DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and scc-3

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_506193.1	Gene:	scc-3 / 179749	WormBaseID:	WBGene00004738	Length:	1096	Species:	Caenorhabditis elegans

Alignment Length:	1034	Identity:	235/1034 - (22%)
Similarity:	423/1034 - (40%)	Gaps:	212/1034 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DATNKSLLQMILSRKRLSPTNKRNSHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPD 109
            :..::.|:..:.|.|:::         |:|.::.|. |.:....|:..:.||...:.|....:..
Worm   106 EVDDRELVAAVKSGKKIT---------EAVDRWIGR-YNEKFLVAIAEMHQFFFAICGCKGIVTP 160

  Fly   110 DTSMPFSYSDILSNSSSHF-SNTHIYPLIRKPA--DVFVNQVGSFLNALLLVANKFRSDSYQLF- 170
            ..|...:|.||:...:..| .::..|||:...:  .|..| :.:|::.|::     |:.:..||
Worm   161 QMSATLTYKDIICRMTEDFEEDSADYPLVHGGSLKKVRAN-LHNFIHTLII-----RTKASMLFD 219

  Fly   171 ------LVQLTNFVMACSESNIRTFRHTATMIGLKIMTILSDL------------KSLD------ 211
                  .|||   :...::|.:|.||||||...:||.:.|.|:            |.::
Worm   220 SNLMDGFVQL---LTGMADSQVRAFRHTATFCAMKITSALVDVTIELTQSKEKTSKQIEAEKAKL 281

  Fly   212 ------------------------DEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFAR 252
                                    :||...:. .:|.|:||.|.||:|.|||.:||.|||.|...
Worm   282 KNNSAGNEKYEALVAQRTQTEERAEEIRQIIG-YLFRSVFVHRYRDVVPDIRCICIQELGHWMDV 345

  Fly   253 YPHCHLQPTSLRIFYEALNDGSGDVIQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKE 317
            ||...::.:.|:....::.|..|||.|..:..:..|..|.::..::....::|::.||.:.|.|:
Worm   346 YPEHFVEDSYLKYIGWSMFDKVGDVRQRCIRALIPLFEKTLILDKLELFVNKFKDRLVSMLLDKD 410

  Fly   318 DAIAEKSVQFLTHFHVLSAEILT-DDVCRVLEQLIMAANRGLAQAAADLF----ILRRNGLDGE- 376
            ...:.::|..:...:.:...:|| .||..:.| ||.|:||.|| .||.:|    :.|.....|:
Worm   411 LETSIETVHLMRVLYTVFPTLLTIKDVVPIYE-LIYASNRPLA-VAAGMFLNTKVFRSAEKPGKA 473

  Fly   377 ---TFCQRVKHLLQLFIECG-HEQADYLVDSLIDNCELVLDWKSMIAVLLENPKSRELSDIHCSS 437
               .....||.|...|||.. |:.|.||||:|.::..:|.||.:|..:|:.:  ..:|.....:.
Worm   474 PTAANIPLVKDLTTFFIEGDLHQHATYLVDALFESNPIVKDWATMGELLIND--QYQLDSNFETK 536

  Fly   438 LIAILLAGVKQATAGEIPPGRY-----------TKDLKREPRQGAQERATKCLAPVLPELLRTYA 491
            ||.||...|.|:..||.|.||:           ::||..:     ::|.|:.|.|::|.|:..::
Worm   537 LIEILTCSVVQSATGEPPVGRHIVKKGAPSAKESRDLVED-----RQRLTETLIPLIPRLITKFS 596

  Fly   492 NRLQDIERLLELPKYFCFDYYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLEFLNRMI 556
            :..:.|..|:.:|.:|..:.|........|.||:|..:.:| ::.....:|:...:....|.
Worm   597 SDNEKIINLVNIPLHFQLETYLSARMQTHLMELMEGLDSLI-EKHLDEELLKAVAELYYHLT--- 657

  Fly   557 PIPLTKQLLNSAVTNYKM-------AWHR--TQDTSPSRSTHNESNRLLATLRLLTVLSGHFNLS 612
                |...:::.|..:||       |:.|  .|.....:....|....::.::.:...:|..:|.
Worm   658 ----TNSSISALVEGHKMKLLDGVAAFIRKSMQQFDDDQMGEEEEALFVSYIKRMAAFAGFMDLR 718

  Fly   613 KWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKACFCCLCWDMENL--EG----------- 664
            .|||.:.|   ||::....|    :|...:.....::..|..||:|..|:  ||
Worm   719 HWDLWDIL---LKVVSNYTR----EDTQRDVRERSMQMLFMQLCFDSMNIKKEGETPKADQVRKL 776

  Fly   665 ------------TALNNVDMDEYCDVLHHNLEDYLYVTFSLVGKSNTEPLAYPCFSYTCDLFVLH 717
                        ..||    :|.|.|    .:.||.:                     |||.:|.
Worm   777 KKRRDQLIRIVTETLN----EEACGV----EQAYLVI---------------------CDLMILF 812

  Fly   718 GNLCGSSNPSIRSVAHVPSGNELDILEGFLMEHFLELSPSDLMLETNSDQLQRI------RSILT 776
            |:.....:.::..:...|....|..|:.||..:..::|..|.|     ||.::|      |..:.
Worm   813 GSQLAEESKALEPLIWRPDAMVLGNLKIFLDVNVFDVSNLDDM-----DQQEKIEVMHKMRQHVA 872

  Fly   777 SYLKVVCLGVVPTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVF 841
            .|.|::..|.:|...||...:.|..:...|||:.:..:....:.:.:...:.:..|...||:::.
Worm   873 QYAKLIIHGAMPVAEASHLIKRYQSHFQDFGDIFKNLLSKCREISFVETGVMICETLKTLYSQLD 937

  Fly   842 PDDTRHAAGQRALRPAEFSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEA 906
            .|.......:      .|:.:.:||.||......:..::|..:.:||:..|.|.||...|:..:.
Worm   938 EDQGTDPLSE------SFNSIRDLAKRLGPAFGVDYAKNRFAISSLHKKAIDFAFEEYDKENHQM 996

  Fly   907 TKKLPFLRVLKVFVPLLLVQDKTRILNF---------------FEPYEQLIIPTCNRND 950
            .|.:.||.:...|...||.|||..::.:               :|||...:....:|||
Worm   997 PKNIFFLEIAIEFSGKLLAQDKMAVVRYLNKIYTNRVGTSTVVWEPYRLYLGSLSDRND 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	28/133 (21%)
scc-3	NP_506193.1	STAG	184..286	CDD:285686	26/110 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820