Protein Alignment SA2 and scc-3

DIOPT Version :10

• Sequence 1: NP_612109.3
• Gene: SA2 / 38167
• FlyBaseID: FBgn0043865
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_506193.1
• Gene: scc-3 / 179749
• WormBaseID: WBGene00004738
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 1034
• Identity: 235/1034 - (22%)
• Similarity: 423/1034 - (40%)
• Gaps: 212/1034 - (20%)

  Fly    45 DATNKSLLQMILSRKRLSPTNKRNSHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPD 109
            :..::.|:..:.|.|:::         |:|.::.|. |.:....|:..:.||...:.|....:..
 Worm   106 EVDDRELVAAVKSGKKIT---------EAVDRWIGR-YNEKFLVAIAEMHQFFFAICGCKGIVTP 160

  Fly   110 DTSMPFSYSDILSNSSSHF-SNTHIYPLIRKPA--DVFVNQVGSFLNALLLVANKFRSDSYQLF- 170
            ..|...:|.||:...:..| .::..|||:...:  .|..| :.:|::.|::     |:.:..||
 Worm   161 QMSATLTYKDIICRMTEDFEEDSADYPLVHGGSLKKVRAN-LHNFIHTLII-----RTKASMLFD 219

  Fly   171 ------LVQLTNFVMACSESNIRTFRHTATMIGLKIMTILSDL------------KSLD------ 211
                  .|||   :...::|.:|.||||||...:||.:.|.|:            |.::
 Worm   220 SNLMDGFVQL---LTGMADSQVRAFRHTATFCAMKITSALVDVTIELTQSKEKTSKQIEAEKAKL 281

  Fly   212 ------------------------DEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFAR 252
                                    :||...:. .:|.|:||.|.||:|.|||.:||.|||.|...
 Worm   282 KNNSAGNEKYEALVAQRTQTEERAEEIRQIIG-YLFRSVFVHRYRDVVPDIRCICIQELGHWMDV 345

  Fly   253 YPHCHLQPTSLRIFYEALNDGSGDVIQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKE 317
            ||...::.:.|:....::.|..|||.|..:..:..|..|.::..::....::|::.||.:.|.|:
 Worm   346 YPEHFVEDSYLKYIGWSMFDKVGDVRQRCIRALIPLFEKTLILDKLELFVNKFKDRLVSMLLDKD 410

  Fly   318 DAIAEKSVQFLTHFHVLSAEILT-DDVCRVLEQLIMAANRGLAQAAADLF----ILRRNGLDGE- 376
            ...:.::|..:...:.:...:|| .||..:.| ||.|:||.|| .||.:|    :.|.....|:
 Worm   411 LETSIETVHLMRVLYTVFPTLLTIKDVVPIYE-LIYASNRPLA-VAAGMFLNTKVFRSAEKPGKA 473

  Fly   377 ---TFCQRVKHLLQLFIECG-HEQADYLVDSLIDNCELVLDWKSMIAVLLENPKSRELSDIHCSS 437
               .....||.|...|||.. |:.|.||||:|.::..:|.||.:|..:|:.:  ..:|.....:.
 Worm   474 PTAANIPLVKDLTTFFIEGDLHQHATYLVDALFESNPIVKDWATMGELLIND--QYQLDSNFETK 536

  Fly   438 LIAILLAGVKQATAGEIPPGRY-----------TKDLKREPRQGAQERATKCLAPVLPELLRTYA 491
            ||.||...|.|:..||.|.||:           ::||..:     ::|.|:.|.|::|.|:..::
 Worm   537 LIEILTCSVVQSATGEPPVGRHIVKKGAPSAKESRDLVED-----RQRLTETLIPLIPRLITKFS 596

  Fly   492 NRLQDIERLLELPKYFCFDYYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLEFLNRMI 556
            :..:.|..|:.:|.:|..:.|........|.||:|..:.:| ::.....:|:...:....|.
 Worm   597 SDNEKIINLVNIPLHFQLETYLSARMQTHLMELMEGLDSLI-EKHLDEELLKAVAELYYHLT--- 657

  Fly   557 PIPLTKQLLNSAVTNYKM-------AWHR--TQDTSPSRSTHNESNRLLATLRLLTVLSGHFNLS 612
                |...:::.|..:||       |:.|  .|.....:....|....::.::.:...:|..:|.
 Worm   658 ----TNSSISALVEGHKMKLLDGVAAFIRKSMQQFDDDQMGEEEEALFVSYIKRMAAFAGFMDLR 718

  Fly   613 KWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKACFCCLCWDMENL--EG----------- 664
            .|||.:.|   ||::....|    :|...:.....::..|..||:|..|:  ||
 Worm   719 HWDLWDIL---LKVVSNYTR----EDTQRDVRERSMQMLFMQLCFDSMNIKKEGETPKADQVRKL 776

  Fly   665 ------------TALNNVDMDEYCDVLHHNLEDYLYVTFSLVGKSNTEPLAYPCFSYTCDLFVLH 717
                        ..||    :|.|.|    .:.||.:                     |||.:|.
 Worm   777 KKRRDQLIRIVTETLN----EEACGV----EQAYLVI---------------------CDLMILF 812

  Fly   718 GNLCGSSNPSIRSVAHVPSGNELDILEGFLMEHFLELSPSDLMLETNSDQLQRI------RSILT 776
            |:.....:.::..:...|....|..|:.||..:..::|..|.|     ||.::|      |..:.
 Worm   813 GSQLAEESKALEPLIWRPDAMVLGNLKIFLDVNVFDVSNLDDM-----DQQEKIEVMHKMRQHVA 872

  Fly   777 SYLKVVCLGVVPTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVF 841
            .|.|::..|.:|...||...:.|..:...|||:.:..:....:.:.:...:.:..|...||:::.
 Worm   873 QYAKLIIHGAMPVAEASHLIKRYQSHFQDFGDIFKNLLSKCREISFVETGVMICETLKTLYSQLD 937

  Fly   842 PDDTRHAAGQRALRPAEFSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEA 906
            .|.......:      .|:.:.:||.||......:..::|..:.:||:..|.|.||...|:..:.
 Worm   938 EDQGTDPLSE------SFNSIRDLAKRLGPAFGVDYAKNRFAISSLHKKAIDFAFEEYDKENHQM 996

  Fly   907 TKKLPFLRVLKVFVPLLLVQDKTRILNF---------------FEPYEQLIIPTCNRND 950
            .|.:.||.:...|...||.|||..::.:               :|||...:....:|||
 Worm   997 PKNIFFLEIAIEFSGKLLAQDKMAVVRYLNKIYTNRVGTSTVVWEPYRLYLGSLSDRND 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA2	NP_612109.3	IRR1	<115..>329	CDD:227824	65/265 (25%)
		STAG	132..>215	CDD:462502	27/133 (20%)
scc-3	NP_506193.1	IRR1	93..>406	CDD:227824	74/319 (23%)
		STAG	184..286	CDD:462502	26/110 (24%)