Protein Alignment Srrm234 and Srrm2

DIOPT Version :10

• Sequence 1: NP_001097475.2
• Gene: Srrm234 / 38206
• FlyBaseID: FBgn0035253
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_001355616.1
• Gene: Srrm2 / 75956
• MGIID: 1923206
• Length: 2703
• Species: Mus musculus
• Alignment Length: 2039
• Identity: 461/2039 - (22%)
• Similarity: 703/2039 - (34%)
• Gaps: 736/2039 - (36%)

  Fly     1 MYNGIGLTTPRGSGTNGHVQRNWACVRPGKKDK-DYRAEDDTKKLDAQLNRPPNKEILDHDRKRK 64
            |||||||.|||||||||:||||.:.||..:.:: ||:.|::.:.|:|.|.:.||.:||||:|||:
Mouse     1 MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRHLEAALVKRPNPDILDHERKRR 65

  Fly    65 IEVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTA 129
            :|::|||||:::|:||...::|:.:|.:||..|:.:.....||:|
Mouse    66 VELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGAKEE-------------------- 110

  Fly   130 TASAATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTGE 194
                                                              |||
Mouse   111 --------------------------------------------------TPG------------ 113

  Fly   195 PASSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKT 259
                                                                             
Mouse   114 ----------------------------------------------------------------- 113

  Fly   260 RRPAVSKRTHPDCACACQQKDPEPALEPAHRTAEHSIQKELPSSQMKINIDGSVLLELLKYSSSS 324
            :||.|:
Mouse   114 QRPVVT----------------------------------------------------------- 119

  Fly   325 LLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSVAL 389
                             :|||:||..::||.|||.||.||:.:|:|||||..|:|:|  ||.:|
Mouse   120 -----------------ETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRARE--AKQIA- 164

  Fly   390 QKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKKKR 454
                                   .|..|.|:|||..|..|                 |.|.|:|:
Mouse   165 -----------------------PEPPKPYSLVRETSSSR-----------------SPTPKQKK 189

  Fly   455 KKR-----ARESSASP--ERKKKKKSKKHKKESKSKKKRSR-------------KRKHSES---- 495
            ||:     .|..|:||  ||||..|.|||:.||:|||::.|             |||.|.|
Mouse   190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPA 254

  Fly   496 ------GRDSDRDSDEEDDSSEEERRE---------------------------------SKNVR 521
                  .|.:..||....|:|....|.                                 :.|::
Mouse   255 PKSRRAHRSTSADSASSSDTSRSRSRSAAAKIHTTALTGQSPPLASGHQGEGDAPSVEPGATNIQ 319

  Fly   522 KKA-------KKDKKKRDKKLKKKSRARASSS----------------------DSER------- 550
            :.:       :......||..|:||..|.|.|                      ||.|
Mouse   320 QPSSPAPSTKQSSSPYEDKDKKEKSAVRPSPSPERSSTGPELPAPTPLLVEQHVDSPRPLAAIPS 384

  Fly   551 TNSPSRKENKSDRSRGAKASKSDEKAPQQENVMRSRSRER-----KDTRSSRPLEASIDSRQRKP 610
            :..|....:::..:||....||.||.||      |.|.|.     :.|:.||...:|.:|.:..|
Mouse   385 SQEPVNPSSEASPTRGCSPPKSPEKPPQ------STSSESCPPSPQPTKGSRHASSSPESLKPTP 443

  Fly   611 ---RERSAATPPRKEPERHRERSKDRQRS-KEKHRS-RDRLRSRERQRSRER---QRSRERQRSK 667
               ..|..::.|..:...|....:|:..| ...||: |.|..:.:|.|||.|   :|...|.||.
Mouse   444 APGSRREISSSPTSKNRSHGRAKRDKSHSHTPSHRAGRSRSPATKRGRSRSRTPTKRGHSRSRSP 508

  Fly   668 ERQRSKERQRSIERQRSKERQRSKERQR---SRSKDALRCKEKPQCNEKERSRERRRSKSKDRQ- 728
            :.:||:..||..:.:..:.|.||:..||   |||::..|         :.|||..||.:|..|.
Mouse   509 QWRRSRSAQRWGKSRSPQRRGRSRSPQRPGWSRSRNTQR---------RGRSRSARRGRSHSRSP 564

