DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp10 and USP17L20

DIOPT Version :10

Sequence 1:NP_728554.1 Gene:Usp10 / 38103 FlyBaseID:FBgn0052479 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_001243790.1 Gene:USP17L20 / 100287441 HGNCID:44448 Length:530 Species:Homo sapiens


Alignment Length:474 Identity:112/474 - (23%)
Similarity:180/474 - (37%) Gaps:108/474 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1050 SYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRP----R 1110
            :::.....::|..||.|...:....:...||.:||          ..|.|..|:  |.||    .
Human    28 AFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQL----------APREKLPLS--SRRPAAVGA 80

  Fly  1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRL 1175
            ||.|..|.||:|:.||.|....|..|.:         ||...:.|.:.....|  ..::.:.:..
Human    81 GLQNMGNTCYVNASLQCLTYTPPLANYM---------LSREHSQTCHRHKGCM--LCTMQAHITR 134

  Fly  1176 RLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLND 1240
            .|:|             .|..:|...|.           :...| .|:||||.|||.:.::.:..
Human   135 ALHN-------------PGHVIQPSQAL-----------AAGFH-RGKQEDAHEFLMFTVDAMKK 174

  Fly  1241 EMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSR 1305
            ..|...|.:|                          :.:|.:         |.:..||.|..||:
Human   175 ACLPGHKQVD--------------------------HHSKDT---------TLIHQIFGGYWRSQ 204

  Fly  1306 LQREGEHS-TDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTL 1366
            ::....|. :|...|:..:.|:|:.|.||::|||.||..::|.|...   ....|...|.:.:||
Human   205 IKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

  Fly  1367 EKLPVVLILHLKYFDYRSDGC-TKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGK 1430
            .....||||.||.|   ||.. .||.|.|.:|..|.:...:   .:.:.....|.|:||:.|.|.
Human   270 HTSAKVLILVLKRF---SDVTGNKIAKNVQYPECLDMQPYM---SQPNTGPLVYVLYAVLVHAGW 328

  Fly  1431 EASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYY-RRSDTLPPQQQQTQQ 1494
            ....|||.:.| ......|.:.||:.|...|...||....    |:|:| ::|:    .::.::.
Human   329 SCHNGHYFSYV-KAQEGQWYKMDDAEVTASSITSVLSQQA----YVLFYIQKSE----WERHSES 384

  Fly  1495 QNGGGSGGVVGSSSSSSNA 1513
            .:.|.....:|:..:...|
Human   385 VSRGREPRALGAEDTDRRA 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp10NP_728554.1 UCH 1110..1479 CDD:425685 93/373 (25%)
USP17L20NP_001243790.1 Peptidase_C19E 79..373 CDD:239126 93/375 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..413 3/22 (14%)
HABP4_PAI-RBP1 <417..454 CDD:461421
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..530
Blue background indicates that the domain is not in the aligned region.

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