DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cep290 and cep290

DIOPT Version :10

Sequence 1:NP_612064.1 Gene:Cep290 / 38099 FlyBaseID:FBgn0035168 Length:1978 Species:Drosophila melanogaster
Sequence 2:XP_009296179.2 Gene:cep290 / 560588 ZFINID:ZDB-GENE-041111-243 Length:2741 Species:Danio rerio


Alignment Length:2532 Identity:519/2532 - (20%)
Similarity:963/2532 - (38%) Gaps:716/2532 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSMD----------IPETVSLRKFRDFSARQKQELY------ETLLELA--------ESIDELPK 41
            |.||          |.:.:.:.|.||..|...:::.      :|||.:.        |.:|....
Zfish    11 MGMDPEDLGDEDEKICDLILMVKPRDLKADDSEKMIQLFRISQTLLRMKLDEIKCAYEVVDSAGA 75

  Fly    42 KSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRR-LQDENEKLKRMLQKLEDERDGLKSKAK 105
            :..|...||...||:.:.| ::..|....||   |:. |:||..:|:..|::.|.|...|:   |
Zfish    76 EQARIENELKAKVLKLESE-LEMAQRVMGGG---DKHFLRDEIRQLESHLERKEKEVTQLE---K 133

  Fly   106 ELGEEIR---QLELRLQEAAQQAEISDKDSSDPLSELD-KQEQLLQNIDSKNK--------HIKR 158
            |:|:|.:   :|.||    |::||..::.....:.:|. |.|||.|:|:...|        ..|.
Zfish   134 EMGKERKSNEELALR----AEEAEEKNRKLKREIKQLTRKNEQLQQDIEFYRKEAEQRESLQTKE 194

  Fly   159 LLKEIE---TLQNQNIAQSKTIVLHEREL--------QTIKANLVQLSQDITKVEQERKSLKQKE 212
            ...||:   |..||.:.|....:.|..::        :.::.||.:..:::.|:..|...:|   
Zfish   195 ESNEIQRRLTKANQQLYQCMEELQHAEDMAANLRSENEHLQKNLEESVKEMEKMTDEYNKMK--- 256

  Fly   213 QQQALEITRLEGNLTFLEVEREKQEVEMRQFLDKYE--------------AKSLGWRQALDDRDK 263
                :.:.:.:..:..|..:|:..::::|:..|:.:              ||...|:..|..:|.
Zfish   257 ----IAVQQTDAIMDQLRKDRDHAKLQVRELTDQIQARVEEDDPVMAAVNAKVEEWKSVLSGKDL 317

  Fly   264 EV---ERLKKQLEGKSISSGQTNS--SNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEM 323
            |:   :::.:.|..| :.:.|.:|  ||..:.|:..: :|...::.|:.:|:.|.|:::....||
Zfish   318 EILEYQQMIRDLREK-LRTAQMDSDKSNIIALQQVIY-ELCGAVQERDNQIKMLSEQVEQYTTEM 380

  Fly   324 VSSTRAMNQLCQ--EKERAHDPEQPR------ACCQMIEERLREATARCQQLSEMLEAAEQDNVL 380
            ..:...:.:|.:  :|::.|..:..|      |..|:.|.::.|| .|..||:|. :|.::|..|
Zfish   381 ERNAMLIEELKRPLKKDKGHSSDHQRRLEDLSAKLQVAERKVLEA-QRAAQLAER-DARDKDKEL 443

  Fly   381 KSQQALHAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSL----HEVVQENE 441
            ..     .:|.:..|:...|||..|:......:.::..||:::...|:|:|.|    :.::.|||
Zfish   444 ND-----TLSRIRLYESGTDGLEAAISEIKECKNQIRVRDREIEGMIKEINQLEMKINNLLDENE 503

  Fly   442 LLRRKLHI-PDDVVIMAKNVHS---KQRNKD-------KQIERLTLKLRTSEELRLQLK------ 489
            .||.:|.: |.:.:.:::...|   |||...       |:||||       ||.||:||      
Zfish   504 DLRERLGLNPKEELDLSEFRRSKILKQRQYKAENQVLLKEIERL-------EEERLELKQRIRAL 561

