DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and rhobtb3

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_691270.6	Gene:	rhobtb3 / 562804	ZFINID:	ZDB-GENE-091204-190	Length:	619	Species:	Danio rerio

Alignment Length:	687	Identity:	128/687 - (18%)
Similarity:	217/687 - (31%)	Gaps:	258/687 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   773 GNDCKRSI----SLTANGATDSGAGLMSIIDKLPIISKASSLSID-SSVSPYDDFSGSNPGISSC 832
            |::|...:    ..|::|....|. |.|.:..       .:..:| :|::|      |...::..
Zfish     9 GSECPGGVGPGDETTSSGQIQGGL-LWSYLGH-------GARELDPNSMTP------SRHPLNPA 59

  Fly   833 SEEEQGQVQGRIKKRRRDVQINETYDKSSLASVTEGILSKDLSPASNTDTDDLTFQQ-------- 889
            ..|.|.:|.|.::...||....:..| |...||...:...|:.....:..|.|.|||
Zfish    60 FMEYQSRVMGDVRVMVRDCPSWDILD-SDWVSVRSILEQADIVVIKYSVNDKLAFQQVRNGYAPR 123

  Fly   890 ----------------------DE-----------------------QLAKEQAELVSVPLQLTS 909
                                  ||                       ||::   :|.:..|:|.|
Zfish   124 LRPLLRHWGVPVILVAVGARLNDEGPPCTCPLCASDWSSCVPHSEGLQLSR---DLGATYLELPS 185

  Fly   910 SSN-----RTSSVMETII------EAKETASPKKQVTLSNGHTMESLHATIEKQKQLLETVNEHG 963
            .:|     ...||:|..:      :|||  .|.|:    .||.:                 ||..
Zfish   186 LNNFFVGRYFGSVLEYFMIQCLKQKAKE--RPDKR----RGHRL-----------------NEPR 227

  Fly   964 EQTTQQPSQIP------SSFVKLSDMDKPVKHDLQSPD------SMSKSVGNNH----------- 1005
            .....||:::|      |||.:  |:...::..:|..|      ...|.:|..|
Zfish   228 PPHLDQPARLPPVRVEESSFSQ--DLQWLLERGVQFADVAFYAGESGKELGWAHASVLCAVSPYF 290

  Fly  1006 RSSQLGQRLY---------RDENRARPHSWAMTRSTGNTLQNFTNSVDNI--------RSLSRL- 1052
            |...:|::.:         ||  |..|||         .|..:...||::        ..||||
Zfish   291 RQLLVGRQAWERPVSRCTCRD--RDGPHS---------LLSTWDGGVDDLPRADGHPPGHLSRLV 344

  Fly  1053 -----------------------FPNFSKEFSNSLPNGMTLEQVQGQQVDYIQTDLSADSSLASS 1094
                                   :....:..:..|.|.|.:.|:..:...::..: .|.....:.
Zfish   345 VKDPLLCLCLWETLMFLYRGAWEWEYLEEAIAEKLKNPMAVAQLMDRMRSFVGRE-KAPRDTPTP 408

  Fly  1095 FSRSGMDESSLSCRQPRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGH 1159
            .|:.|          |..||    .:|...:.:|::..|.|..:.||:.:|.:||...|||.:|.
Zfish   409 RSQQG----------PMTLG----SLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGK 459

  Fly  1160 GSQS---VVSLQGYSYAAVHFALCHIYSGASHPPDGISLMELAALADLLGLEGLKEVTAHALKTN 1221
            .:::   ||.:.|.|.......|.::|:....|...:..|.:...|::..::.|:.:
Zfish   460 YAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVLQAMAILVCAEMYQVKRLQHL-------- 516

  Fly  1222 YCHNFHKPCSGCSDGILQVLPV----------------ALNHALDDLYRKCLRWTCRHYLKV--- 1267
                    |..|....||.:|.                |..|..|.||...|.:...:||..
Zfish   517 --------CEVCVCAYLQSMPSRELASTGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIFSHK 573

  Fly  1268 ------------------WPTRQFAQLPPDILGRCRQ 1286
                              ||:|.:.|...:...|.||
Zfish   574 PDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQ 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	19/70 (27%)
		BTB	1128..>1191	CDD:197585	19/65 (29%)
		BACK	1238..>1281	CDD:197943	15/79 (19%)
rhobtb3	XP_691270.6	P-loop_NTPase	<97..189	CDD:304359	14/94 (15%)
		BTB	254..>296	CDD:295341	6/41 (15%)
		BTB	417..518	CDD:279045	25/120 (21%)
		BTB	428..518	CDD:197585	22/105 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910