Protein Alignment RabX5 and RAB6A

DIOPT Version :10

• Sequence 1: NP_647644.2
• Gene: RabX5 / 38209
• FlyBaseID: FBgn0035255
• Length: 277
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 244
• Identity: 79/244 - (32%)
• Similarity: 125/244 - (51%)
• Gaps: 42/244 - (17%)

  Fly    40 LSKERDFGAQVRYYLEAPRKPKFRPCKVIFVGDCSVGKTAIVNRFCYDKFQSNYKATIGVDFELE 104
            :|...|||..:|         ||   |::|:|:.|||||:::.||.||.|.:.|:||||:||..:
Human     1 MSTGGDFGNPLR---------KF---KLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSK 53

  Fly   105 NFSILGHNYSLEMWDTAGQERFRCIAGAYYRNASVIVVTYDMSKKDSLESAKKWLNSALNYNASK 169
            ...:......|::||||||||||.:..:|.|:::..||.||::..:|.:...||::.......|.
Human    54 TMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSD 118

  Fly   170 RPLVFLVGTKADLLSKEEFVRMERLAGLAAAELQAEYWSVSARSGFKVTELFQRIAAL-----AF 229
             .::.|||.|.||..|.: |.:|. ....|.||...:...||::|:.|.:||:|:||.     :.
Human   119 -VIIMLVGNKTDLADKRQ-VSIEE-GERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMEST 180

  Fly   230 EEAVMQEIRSIK-NKPQEQATQASVKSQTFDLRNFFGSRLSQQKSGCTC 277
            ::...:::..|| .|||||..                     .:.||:|
Human   181 QDRSREDMIDIKLEKPQEQPV---------------------SEGGCSC 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RabX5	NP_647644.2	P-loop containing Nucleoside Triphosphate Hydrolases	66..230	CDD:476819	62/168 (37%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	63/165 (38%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		10/17 (59%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		10/18 (56%)