  Fly   490 -------------LEKSELRRKLLELQQDSPQT------LNESLQAPSEVGEVPHSVHLENSPRR 535
                         |:.|...:.:..|:..|..|      .||.||  .|:......:.|..|   
Zfish   562 VKDKGVTVVSNSLLDNSVEEKPVRSLRPSSGSTDDEIKRKNERLQ--KELSNKEKELELRRS--- 621

  Fly   536 GQGDGAASSEMQNRYDEVLAENETLRSGMYEILEKLREYD---ATSEHITIDSDLLRRLIEAL-- 595
                  .|::.:.:.:|:|.||:.|..||.|||:.:::..   .||..::|.|  |.||:.||  
Zfish   622 ------ESAQFKAKLNEMLNENKQLEQGMKEILQAIQDTQKKTPTSTGVSIPS--LERLVNALEM 678

  Fly   596 ---PGGTTTPQRLQGQLLELKAREEALRQ------------------------LLEQQNYSDSET 633
               .|.......|:.|:.:|..|.|.|||                        .||::..|.|::
Zfish   679 KYSEGKFDASLHLRTQVDQLTGRNEELRQEMKTAREEAANTLSQLTKANEKIARLEREMESMSKS 743

  Fly   634 GELSSVHSLCEVPEIAEEHPVEEDAV--LNTAT-------------------------RPSSPTE 671
            ...|..|....:||  |..|...:|:  ||..|                         |..:...
Zfish   744 TGSSIPHKTLALPE--EMTPTSAEAINALNEYTVQLLQEIKNKGDSIEQLGSALEEYKRKFAVIR 806

  Fly   672 ATMGLRRPTVPDPEE--KPTNEALAEL-----------SILRKHYDELRLHMSADGSDLMNRNQE 723
            ...||.........|  :...::.|||           ::..|.|:.|...:..|.|::.....|
Zfish   807 HQQGLLYKEHQSERESWQKERDSFAELKSKLEEQREVDAVKIKEYNHLLETLEKDPSEIRREMAE 871

  Fly   724 LHDQMIALE-------------LQLEQQ-RNSYSYMRRDYDQL---LTETRKQELRFID----DK 767
            ...:::.|.             |:|||. |...:.::.|:.|:   :||......||.:    ..
Zfish   872 TGRKIVVLRVNEKCLTRRYTTLLELEQHLRKENAKLKEDFTQMQAVVTERIGYLQRFKEMAAFKM 936

  Fly   768 ASLAR----------------------------------------QLEHSKSELCEAREELEQVN 792
            |||.:                                        .|||.::|....||.::.:|
Zfish   937 ASLQKSLDVSVPASELERANKQYTELTIKYRNLLQKDNHLVQKTTSLEHLETENMSLRERIDSIN 1001

  Fly   793 ------RRNLYTAE-------------------------------------------EQQKLEHR 808
                  :..|:|.|                                           |:|:.|| 
Zfish  1002 KELEISKEKLHTLEQAFENISTTGGEIIMDKATKAVANSEIVSVSRRITTLEMKELNERQRAEH- 1065

  Fly   809 NAILSMQLGQAM-EQLLGELKPTEICAEYGIIRENYQLD---------YITAQDFE-EQQQELLT 862
                    .|.| |.|...||..|        ..|::|:         .:.||..| |.:.||..
Zfish  1066 --------AQKMYEHLRNSLKQVE--------ERNFELETKFAELTKLNLEAQRIERELRDELAD 1114

  Fly   863 WRSK----------------QAELQRETKQLEGLLHVANEQIHS----QQRLLNEITDNHINLRH 907
            ..||                :|.|:.|..:|..:..||..|:.:    ||....|:.    :||.
Zfish  1115 SVSKHISDADRKRITELEKTEANLRIEVSKLREVSDVAKMQVSALDARQQSREKEVE----SLRR 1175

