Protein Alignment SA2 and STAG2

DIOPT Version :10

• Sequence 1: NP_612109.3
• Gene: SA2 / 38167
• FlyBaseID: FBgn0043865
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001036214.1
• Gene: STAG2 / 10735
• HGNCID: 11355
• Length: 1268
• Species: Homo sapiens
• Alignment Length: 1096
• Identity: 270/1096 - (24%)
• Similarity: 468/1096 - (42%)
• Gaps: 190/1096 - (17%)

  Fly     3 DISFDDAVLNDSQA--SNQMDFEIREECSIAPNDEPVCVDGTVGDAT-----NKSLLQMILSRKR 60
            :|..|..:|.:|:.  |:..|||..|..:........|..|..|.|.     |.       ..|.
Human     6 EIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCKKGKKGPAEKGKGGNG-------GGKP 63

  Fly    61 LSPTNKRNSH---------------------IESVAKYWGEFYLDSPTAALVALLQFVVEVSGSH 104
            .|..|:.|.|                     ::||...|.|.|......||:.|:.|.::.||..
Human    64 PSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCK 128

  Fly   105 YQIPDDTSMPFSYSDILSNSSSHF-SNTHIYPLI------RKPADVFVNQVGSFLNALLLVANKF 162
            ..:..:.......|:|:...:..| .::..|||.      :|....|...:|      :||....
Human   129 GVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG------VLVRQCQ 187

  Fly   163 RSDSYQLFLVQ-LTNFVMACSESNIRTFRHTATMIGLKIMTIL---------------------- 204
            .|..|..:::. :.:.:...|:|.:|.||||:|:..:|:||.|
Human   188 YSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAER 252

  Fly   205 -------------------SDLKSLDDEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWF 250
                               .:|:...|||. .:...:|..:||.|.||.:.:||.:||.|:|.|.
Human   253 NKMIGKRANERLELLLQKRKELQENQDEIE-NMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWM 316

  Fly   251 ARYPHCHLQPTSLRIFYEALNDGSGDV-IQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCL 314
            ..|....|..:.|:.....::|..|:| ::| |..:..|.....|.|::...||.|::.:|.:.|
Human   317 KMYSDAFLNDSYLKYVGWTMHDKQGEVRLKC-LTALQGLYYNKELNSKLELFTSRFKDRIVSMTL 380

  Fly   315 GKEDAIAEKSVQFLTHFHVLSAEILTDDVCRVLEQLIMAANRGLAQAAAD-----LF-------- 366
            .||..:|.::::.||.....|.|:||.:.|..:..|:.:|:|.:|.||.:     ||
Human   381 DKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEED 445

  Fly   367 -ILRRNGLDGETFCQRVKHLLQLFIECG-HEQADYLVDSLIDNC--ELVLDWKSMIAVLLENPKS 427
             :::|.|..|.. ...||.|:..|:|.. ||.|.|||||:.| |  ||:.||:.|.::|||.|.|
Human   446 GMMKRRGRQGPN-ANLVKTLVFFFLESELHEHAAYLVDSMWD-CATELLKDWECMNSLLLEEPLS 508

  Fly   428 RE--LSDIHCSSLIAILLAGVKQATAGEIPPGRYTKD---LKREPRQGAQERA--TKCLAPVLPE 485
            .|  |:|...|:||.|:|..::||.....|.||.|..   ..:|.:....:|.  |:..|..||:
Human   509 GEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTKITELFAVALPQ 573

  Fly   486 LLRTYANRLQDIERLLELPKYFCFDYYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLE 550
            ||..|:...:.:..||:||:||..:.|........|:.|:.....|: ::.:.|.||:...||..
Human   574 LLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIV-EKHTDTDVLEACSKTYH 637

  Fly   551 FL--------NRMIPIPLTK-QLLNSAVTNYKMAWHRTQD--TSPSRSTHNESNRLLATLRLLTV 604
            .|        ||   :.::: ||::.....:.   ...:|  ........:::.::|:||:.:|.
Human   638 ALCNEEFTIFNR---VDISRSQLIDELADKFN---RLLEDFLQEGEEPDEDDAYQVLSTLKRITA 696

  Fly   605 LSGHFNLSKWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKAC-FCCLCWDMENLEGTALN 668
            .....:|||||     ||:....|.:..:.|||  .||...::...| ...:.|.:..:..::..
Human   697 FHNAHDLSKWD-----LFACNYKLLKTGIENGD--MPEQIVIHALQCTHYVILWQLAKITESSST 754

  Fly   669 NVD-------MDEYCDVLHHNLEDYLYVTFSLVGKSNTEPLAYPCFSYTCDLFVLHGN-LCGSSN 725
            ..|       |..:|.:..|      |:|     ..|| .:....|:..||:.::..: :.....
Human   755 KEDLLRLKKQMRVFCQICQH------YLT-----NVNT-TVKEQAFTILCDILMIFSHQIMSGGR 807

  Fly   726 PSIRSVAHVPSGNELDILEGFLMEH-FLEL----SPSDLMLETNSDQLQRI---RSILTSYLKVV 782
            ..:..:.:.|..:....|..|:::| |:|.    :.:|...|..:.:::.:   |::|.::.|::
Human   808 DMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALHKRRNLLAAFCKLI 872

  Fly   783 CLGVVPTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVFPDDTRH 847
            ...||....|:..::.|:||:..:||:::.:|....|.:.|..|.|::.:...|:.::..::
Human   873 VYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMIQEN--- 934

  Fly   848 AAGQRALRPAE-FSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEATKKLP 911
              |....|.:. ||.:.|||.|.|.....:.::.||.:..||:.||.|.|    |:|....:..|
Human   935 --GYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIEFAF----KEPNPQGESHP 993

  Fly   912 -----FLRVLKVFVPLLLVQDKTRILNFFEPYEQLIIPTCNRNDI-AHLKEYRNAL 961
                 ||.:|..|...||.|||..:..:.|.:....: :..|.|: ..|..|||:|
Human   994 PLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQM-SLRREDVWLPLMSYRNSL 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA2	NP_612109.3	IRR1	<115..>329	CDD:227824	61/263 (23%)
		STAG	132..>215	CDD:462502	25/130 (19%)
STAG2	NP_001036214.1	IRR1	102..>395	CDD:227824	70/300 (23%)
		STAG	157..270	CDD:462502	22/118 (19%)