DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and LOC100333021

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_009305909.3	Gene:	LOC100333021 / 100333021	-ID:	-	Length:	1105	Species:	Danio rerio

Alignment Length:	1062	Identity:	254/1062 - (23%)
Similarity:	433/1062 - (40%)	Gaps:	243/1062 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NDSQASNQMDFEIREECSIAPNDEPVCVDGTVGDAT----NKSLLQMILSRKRLSPTNKR----- 67
            :||.:....|||.:.:.|...      |:.|.|.|:    ::.....:.|.:..:||:..
Zfish     9 DDSISLTGSDFEFQLKTSKRK------VNSTQGVASPNRVHRRPASALSSSQSQAPTDSEGGVST 67

  Fly    68 ----------NSHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPDDTSMPFSYSDILS 122
                      .|.:.:|...|.|.|.....|.|:.|:.|||:.||....:..:.......:||:|
Zfish    68 AYLYEAVRSGRSALTTVIDDWLEEYQRDKEAGLLELINFVVQCSGCKGVVSREMLSSLQNADIIS 132

  Fly   123 NSSSHFSNTHI-YPLI------RKPADVFVNQVGSFLNALL------LVANKFRSDSYQLFLVQL 174
            :.:..|:...: |||:      |:    |...|..|:..|:      |:.:.|...|   |:..|
Zfish   133 HLTKEFNEDSVSYPLVSSGPQWRR----FSEGVCEFVCVLVRGCRNTLLYDDFLFSS---FIALL 190

  Fly   175 TNFVMACSESNIRTFRHTATMIGLKIMTIL-----------------SDL--------KSLD--- 211
            |..    ::|.:|.||||::.|.:::|:.:                 |||        :::|
Zfish   191 TGL----ADSQVRAFRHTSSFIAMRLMSSIVSVAADVNIQAQMIQRRSDLEKSKPAEERAIDRLE 251

  Fly   212 ------------DEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFARYPHCHLQPTSLR 264
                        .|...::...:|..:||.|.||::.:||.:|:.|:|.|....|...|....|:
Zfish   252 ELEHSYRELMEQQEDLRSLMNGIFKGVFVHRYRDVIPEIRAVCMEEMGVWLRENPAHFLNDEHLK 316

  Fly   265 IFYEALNDGSGDV-IQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKEDAIAEKSVQFL 328
            .....|:|....| :||.|....:...||.| |.:...||.|:|.::.:.|.|:..:|.::|:.|
Zfish   317 YVGWMLHDKQAAVRLQCVLTLQKLFEEKDFL-SRLEFFTSRFKERILCMILDKDSDVAVETVKLL 380

  Fly   329 THFHVLSAEILTDDVCRVLEQ-----LIMAANRGLAQAAADLFILRRNGLDGETFC--------Q 380
                 |..:..|||.....|:     |:.|.:|||| .||..|:.       .|.|        .
Zfish   381 -----LLIQTQTDDGLSASERAAVYPLVFATHRGLA-CAAGRFLY-------HTLCCAADQSSDS 432

  Fly   381 RVKHLLQL----FIECG-HEQADYLVDSLID--NCELVLDWKSMIAVLLENPKSRELSDIHCSSL 438
            |...:|:|    ||:.. |:.|.||||||.|  ..|| .||:.|.::||::...:|..:   |:|
Zfish   433 RSVSILRLLALFFIQSEYHDHAAYLVDSLWDVAGAEL-KDWELMTSLLLQDSSLQEQLE---SAL 493

  Fly   439 IAILLAGVKQATAGEIPPGR-YTKDL-KREPRQGAQE--RATKCLAPVLPELLRTYANRLQDIER 499
            |.|::..|:||.....|..| :.|.: .|:.|..||:  |.:....||||:||..::..:..:.|
Zfish   494 IDIMMCAVRQAAEATPPTARAHRKSVTARQKRVQAQDQRRISSVFMPVLPQLLAKFSADVGKVSR 558

  Fly   500 LLELPKYFCFDYYHEQNRMGQ-LNELVEHFELIIFDQTSSTTVLQITVK-----TLEFLNRMIPI 558
            ||..|.:|..:.|....|:.: |::|:             :.|..||:|     .||...|::.:
Zfish   559 LLRAPLHFQLEVYGTSGRLEKSLDQLL-------------SQVCDITLKHHEECVLEACVRVLCV 610

  Fly   559 PLTK-------------QLLNSAVTNYKMAWHRTQDTSPSRSTHNESNRLLATLRLLTVLSGHFN 610
            ..::             |||::.|..:..   ..::.....:..::..|..::|.:|.:.|
Zfish   611 LCSEGYTFCGRAETAVGQLLDTTVEKFTA---NLEEILQGSADEDDLYRAASSLNILAIFS---- 668

  Fly   611 LSKWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKACFCC---LCWDMENLEGTALNNVDM 672
             |..||||..||.....|.:..:..|:    .:..|.:.|..||   |.|..........:..:.
Zfish   669 -SARDLTERNLFEFCFQLLKMGVETGE----ISEKLMVPALSCCAYQLLWSAHRNTQRRTDKAEA 728

  Fly   673 DEYCDVLHHNLEDYLYVTFSLVGKS----NTEPLAYPCFSYTCDLFVLHGNLC----GSSNPSIR 729
            ......||         :|.::.:|    ...|:....|...|||.::   .|    ||.:|
Zfish   729 RRVLKSLH---------SFCVLCQSCLSIALSPVRSKAFVCVCDLLLV---FCRPPEGSISP--- 778

  Fly   730 SVAHVPSGNELDILEGFLMEHFLELSPSDLMLE--------TNSDQ------LQRIRSILTSYLK 780
                         |:.|..:..|....:..:|:        |..|:      ||: |:.|:.|.|
Zfish   779 -------------LQRFSPDESLRAEMASFVLDYVFGDEDLTGEDEEMMTALLQK-RNHLSGYCK 829

  Fly   781 VVCLGVVPTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVFPDDT 845
            ::..||:....|:....||.:::..|||:::.::..:...|....|.|:......|||.:   |.
Zfish   830 LIIYGVLELQAATDILRYYHRFYKDFGDIIKETLNKSKMINSEDSARTVCLCLQQLYAGL---DL 891

  Fly   846 RHAAGQRALRPAEFSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEATKKL 910
            :...|       |..|:..||.:||.....|....|:.:::||:.||.|..:..:|  .|| ..|
Zfish   892 QCCDG-------ELMEIRLLAKKLAMNFSINLRLVRKPLLSLHQDGIRFASQGLEK--GEA-MNL 946

  Fly   911 PFLRVLKVFVPLLLVQDKTRIL 932
            .||.:|..|...||..::.::|
Zfish   947 QFLEILSEFSFKLLQPERKQLL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	27/134 (20%)
LOC100333021	XP_009305909.3	STAG	143..240	CDD:312124	25/107 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920