Protein Alignment drpr and ced-1

DIOPT Version :9

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_740922.1
• Gene: ced-1 / 173064
• WormBaseID: WBGene00000415
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1151
• Identity: 353/1151 - (30%)
• Similarity: 496/1151 - (43%)
• Gaps: 219/1151 - (19%)

  Fly     4 VILIACLA--QLV---------------LAQADLKDLDGPNICKRR------ELYNV--DVVYTE 43
            :||:..||  |:|               |.|....:..|.::|..:      ||..|  .|||.:
 Worm     3 LILLVLLATWQVVVDTRAPTFPDKLTQQLQQQGTTEPQGDHVCTVKTIVDDYELKKVIHTVVYND 67

  Fly    44 -------LQSFQERGSTWCVTFPPRCSTYRIKHRVVNKTKTIAKNRIVRDCCDGYIASAGE-CVP 100
                   |..||             |:..:...:...:.:.:.|.:.|:.|||||..:... |:|
 Worm    68 TEQCLNPLTGFQ-------------CTVEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLP 119

  Fly   101 HCSEPCQHGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKG 165
            .|:.||:.|:||.|.||:||.||||..|..:|..|.:|..||..|||.|.|.|:|..|.|.|..|
 Worm   120 DCNPPCKKGKCIEPGKCECDPGYGGKYCASSCSVGTWGLGCSKSCDCENGANCDPELGTCICTSG 184

  Fly   166 YTGARCADICPEGFFGANCSEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQD 230
            :.|.||...||:..:|.||.:.|.|:|||||:. .|:|.|:.|:.|..|..:|.:||.||:|:.:
 Worm   185 FQGERCEKPCPDNKWGPNCVKSCPCQNGGKCNK-EGKCVCSDGWGGEFCLNKCEEGKFGAECKFE 248

  Fly   231 CPCQNDGKCQPETGACMCNPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGY 295
            |.|||...|....|.|:|..|:.|.:|.|:|.||.:|.||.:.|:|.....|...:|:|:| .|:
 Worm   249 CNCQNGATCDNTNGKCICKSGYHGALCENECSVGFFGSGCTQKCDCLNNQNCDSSSGECKC-IGW 312

  Fly   296 RGERCFDECQLNTYGFNCSMTCDCA------NDAMCDRANGTCICNPGWTGAKCAERICEANKYG 354
            .|:.|...|....:|..|...|.|.      ::|.||...|.|.|..|:.|.||.||.|:|.:||
 Worm   313 TGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNASCDAKTGQCQCESGYKGPKCDERKCDAEQYG 377

  Fly   355 LDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCE--LTCNCKNGAKCSPV 417
            .||::||.|..|:|.:|.|.||.|:|..|:....|...|:...||||||  ..|:..:.::|:|.
 Worm   378 ADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWNHASECNPE 442

  Fly   418 NGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDC-QNGAKCEPETGQCLCTAGWKNIKCDRPCDL 481
            .|:|:|.||..|..|.|.|....:|.:||.:|.| |.|..|:...|:|.|..||...:|:..|..
 Worm   443 TGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQCNQRGVGCDGADGKCQCDRGWTGHRCEHHCPA 507

  Fly   482 NHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACD 546
            :.||.:|.|.|.|.....|:|..|.|||.||..|..|:..|..|.:|..|...|:| .|..  ||
 Worm   508 DTFGANCEKRCKCPKGIGCDPITGECTCPAGLQGANCDIGCPEGSYGPGCKLHCKC-VNGK--CD 569

  Fly   547 ATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADC----- 606
            ...|.|.|:..:.|..|.|.|..|.|||:|:..|.| :::||...:|.|:|..|..|..|
 Worm   570 KETGECTCQPGFFGSDCSTTCSKGKYGESCELSCPC-SDASCSKQTGKCLCPLGTKGVSCDQKCD 633

  Fly   607 -------------------AEP-------CPPGFYGMECKERCPEILHGN-----------KSCD 634
                               .:|       ||||..|:.|:..||...:|:           ..||
 Worm   634 PNTFGFLCQETVTPSPCASTDPKNGVCLSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCD 698

  Fly   635 HITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKC-NCEHGGECNHVTGQCQCLPGWTGSNCNESC 698
            ..|||.:|..||.|.||...||.|.||.||.|.| .|..|..|:|:.|.|.|..|..|:.|...|
 Worm   699 PTTGECICEPGYHGKTCSEKCPDGKYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPC 763

  Fly   699 PTDTYGQGCAQRCRCV-HHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACP-SANF 761
            ....:|.||.|.|||. .:|.|....|.|.|..|:.|.|||:.|.:|:||..|:..|.|. :|..
 Worm   764 SAGFWGNGCRQVCRCTSEYKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATS 828

  Fly   762 QCHAAHG-CVCRSGYTGD----------------------------NCDELIASQRIADQSE--- 794
            .|:...| |.|..|:||:                            .||..|....: ||..
 Worm   829 SCNRVSGACHCHPGFTGEFCHALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHV-DQMSCGK 892

  Fly   795 --------NSSRASVALTLVLMTLFACI---IFAVFIYYRRRVSNLKTEIAHVHYTHDTNPPSWP 848
                    |.:..|..||...:.|...:   :..:.::||.:....|             .|..|
 Worm   893 AKQEFEALNGAGRSTGLTWFFVLLIVALCGGLGLIALFYRNKYQKEK-------------DPDMP 944

  Fly   849 -------PNHN----FDNPVYGMQA---------------------------ETRLLPNNMRSKM 875
                   ||::    |.||:|..|:                           |...|.|   .|:
 Worm   945 TVSFHKAPNNDEGREFQNPLYSRQSVFPDSDAFSSENNGNHQGGPPNGLLTLEEEELEN---KKI 1006

  Fly   876 NNFDQRSTMSTDYG--DDCNASGRVGSYSINYNHDLLTKNLNADRTNPIVYNESLKEEHVYDEIK 938
            :........:.||.  |:....|...|.|.:.:.    :.||:...:    ...|.|||  ||.:
 Worm  1007 HGRSAAGRGNNDYASLDEVAGEGSSSSASASASR----RGLNSSEQS----RRPLLEEH--DEEE 1061

  Fly   939 HKEGYKD---PVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRMND 981
            ..|.:::   |....:.....|:.|..:....|.|....:..|..|
 Worm  1062 FDEPHENSISPAHAVTTSNHNENPYADISSPDPVTQNSANKKRAQD 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	17/79 (22%)
		EGF_CA	274..319	CDD:304395	13/44 (30%)
		DSL	<479..518	CDD:302925	16/38 (42%)
		DSL	<567..606	CDD:302925	15/38 (39%)
ced-1	NP_740922.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13031
Inparanoid	1	1.050	641	1.000	Inparanoid score	I441
Isobase	1	0.950	-	0	Normalized mean entropy	S4145
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	1	1.000	-	-		FOG0001631
OrthoInspector	1	1.000	-	-		oto18762
orthoMCL	1	0.900	-	-		OOG6_102891
Panther	1	1.100	-	-	LDO	PTHR24035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5768
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.890