..|
Mouse   592 SCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALC 656

  Fly   652 EHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVHH 716
            ...||:|.:|..|...|.|.:.|.||.:...|||.|||.||:|::.||...:|..|...|.|.:.
Mouse   657 NEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNG 721

  Fly   717 KVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHGCVCRSGYTGDNCD 781
            ..|...||.|.|..||:|..|.:.||.||||:.|...|.|.:.....|.:..|.||:|:.|.:|:
Mouse   722 AFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCE 786

  Fly   782 ELIAS-------QRIADQSENS----------------------------------SRASVAL-- 803
            :...:       ::|.|...||                                  ||.|.||
Mouse   787 QKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPA 851

  Fly   804 ------------TLVLMTLFACIIFAVFIYYRRRVSNLKTEIAHVHYT------------HDTNP 844
                        .|||:.||   :.|:||.||.:....::.:..|.||            .:|.|
Mouse   852 DSYQIGAIAGIVVLVLVVLF---LLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLP 913

  Fly   845 PSWPPN---HNFDNPVYGMQAETRLLPN-NMRSKMN----------------NFDQRSTMSTDYG 889
            .|...|   |.|.||.|...::....|: |.|.:|.                |..:|.|:.
Mouse   914 HSNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGTLV---- 974

  Fly   890 DDCN----ASGRVGSY-----SINYNHDLLTKNLNADRTNPIVYNESL----KEEHVYDEIKHKE 941
             ||.    |..:.|.|     :...:...:.|:|. |......||.|.    ..|:.|..|
Mouse   975 -DCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLK-DLGKNSEYNSSTCSLSSSENPYATI---- 1033

  Fly   942 GYKDPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKP---------SNVK 997
              |||..:..|    ..|..:::...|:....|:....|....|.|..|.:|         ||..
Mouse  1034 --KDPPALLPK----SSECGYVEMKSPARRDSPYAEINNSTPANRNVYEVEPTVSVVQGVFSNSG 1092

  Fly   998 NMTV----------------LLNKPLPPTEPEPQHECFDNTNTNLDNVSTASPSSS 1037
            ::|.                ||  |:..:...|:.|....:|:...|.:::|.|||
Mouse  1093 HVTQDPYDLPKNSHIPCHYDLL--PVRDSSSSPKREDGGGSNSTSSNSTSSSSSSS 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	18/69 (26%)
		EGF_CA	274..319	CDD:304395	23/45 (51%)
		DSL	<479..518	CDD:302925	17/39 (44%)
		DSL	<567..606	CDD:302925	17/39 (44%)
Megf10	NP_001001979.1	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. {ECO:0000250|UniProtKB:Q96KG7}	1..857		331/850 (39%)
		EMI	32..99	CDD:284877	18/69 (26%)
		EGF_CA	281..326	CDD:304395	23/45 (51%)
		EGF_CA	542..587	CDD:304395	18/47 (38%)
		Necessary for formation of large intracellular vacuoles. {ECO:0000250|UniProtKB:Q96KG7}	945..1147		45/221 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG1218
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I506
Isobase	1	0.950		0	Normalized mean entropy	S4145
OMA	1	1.010
OrthoDB	1	1.010				D34806at33208
OrthoFinder	1	1.000				FOG0001055
OrthoInspector	1	1.000				T617058
orthoMCL	1	0.900				OOG5_128415
Panther	1	1.100			LDO	PTHR24035
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R5768
TreeFam	1	0.960
	12	11.910