  Fly   908 LVADLQSSSDEKLMLAKVQRDLDSVK----AECSRLETEREKLQLKADCLQTQLEASELSLKQTQ 968
            .|.|.|:.||||.::||:.:.:.:::    ...||||....:||.    |:.|....|..|.:.|
Zfish  1176 QVLDYQAESDEKALIAKLHQHIVALQLSETTAISRLEAANTRLQK----LEAQKLRDEQKLDEQQ 1236

  Fly   969 QDFQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQR---RLEEEQVQQRHRD 1030
            |.....|.....:.:.|:|::..|:.:::...||.       ..:||..   .|:|::.  |.|:
Zfish  1237 QALWHARQEGHQRARHLRHTIQALRRQFSGALPLA-------QQEKFSNTMLHLQEDRA--RVRE 1292

  Fly  1031 HTALIDEVTAVVQAKI--------GLNE--------ESSQQLVKLIKSETQTRLLEQRCEILQAK 1079
            ...:.:|.....:.|.        ||.|        :.:|::.:..|.....||||.|      :
Zfish  1293 DAQIAEEERRKAEGKAQELELKLKGLEELIATLKDAKGAQKVSEWHKKLEDVRLLEMR------Q 1351

  Fly  1080 QEELVRELGELRMSQATDTEHWSTI-----------------QALFGEGEPRSQLKVDAETNTDA 1127
            ..||..:..|::..:....|...||                 |.::.:.|.:.:.::|:......
Zfish  1352 SRELNTQKEEIKYLKNCVAEQERTISGLEEELVQQNNLLEERQLIWDQREVQLERQLDSYEKQQN 1416

  Fly  1128 VAPNLAMR--RAVQLIDRESSPIGSPL-------RKHPH--LDTAT--QTLEAQVEFSETAVQTN 1179
            ...|.|.:  .|...:...:.|:.:.|       ::|..  |:|.|  :.||.:::..|.|:.: 
Zfish  1417 EVLNTAQKFEEATGSLPDPNQPLANQLDYALGKIKEHVRTILETKTTCKILEEKLKEKEAALWS- 1480

  Fly  1180 GILSQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESASPQGGV 1244
               |:||  |.:.|.|          :.:::..|..|.:|.::|.   ..|:.|..|| .|...|
Zfish  1481 ---SEQN--VLSRDKV----------INELRLRLPAAAEREKLLA---NLSKQEDSES-QPTLKV 1526

  Fly  1245 VEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDAEI 1309
            ..:||.:....|.:|::.::|||:||...| |.|:.::|:  ..|.:||....|:..:.|.....
Zfish  1527 AHQTINNLQGRLDQKEEVLKKYQNLLGKAR-QEQEEIAKR--HEEEVRALHQKLDVYMDTSLDRF 1588

  Fly  1310 QGLKEKLRQKPEVPVERNPSTD--------SRSSSSSDSSVNELTDEKIEELFESSSVERPPQEE 1366
            :....:|.:||.:.|   |::.        .::.:..|:|::.|: :|::.:.:....:|  |..
Zfish  1589 KQTALELIKKPTITV---PTSKHLVRLAEMEQTVAEQDNSLSSLS-QKLKIVTQELDQQR--QVT 1647

  Fly  1367 LEVPVEAGPENIVTEEPEGEEEK---QDTEELK-EVPTLHKQIKDLKDKLEYSERS-----LKTR 1422
            ....:|...:....|:....:.|   |:.|||: ::..:.|::..|:.:||..:.:     ..|.
Zfish  1648 AAQAMEHAADMARLEDKHAAQMKGLSQEAEELRAQLIQMEKELHYLRTELEAQKEANVRSPSNTM 1712

  Fly  1423 EEEVDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEK----------------------DKHI 1465
            :..|:.||.:|.|   :||.::: ::..|.:||..|..:                      ||..
Zfish  1713 KNLVERLKNQLAL---KEKQLKA-LSKALLELRAELTSQAEQQIITNAAQKEEALNVQQIVDKQT 1773

  Fly  1466 KDLMDTLKNFHDDQQ------RYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLAN 1524
            |:|...:::.:::.|      |..|...|..::.:..|..||.|::.:.               |
Zfish  1774 KELRACVRDLNEELQLAKDGVRAAKARENSLKEDLETLNKDLQRSQKSQ---------------N 1823

