Protein Alignment CG12099 and rnf10

DIOPT Version :10

• Sequence 1: NP_647623.1
• Gene: CG12099 / 38181
• FlyBaseID: FBgn0035232
• Length: 708
• Species: Drosophila melanogaster
• Sequence 2: NP_596530.1
• Gene: rnf10 / 2541365
• PomBaseID: SPBP8B7.23
• Length: 673
• Species: Schizosaccharomyces pombe
• Alignment Length: 771
• Identity: 178/771 - (23%)
• Similarity: 320/771 - (41%)
• Gaps: 181/771 - (23%)

  Fly     1 MDSNNSSNSKKQPQSSHHGKSSS--AESQRKSSELHTNSNKQRHSRRRNQVPTPRNDQQQQPQQP 63
            |.||::|:||...:|.:...|||  ..|..|:.|...:....|:|.::.|....:|.|....::.
pombe    12 MPSNSNSSSKLNAKSPNFIPSSSNIPRSSAKTKEHSADRKPHRNSEKKTQGMPRKNQQLASSERK 76

  Fly    64 AKLRPNVDKRPKARGFGGGYDFPSPRGQDGASGSSRLAYSATGYSRSGDFDHELNSVYTQGSKKQ 128
            .|.:..::|:..|.....|.....|:               |.|      |..|..:.:..:.|:
pombe    77 TKNKKRLEKQSSAIADSIGESLDDPQ---------------TVY------DEHLFDILSARTNKR 120

  Fly   129 ---NLNHLLNFHCVPR----------ELERGH--HHQAQQHHGLSGRKQRYNKEQFLQANFQFVI 178
               ||||||||...||          ...||:  :.|...||.:       :|.:::.||::||:
pombe   121 GQINLNHLLNFQFTPRTNSNAFSAPPRRSRGYNTYGQGSGHHPM-------DKSRYVNANYRFVV 178

  Fly   179 RS-GAKAQVNGSPDALIDWSYIEQINIQTTEEL-QCPICL-YPPVAAKLTRCGHAYCWPCLLHYL 240
            .. |........||:.:.|..:.|:...:..:| .||.|| ..||||:::||||.||:.|||.::
pombe   179 SPIGDYQSQKLDPDSPVKWEDVWQVLCSSDFQLAACPFCLEEKPVAARMSRCGHVYCFSCLLRFV 243

  Fly   241 SLSDKT----------------WRKCPICYDAIHAGD---LKSCTIEQLRDLQVGEKITFQLMRR 286
            ......                .|.||||:|:|...|   ::....::.:.|:.|:.:..:|.:|
pombe   244 ETPTAAEVKAAETSGTKIVKCGHRSCPICWDSIRLRDVHPIRWVEDKEFQKLEEGKSVCLRLYQR 308

  Fly   287 RKGSMYIENHVAGLGETIERFP-------------------FVSAGEEAKRYSKFLIAKR--MDV 330
            ..||             |..||                   |..:|   ..|::.:|...  |..
pombe   309 NNGS-------------ILAFPRSCRSFALDGSFHSDEIPNFTMSG---AAYARIIIGSHDYMVQ 357

  Fly   331 AAIIERERNELLAESDVSC--PEDVFIQQALVMLQERVEKL--GVEKPDPKEDEEETAPVLCLET 391
            ..::|.|:.:.:|..|:|.  ..|.:.::...:|.:|:..|  .|.:.:.|..:.: ...|||::
pombe   358 QHLLEIEQLQQIAAEDISLYGSADTYYERITQILLDRISSLSESVNEQNIKSLQTD-IDNLCLQS 421

  Fly   392 ETKIDIEKSDDAS-ISSGEASSSLSYSSNHNKYYYFYQSNDGQNIYLHPLNVKMLQACYGTLDLG 455
            .:...:.:.||.: :|..|.:.:          |.|||.....:|||.||::::|::.:|:.:..
pombe   422 NSLKQLSEVDDLNDVSGSEIADA----------YLFYQPFAHSHIYLSPLDIRILKSAFGSYENF 476

  Fly   456 PLLIEAQIVQMEQ-HSMDEEHRRKFTCLGHLPLTCQFSVVEVELQPPVVTGGILKLFKEDILHRK 519
            |..:..::.::.. |.::.|.|::|..:.|||..|:.:.:|.:.. .::...:|..||.:|..|:
pombe   477 PDELVPRVERISSGHLVNSELRQRFKYMAHLPEGCEVAFIECDWS-KIIPKEVLLTFKSEISKRR 540

  Fly   520 KERQRRD-REERKREQHINEINDRQMGKLIASAANLDLSSSHEFPTCGFEEALPAPSGSVPMNIS 583
            |:|:.:: ||||.|::     .:|...:.|.|..|:                    ...||..:.
pombe   541 KQRKAQEMREERYRQR-----AERDTEEQIYSELNM--------------------QRPVPKTVV 580

  Fly   584 NQDPGSRYSSVTLGSPKQ-EMWPTIGSNSPGGGGAPLDVQVGAWGRSAPPPPRAVMVPRTSDEDF 647
            ::||...:.  ||||..| |....:.::.     :.|......||..|       :....:|.|
pombe   581 HEDPAEAFP--TLGSHHQFESTDEVNTDE-----STLSTAKTVWGTRA-------LANIQNDTD- 630

  Fly   648 EQRSVGHWGLGELLVGALDQKKQKVGAAKSNGAAPAESKKQKKAKGKKMVPLFATG 703
            :|..:..|.:....|..|              :||:::.|.||   ||.:.|.:||
pombe   631 DQDDLDGWKVDWDKVAQL--------------SAPSKNSKNKK---KKKLVLLSTG 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12099	NP_647623.1	RING-HC_RNF10	211..263	CDD:438198	25/71 (35%)
rnf10	NP_596530.1	RING_Ubox	214..282	CDD:473075	25/67 (37%)