DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and flt3

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_001921760.3	Gene:	flt3 / 566708	ZFINID:	ZDB-GENE-050114-4	Length:	956	Species:	Danio rerio

Alignment Length:	566	Identity:	103/566 - (18%)
Similarity:	160/566 - (28%)	Gaps:	207/566 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAQLVLAQADLK----------DLDGPNI-CKRREL-------YNVDVV---YTELQSFQERGST 53
            |..|||..:.||          |.||..: |...|.       ..:||.   ..|:.|..|:.|:
Zfish     9 LVLLVLHWSSLKDGLTEAHPRCDTDGSTVRCTLEETDLMSSDPIKLDVTEGQVVEIYSACEQNSS 73

  Fly    54 ---WCVTFPPRCSTYRI----------KHRVVNKTKTIAKNRIVRDCCDGYIASAGECVPHCSEP 105
               .|:.:....|:..:          |:.|:...||:...|..:         ....||.....
Zfish    74 NERKCLCYQRTNSSIHLLQCIEKLGNEKYSVICGNKTVTAVRATQ---------RRPSVPVLKAI 129

  Fly   106 CQHGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGAR 170
            .:.|.....:......||..|..      .|||.:                   .:.|:|.|.:.
Zfish   130 LKAGSTNLAQLVCTSEGYPKPTL------RWYGNS-------------------DDAAEGMTSSA 169

  Fly   171 CAD----ICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQ-- 229
            |..    |....:...|.::||                             |.....|.:|.:
Zfish   170 CKTESTLISYYSYLSKNPNQKC-----------------------------CASNALGEECTEVY 205

  Fly   230 --DCPCQNDGKCQP----ETGACMC---------NPG--------------------WTGDV--- 256
              |...:|..|.|.    ::|..:.         |||                    ||..:
Zfish   206 HYDLNEKNKQKSQNIIYLKSGQSLLLRAARKHFKNPGIKWHFNNTVIKGITSLQFYDWTEHLFIE 270

  Fly   257 CANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCDCAN 321
            ..|....|.|  .|....|..:....|              .:.|:..|::....|.:      |
Zfish   271 SVNMAHSGLY--LCTSDTETPRNCSTH--------------VKVFEHDQIDILHLNEN------N 313

  Fly   322 DAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHT-DLCHPETGNCQCSIGWS 385
            ..:.....|.|..:..::..|........|:..:.|:.|.:.:...| .||:.|.|..|..:.
Zfish   314 SILAKNKTGFCFQSQVFSYPKARCYWITPNQTQIQCDETSQSNFTSTFKLCNTEPGQYQMKLE-- 376

  Fly   386 SAQCTRPCTFLRYGPNC-----ELTCNCKNGAKCSPVNGTCLCAPGWRGPTCE-ESCEPGTFGQD 444
                |:..:.:|....|     ::|.. ||.:                ..||| ||..|.|....
Zfish   377 ----TQEYSVMRNVSLCISDIPKITIR-KNSS----------------FTTCETESPLPVTVSWK 420

  Fly   445 CALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAK 490
                 .|.:.|||:||        .||.|..|:| :.....|.|.|
Zfish   421 -----TCPSLAKCDPE--------DWKEIAADQP-EFTDSDQFCQK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	15/88 (17%)
		EGF_CA	274..319	CDD:304395	5/44 (11%)
		DSL	<479..518	CDD:302925	3/12 (25%)
		DSL	<567..606	CDD:302925
flt3	XP_001921760.3	IGc2	225..283	CDD:197706	9/59 (15%)
flt3	XP_001921760.3	PKc_like	522..907	CDD:328722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900