  Fly  1525 VTQREKQARDLSQSLRQQLLKRPVVSIKTELNARVKNENQL-----KRIQQLELDLD--EARGQL 1582
            ..|.||:|  |.:.|.:  ||:.:..:.:.|.|:|:::...     |:|::||.:||  ......
Zfish  1824 KLQSEKEA--LEEHLNE--LKKKIQRLSSGLQAQVESDGPTVDSLQKKIRKLEHELDRKSISEPA 1884

  Fly  1583 QRQQTLLEAKRTRSANEVQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKD 1647
            .::.||.|.|  .|..||..||:.|::|.:.:|.:..|:|.|..::.....|...:...:|||::
Zfish  1885 DKRSTLKEDK--SSKEEVVRWEEGKKWQARVDKMRNVLKEKEREVDSQAKQLATMKELYSRLEQE 1947

  Fly  1648 KQILESKL-GRNGPPSNSSGGNNLKCCR------------------------TPSCPNLQHVGV- 1686
            |..|:.|| ||........|...|:..:                        .|....::.:.: 
Zfish  1948 KVSLQKKLKGRGVTADQVVGARTLEADKEIEELHKRNAELEQQIKVMKQQQALPRDAAMEDITIR 2012

  Fly  1687 ------------SKFAPSPSESPET--YTGPS------------------SECSSPAHHHTQIFD 1719
                        |:.:..|...|..  .|.||                  .:..|...:.|.:..
Zfish  2013 NRYLEERLYSMESRLSKEPPSRPSDRHSTSPSQLSWSSKVRSMTFDVIEAEQTQSSLLNSTVVVT 2077

  Fly  1720 QSQLDLIE------------------------ALKSRIELQQRKIIAME-LEGRGSNALTTELEK 1759
            :.::.:||                        ..|:.::|:|:.::..: .|.:.:|.....:||
Zfish  2078 EKEISVIEDKPTQTSFRSIDMGTAEVNQDDENVAKNEVDLEQKALMKDDKTEQKENNKEKGSVEK 2142

  Fly  1760 LQERCQAIE-AQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRE 1823
            .:|:....: .|::.:      .:...:.|:..|.:::|:..:.|.|.....|.|:....|:...
Zfish  2143 DEEQPDDTQRGQDVAV------FEYAQEELKTNDEAEQLESELTHREMMEKPLDEDQLEVENEET 2201

  Fly  1824 LGSGLKVST-NQGQ-----------------------------------SAEQTILSLRNLVE-K 1851
            ....:..|| ||.:                                   ..|:|.||.....: |
Zfish  2202 NAEEMLYSTMNQAELETPKVLLEGDEDYGQEPEELLKCECDPSAESKELDEEETALSNSTTFDAK 2266

  Fly  1852 LRSENKFLKDGRRSTE----SRSSMDSTPAEAARLQQQ-----HAEALEKISALQQELQKRTTKC 1907
            |.||...::..:..|.    :.:..:.:|:.......:     |.:|  |::.|..:.....:|.
Zfish  2267 LVSEQPAMEKNKSFTPEAGFNPNLSEVSPSRELNANTENDILGHLKA--KVTRLNDKEHSMKSKA 2329

  Fly  1908 SQCGGRSKDAANE-ELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQLALWKRKCSELQ 1968
            .:..||..|..:: |.:|.||.|...|:.|: .:..|.:|......|::|::..|..||.|:
Zfish  2330 RKTSGRGSDTPSQREHEFQKENLRLSTENLE-LRFQLEQANKDLPRLKDQVSDLKEMCSVLK 2390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep290NP_612064.1 Smc <11..>524 CDD:440809 142/617 (23%)
SMC_prok_B <839..>1092 CDD:274008 70/305 (23%)
Smc <854..>1413 CDD:440809 139/644 (22%)
GumC <1477..>1655 CDD:442439 47/190 (25%)
YhaN 1492..>1899 CDD:443752 95/543 (17%)
cep290XP_009296179.2 None

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