DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13917 and AgaP_AGAP008362

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_317091.3	Gene:	AgaP_AGAP008362 / 1277617	VectorBaseID:	AGAP008362	Length:	1430	Species:	Anopheles gambiae

Alignment Length:	1239	Identity:	231/1239 - (18%)
Similarity:	358/1239 - (28%)	Gaps:	467/1239 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1053 FPNFSKEFSNSLPNGMTLEQVQGQQVDYIQTDLSADSS-----------LASSFSRSGMDESSLS 1106
            |..::....:||.||.....:..      .|..|.:|:           |....|::.:||||..
Mosquito     4 FIQYTLGIMSSLGNGNNQHNINS------NTGSSQNSAAEGTMERGSCILVRYASQNSLDESSQK 62

  Fly  1107 CRQPRRLG------------------EDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFA 1153
             :.||..|                  |.:..|..|.:..|:::...|..|.|||.:|.|...||.
Mosquito    63 -QLPRSNGKEKTTGAYRNNIHTQRSFEAMNMMREQNLLCDVVLVAEGIEIPAHKMVLASCSPYFY 126

  Fly  1154 AMLAG--HGSQSVVSLQGYSYAAVHFALCHIYSGASH-PPDGISLMELAALADLLGLEGLKEVTA 1215
            ||..|  ...|..::|||....|:...:.::|..... ..|.:.:  |...|:||.|..:::...
Mosquito   127 AMFTGFEESRQDRITLQGVDPRALQLLIEYVYRAVVEVTEDNVQI--LLTAANLLQLTDVRDACC 189

  Fly  1216 HALKTNYCHNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDI 1280
            ..|:|..     .| |.|    |.:...|..|...||......:..:|:.:|....:|..|..|
Mosquito   190 DYLQTQL-----DP-SNC----LGIRDFADIHGCIDLLNYAETYIEQHFSEVVQFDEFLNLTSD- 243

  Fly  1281 LGRCRQQIVAYMTSDTVL----DTVLDC------------DHLLAQLSAY-RWGHVCEQLVREIL 1328
                  |:...:.||.:.    :.|.:|            .|.||.|..: |...:.:..:.:.:
Mosquito   244 ------QVAHLIKSDRLSVPTEEKVYECVITWIQYDVSGRQHHLADLMEHVRLPLLSQDYLVQYV 302

  Fly  1329 EAAYAYVGDHFASLIASDSFLSL-------GHDRS-----RHIPR----LETLLL---------- 1367
            |......||    |...|..:..       |..::     |.|||    |..:||
Mosquito   303 EKEQLMKGD----LQCKDYIIEALKYHLLKGEQKTCFKTPRTIPRQPVGLPKVLLVIGGQAPKAI 363

  Fly  1368 -------------HTAAELTPEQACRS--------YQRVTRLNTVLQAKVI-------------- 1397
                         :..||: |.:.||:        ...|...|..|:.|.:
Mosquito   364 RSVECYDLREEKWYQVAEM-PTRRCRAGLAVLGDKVYAVGGFNGSLRVKTVDVYDPVLDQWTTSH 427

  Fly  1398 HMPA---SLGQSELAREL---------QGLQEEQL------DWQ----------PEYIRLVGALV 1434
            :|.|   :||.:.|...:         .||...::      :|:          ...:.:|..|:
Mosquito   428 NMEARRSTLGVAVLNHCIYAVGGFDGSTGLSSAEMFDPKRQEWRLIASMSTRRSSVGVGVVNGLL 492

  Fly  1435 YAV-------EQCLIRQCSRAMRVTAW-QRMDLELRKK---IQTLARL---------------TE 1473
            |||       .|||............| |..::..|:.   :..|..:               .|
Mosquito   493 YAVGGYDGASRQCLASVERYNPSTDTWTQIAEMSARRSGAGVGVLDNILYAVGGHDGPLVRKSVE 557

  Fly  1474 PLDMKRQNGKPV----------------GKAFSFGGSTRSQDLVQIKL----------------- 1505
            ..|......:||                |..:..||.....:|..:::
Mosquito   558 AYDPATNTWRPVGDMAFCRRNAGVVAHNGMLYVVGGDDGLSNLASVEVYSPETDWRILPSSMSIG 622

  Fly  1506 ----------------AIQAQTKRANAQETLMYKATQTQDA------------------------ 1530
                            |.......||..|....:....:.|
Mosquito   623 RRAGVAMIDKPFPQNEAASLPAAGANDDENSQAEGLNPEPAMNNAPNGNSVHYENIYESIEQFAP 687