  Fly   729 ----RSKEK---HRPKDEQQSVDKRRDRSTDRSKENQRSNE-----RQRSKERQRSKERERSKDR 781
                ||:.:   .|.:...::..:||.||...::...||..     |.||:...|.:.|.||..|
Mouse   565 ATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVR 629

  Fly   782 QRSRERRRSKEGQLSKDRQGLKERQRSNERK-----RSKERQPSKEKQRSRE-------RQRSRE 834
            :|||.|.:::....|:.|...:...||..|.     ||:.|.|::...|||.       |.|||.
Mouse   630 RRSRSRSQARRSGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRSARSRSRTPARRGRSRSRT 694

  Fly   835 PLQSKDRQRSKERQ-RSRERPAKEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRNAR 898
            |.:.:.|.||..|: ||..|..:....:.|..||.:|||..:| ||.:|:|.:.|.....||.:|
Mouse   695 PARRRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR-RSRSNSSPEMKKSHVSSRRSR 758

  Fly   899 -FKSP----------------------------AHSPEAPPKKSVPTP-----AFNPFKAAEDTV 929
             ..||                            :.|..:|||:...||     :.:|....:...
Mouse   759 SLSSPRSKAKSLRRSLSGSSPCPKQKSQTPTRRSRSGSSPPKQKSKTPPRQSRSNSPQPKVKSGT 823

  Fly   930 NDILGTKSVMVALEQTKRQRAASSSSSDSDSSGSSSTSSRTP--------SPK----PTPRKQKK 982
            ....|:.:.|.|.|.|    |.....|.|:||......||||        ||:    ..||:...
Mouse   824 PPRPGSVTNMQADECT----ATPQRQSHSESSPDGEVKSRTPSRQSCSGSSPRVKSSTPPRQSPS 884

  Fly   983 RSKTPELKEVKKEISPRKESRVSVKREQSNSPQKSKSKSKVDESSPKRTSR-------------- 1033
            ||.:|:.| ||..||||..|..|     |:||    |.|:|...:|:|.||
Mouse   885 RSSSPQPK-VKTVISPRGRSHSS-----SSSP----SPSRVTSRTPQRKSRSISPCPKVDSRLRH 939

  Fly  1034 -RSRSISSE--------LRYS-------------PAERH--------PERYHDIVQDKK------ 1062
             ||||.|.:        ||:|             |.:::        |::..|......
Mouse   940 SRSRSSSPDSKMELGTPLRHSGSTSPYLKSMLQTPPDQNLSGSKSPCPQKSRDSPTGSSGSFHLC 1004

  Fly  1063 ---RPSKVREAHSTKPAPVVRLRAQSDDGSDA------ETGVDGAALEEFQQSRRE--------- 1109
               .||.:....|...|..|:.:..:....|.      :|.|:...|:...|:..:
Mouse  1005 PGVTPSSIVPGESCFSASFVQQKGHTQTWPDTSSPEVMQTQVESPLLQSKSQTSPKGSLSRSSSP 1069

  Fly  1110 ----------REEQQELRMLEQLKSGIA-----------------------------AKAKQKIK 1135
                      ::::.|:....:||||::                             ::.|:::.
Mouse  1070 VTELTARSPVKQDKSEISTDPKLKSGMSPEQSKTKPDSSIYPLVDSKSFLVQSRLEPSELKERLG 1134

  Fly  1136 IMEKD------------PAKEGSEVSGSDQVTATKRNSLSEFLVA------NNVTALINTLTTTT 1182
            ::::|            |.::..|  .|..:..|.|..|.|...|      .:..:|:...:...
Mouse  1135 LIQEDVASSCIPRDKFSPTQDRPE--SSTVLKVTPRVLLKERSGAGSPPGKRDQKSLLPNSSQDE 1197

  Fly  1183 VTLTTTPPPPLAVVVP--LEQRQEQPQ---QRDPDRELSVPVEDTVKKRDTSTPPICKTPQVTA- 1241
            :........||:.|:|  ..:.:|.|.   :..|:.|....|...:.:..:......:||.|.:
Mouse  1198 LMEVEKSEQPLSQVLPSLSPEHKEMPGSNIESSPEVEERPAVLSALDQSQSQPSKAAETPAVASC 1262

