DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and Y64G10A.7

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001255802.1	Gene:	Y64G10A.7 / 178377	WormBaseID:	WBGene00013416	Length:	1714	Species:	Caenorhabditis elegans

Alignment Length:	887	Identity:	306/887 - (34%)
Similarity:	402/887 - (45%)	Gaps:	199/887 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CCDGYIASA-----------GECVP--------------HCSEPCQH---GR-CISP-------- 114
            |.||:..|.           |.|.|              .|.:||.|   |: |..|
Worm   727 CPDGFYGSQCNLKCRMDCPNGRCDPVFGYCTCPDGLYGQSCEKPCPHFTFGKNCRFPCKCARENS 791

  Fly   115 -------EKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDC--ECAKGYTGAR 170
                   .||:|..||.|..|...|.||.:|..|:|:|.|.....|:|.:|||  :|..||.|..
Worm   792 EGCDEITGKCRCKPGYYGHHCKRMCSPGLFGAGCAMKCSCPAGIRCDPVTGDCTKKCPAGYQGNL 856

  Fly   171 CADICPEGFFGANCSEKCRCENGGK------CHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQ 229
            |...||.|:||.:|.:||.|.:...      ||||:|.|.|.||.||||||..|....:|..|..
Worm   857 CDQPCPAGYFGYDCEQKCSCADVASPHKSKVCHHVTGTCTCLPGKTGPLCDQSCAPNTYGPNCAH 921

  Fly   230 DCPCQNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPG 294
            .|.|.|..||....|:|.|.||:.|..|:..||.|.:|..|.:.|:|..||.|....|.|||.||
Worm   922 TCSCVNGAKCDESDGSCHCTPGFYGATCSEVCPTGRFGIDCMQLCKCQNGAICDTSNGSCECAPG 986

  Fly   295 YRGERCFDECQLNTYGFNCSMTCDCA--------------------------------------- 320
            :.|::|...|...|:|.:||..||||
Worm   987 WSGKKCDKACAPGTFGKDCSKKCDCADGMHCDPSDGECICPPGKKGHKCDETCDSGLFGAGCKGI 1051

  Fly   321 ----NDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEH-TDL-------CHP 373
                |.|.||...|:|.|.|||.|.|| :|.|...::|..||..|:|...: |.:       |..
Worm  1052 CSCQNGATCDSVTGSCECRPGWRGKKC-DRPCPDGRFGEGCNAICDCTTTNDTSMYNPFVARCDH 1115

  Fly   374 ETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPV--------------------- 417
            .||.|:|..||:...|...|...|:|..|..:|.|.|||.|..|
Worm  1116 VTGECRCPAGWTGPDCQTSCPLGRHGEGCRHSCQCSNGASCDRVTGFCDCPSGFMGKNCESECPE 1180

  Fly   418 ----------------------NGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPE 460
                                  ||.|.|..||.||:||..|..|.||::||.||:|:|||.|:.:
Worm  1181 GLWGSNCMKHCLCMHGGECNKENGDCECIDGWTGPSCEFLCPFGQFGRNCAQRCNCKNGASCDRK 1245

  Fly   461 TGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTG 525
            ||:|.|..||....|::.|...|:|..|.:.|:|.|.|.|:|.:|.|:|..||.|::|.|.|..|
Worm  1246 TGRCECLPGWSGEHCEKSCVSGHYGAKCEETCECENGALCDPISGHCSCQPGWRGKKCNRPCLKG 1310

  Fly   526 KFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDP 590
            .||..|:|.|:|  .||.:||..:|||.|.:.:.|..|...|..|.:||:|.:.|.|..||.||.
Worm  1311 YFGRHCSQSCRC--ANSKSCDHISGRCQCPKGYAGHSCTELCPDGTFGESCSQKCDCGENSMCDA 1373

  Fly   591 DSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPC 655
            .||.|.|..|.:|:||...|..|.:|.:|.:.|.  ......||..||..:|..||||..||..|
Worm  1374 ISGKCFCKPGHSGSDCKSGCVQGRFGPDCNQLCS--CENGGVCDSSTGSCVCPPGYIGTKCEIAC 1436

  Fly   656 PAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQRCRCVH-HKVC 719
            .:..:||.|:..||||:||.|:.:||||:||||:||..||:.||...:|.||.::|||.: |  |
Worm  1437 QSDRFGPTCEKICNCENGGTCDRLTGQCRCLPGFTGMTCNQVCPEGRFGAGCKEKCRCANGH--C 1499

  Fly   720 RKADGMCICETGWSG-------------------------TRCDEV------------------C 741
            ..:.|.|.|..|::|                         .|||.|                  |
Worm  1500 NASSGECKCNLGFTGPSCEQSCPSGKYGLNCTLDCECYGQARCDPVQGCCDCPPGRYGSRCQFSC 1564

  Fly   742 PEGFYGEHCMNTCACPSANFQCHAAHG-CVCRSGYTGDNCDE 782
            |.||||.:|..:|:|.: ...|..|.| |:|.:|:.||.|::
Worm  1565 PNGFYGWYCSQSCSCQN-GAHCDGADGRCLCPAGFQGDKCEQ 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	3/4 (75%)
		EGF_CA	274..319	CDD:304395	19/44 (43%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	17/38 (45%)
Y64G10A.7	NP_001255802.1	EMI	35..105	CDD:284877
		FXa_inhibition	159..194	CDD:291342
		FXa_inhibition	200..235	CDD:291342
		FXa_inhibition	241..278	CDD:291342
		vWFA	<319..358	CDD:294047
		FXa_inhibition	366..402	CDD:291342
		vWFA	<460..502	CDD:294047
		FXa_inhibition	509..544	CDD:291342
		FXa_inhibition	550..585	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I4493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910