  Fly  1531 --AGGAGHVQTADRGVQA------------------NHESREGGS---------KLLKSNSRAYV 1566
              .||.|. ..|..|:.|                  :..|..||:         .:|.|..:.|.
Mosquito   688 LNGGGVGG-NGAPAGIPAVSNPAPQHAAANQPQPGPSGRSLNGGAAACIPPPPPSMLHSMQQLYH 751

  Fly  1567 PHRASSQVATERNSLNLHRRTQS-------EAPPVTHKKPITVAASTVESKSAQGKPNAAAAKLG 1624
            |       ...||  .|:.||..       .||.....:|....:|.....:.....|.|...:|
Mosquito   752 P-------MAYRN--ELYDRTAGYDVPRGRPAPSYYQNQPPVAGSSNGRYANLHLDLNRARYPVG 807

  Fly  1625 EVRPRYLEPRKPR------------------------------------------AMAPSATN-- 1645
            ...|:  :||.||                                          :.||:|..
Mosquito   808 SAAPQ--QPRPPRQRSFDDTESYHYYRCHSQSNGVAKCDNLYERVREEPAYQNTGSFAPAANRAA 870

  Fly  1646 ---------GHGAGPVRSATSSSIP-----ANGGRKAPAKNLHISSSDSSRNSSPAARR--VQNG 1694
                     |||.|.:....|||..     :.||..|...:.|:.:....|.:.|.|..  ..|.
Mosquito   871 GLFGRFDVIGHGVGRIERHLSSSCGNIDHYSLGGHYAVLGHSHLGTVGHIRLNQPGANAPGSTNA 935

  Fly  1695 TRLGNKSSNLSMDSLASPARRAKSSSRGPQERYSSDQNSLAESMKSSVITNKTISHESLSGSSKL 1759
            ....|.::|      |.|.....|||...:..:|......::||.:   .||..:....:|.|
Mosquito   936 PYCANGTAN------AQPNATKDSSSVNVKSFFSCLGGENSQSMNN---LNKPSTANGAAGGS-- 989

  Fly  1760 ARIQQINGHSK---GAATGKIKATQRGSTVGNKSTRQLKQQHNAMASNGSSPSSVHTTKSAASRL 1821
              :...||:..   |||.|...|:..|::.|               :.|...|.:....|||
Mosquito   990 --VNAANGNDSTLAGAAGGAGGASSGGASGG---------------TGGQGGSIMGGLASAA--- 1034

  Fly  1822 SSVSSTLSTRELFKQRSISVPAGGTDGAPNKGRHSFLSAKSREILAKRAEKNKLQQQQQQQKQTE 1886
                            ::.|...||.|.        |..||...:.|.:.|:|..||...|:.|
Mosquito  1035 ----------------AVGVSGVGTGGT--------LGGKSTGAIPKISRKSKQSQQSAAQEPT- 1074

  Fly  1887 APVEERGSVQLRSSAGPLRSSSHSAVSSMLQQHNLRNSLPSNIPTRRPNTLHLKKTTAATNGVGG 1951
            |.|....|:   :|.|.|.                    |:::.|..|         ...|||||
Mosquito  1075 ANVPAPPSL---ASVGGLP--------------------PADLSTADP---------MYANGVGG 1107

  Fly  1952 GPTK 1955
            ..||
Mosquito  1108 RVTK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	21/69 (30%)
		BTB	1128..>1191	CDD:197585	19/65 (29%)
		BACK	1238..>1281	CDD:197943	10/42 (24%)
AgaP_AGAP008362	XP_317091.3	BTB	90..193	CDD:279045	27/104 (26%)
		PHA03098	91..612	CDD:222983	102/544 (19%)
		BACK	201..303	CDD:285009	21/112 (19%)
		Kelch	351..396	CDD:128874	7/45 (16%)
		KELCH repeat	386..429	CDD:276965	6/42 (14%)
		Kelch	397..442	CDD:128874	8/44 (18%)
		KELCH repeat	433..476	CDD:276965	6/42 (14%)
		Kelch	444..490	CDD:128874	4/45 (9%)
		KELCH repeat	480..526	CDD:276965	10/45 (22%)
		Kelch	491..539	CDD:128874	11/47 (23%)
		KELCH repeat	529..572	CDD:276965	5/42 (12%)
		Kelch	541..586	CDD:128874	4/44 (9%)
		Kelch_1	576..617	CDD:279660	4/40 (10%)
		KELCH repeat	576..617	CDD:276965	4/40 (10%)
		SEEEED	<1361..1428	CDD:291463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910