  Fly  1242 -NGDAKSPTLVHKNHVHHNRPPPQHMHHHSQQQQHHQHPPGKRIFHNRTLNN--NPNSRHSTNNP 1303
             :|...||.  ||...|   .||:.....|..:..:..|..:       :|.  :|..:...|..
Mouse  1263 WSGPQVSPE--HKELSH---SPPRENSFESSLEFKNSGPVSE-------VNTGFSPEVKEELNGS 1315

  Fly  1304 HACGGGGVPHSNSNSSNSGGNNNNAAMLPFLAGTPGTYNRTTNRLNHGPLLTATHYNICKNHQHS 1368
            ........|..:....:.....:::.:.|.:....|.:   :::....|:|...........:.|
Mouse  1316 FLNQTEADPSVDMKEQSRSSRRSSSELSPEVVEKVGLF---SSQKVSSPVLETVQQRTPSRERSS 1377

  Fly  1369 LQQQQAHHLARGLVYNSALFGHGQRHPGLLSLTGAGVGM-SGPGAPLLGHPSHVRGGGGPISFNA 1432
               ..:..|..||          .|.|...|.:|:..|: .|.|.|    ..|...|..|...:.
Mouse  1378 ---SASPELKDGL----------PRTPSRRSRSGSSPGLRDGSGTP----SRHSLSGSSPGMKDT 1425

  Fly  1433 AAAAAAVAANSISYLHHHHQHQQKPKIVIKPFKIHDPQPLVAALADSSLVDAIVSKVSTATV--- 1494
            ....:...:...|        ..:||.:.:..:.....|......:.|:........|.::|
Mouse  1426 PQTPSRGRSECDS--------SPEPKALPQTPRARSHSPSSPERNNKSVTPQRERSGSESSVEQK 1482

  Fly  1495 -AAAESAARRSRS--------------RERR-------SRSKRRTSTSHHRHDSSS---ESRSRY 1534
             .|..|..:||||              :||.       |:.|.||......|..||   :|:||:
Mouse  1483 NLARTSPGQRSRSGSSQELDGKPSASPQERSESDSSPDSKPKTRTPLRQRSHSGSSPEVDSKSRH 1547

  Fly  1535 SSSSSRSGS-----------HSSRSGSHSS-------RTSCSTNSSSGSSSSGSG---SGSSQSG 1578
            |...|||||           ..::||:.||       ..:...:|.|||||...|   .|||.|.
Mouse  1548 SPRLSRSGSSPEMKDKPRVLQRAQSGTDSSPEHKIPAPRALPRHSRSGSSSKERGPSPEGSSSSE 1612

  Fly  1579 SRSPSIPR----RRGSPSFLD---------RRRITSARKRPIPYHHKANAEGEVEDASSCCSSCF 1630
            |.....|:    ||||.|.::         |||  |:|..| ....||........||
Mouse  1613 SSPEHAPKSRTARRGSRSSIEPKTKSHTPPRRR--SSRSSP-ELTRKARVSRRSRSAS------- 1667

  Fly  1631 SRASSPATPLLTPLRNSRSPSMAA 1654
               |||.....||.|..||||:::
Mouse  1668 ---SSPEIRSRTPPRRRRSPSVSS 1688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21_SRRM2-like	52..100	CDD:410600	23/47 (49%)
		PTZ00121	<560..1154	CDD:173412	195/800 (24%)
		U2AF_lg	747..>876	CDD:273727	47/146 (32%)
		SRRM_C	<1584..1612	CDD:464573	12/40 (30%)
Srrm2	NP_001355616.1	cwf21_SRRM2	39..102	CDD:410601	27/62 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..1007		245/938 (26%)
		Sufficient for RNA-binding. /evidence=ECO:0000250	197..259		23/61 (38%)
		PHA03307	309..>686	CDD:223039	101/391 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1024..1112		11/87 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1136..2092		128/608 (21%)
		PHA03247	<1982..2466	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2263..2703
		PHA03307	2280..>2690	CDD:223039