Protein Alignment Cep290 and Cep290

DIOPT Version :10

• Sequence 1: NP_612064.1
• Gene: Cep290 / 38099
• FlyBaseID: FBgn0035168
• Length: 1978
• Species: Drosophila melanogaster
• Sequence 2: NP_001387932.1
• Gene: Cep290 / 314787
• RGDID: 1311640
• Length: 2763
• Species: Rattus norvegicus
• Alignment Length: 2751
• Identity: 509/2751 - (18%)
• Similarity: 993/2751 - (36%)
• Gaps: 956/2751 - (34%)

  Fly    20 RQKQELYETLLELAE-SIDELPKKSLRKTLEL---TLAVLEYKGEQVQ-QLQESAAGGLSSDRRL 79
            ||::...:.|:.|:: .::||..:.....:.|   |.::::.|.::|: .|:|....|   :.:.
  Rat    20 RQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAG---EEQA 81

  Fly    80 QDENEKLKRMLQKLEDERDGLKSKA-----KELGEEIRQLELRLQEAAQQAEISDKDSSDPLSEL 139
            :.||: ||..:.|||:|.:..:..|     :.|.:||||||       :|.|..|::..|...||
  Rat    82 KFENQ-LKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLE-------KQLEQKDRELEDMEKEL 138

  Fly   140 DKQ----EQL-LQNIDSKNKHIKRLLKEIETLQNQNIAQSKTIVLHERELQTIKANLV------- 192
            ||:    ||| |:|.:::|::.| |.:|.:.|:.:|....:.|:.:::::.:.|.:|:
  Rat   139 DKEKKVNEQLALRNEEAENENSK-LRRENKRLKKKNEQLRQDIIDYQKQIDSQKESLLSRRGEDS 202

  Fly   193 ----QLS-------------QDIT----KVEQERKSLKQKEQQQALEITRL--EGN--------- 225
                |||             |.:|    |:|.:.:.:::..::...|:.::  |.|
  Rat   203 DYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQT 267

  Fly   226 ---LTFLEVEREKQEVEMRQFLDKYEAKS--------------LGWRQALDDRDKEV---ERLKK 270
               :..::.|.|...:::|:..|..:||.              ..|:..|..:|.|:   :::.:
  Rat   268 DTVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQ 332

  Fly   271 QLEGKSISSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAM----N 331
            .|.|| :.:.|.::..|...      .|:|.::.|:.:|:.|.|:::...:||..:|..:    |
  Rat   333 SLRGK-LKNAQLDADKSNIM------ALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKN 390

  Fly   332 QLCQEKERAHDPEQP-----RACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISA 391
            :|.::|..::..:|.     .:..|::||:.:||    ::.:|:.||..::   |.::.:.|:..
  Rat   391 ELRKDKGTSNIYQQTHYMKIHSKVQILEEKTKEA----ERTAELAEADARE---KDKELVEALKR 448

  Fly   392 LEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSL----HEVVQENELLRRKLHIPDD 452
            |:.|:....||..|:......:.::..||.::....:|:|.|    ::|:.|||.||.:..:...
  Rat   449 LKDYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERAGLEPK 513

  Fly   453 VVI------MAKNVHSKQRNKDKQI----------ERLTLKLR---------------------- 479
            .:|      .:|.|..:|...:.||          |||.||.:
  Rat   514 TMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGKRSAASGLTIDDL 578

  Fly   480 --------------------------------------------------------TSEELR--- 485
                                                                    |.|.|.
  Rat   579 NLTETFSHGDKIGERKLNFISFNNMNETQSKITSSANTELLHRRPSFSVVQSDRSETEENLTTRS 643

  Fly   486 ----------------------------LQLK-------------LEKSELRRKLLELQ------ 503
                                        :|||             :.|:...|.|..|:
  Rat   644 LSRMLSGIHHSVDSAVEPVVSLTRCSSFMQLKDSNTTPEAITIREIFKAPCLRSLRNLESLVSTF 708

  Fly   504 -QDSPQTLNESL----------------------------------------------------- 514
             :||.:.|:|.|
  Rat   709 SKDSSEELSEYLCSLSDDCVKRGSGNHRALEKTRFLQKRSSSFPASPIAAELMQRYSHRQSSAVF 773

  Fly   515 -----------------QAPSEV--------------------------------GEVP------ 524
                             ||.|::                                |.||
  Rat   774 PQQSYAHEVHKVTSEGDQAHSQIKYADLSLKDNKRQSESSSQTEMSRSKSQINLSGLVPVIAQSR 838

  Fly   525 ---------------------------------------HSVHLENSPRRGQGD----------- 539
                                                   .:.||:...:|.|.:
  Rat   839 ASLVHPREKLLGQLQRELVLLRSQNETIAQDLSIQEEQSRNAHLDLDHQRSQEEQNEFLSRELIE 903

  Fly   540 --------GAASSEMQNRYDEVLAENETLRSGMYEILEKLREYDATSEHITIDSDL----LRRLI 592
                    ....::.||:..|::.||:.|..||.|||:.:::....|:....::.|    |.||:
  Rat   904 KEKDLERSRTVITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLV 968

  Fly   593 EAL-----PGGTTTPQRLQGQLLELKAREEALRQLL-----EQQNYS-------------DSETG 634
            .|:     .|.......|:.|:.:|..|.|.|||.|     |..|||             :.||.
  Rat   969 NAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEKETD 1033

  Fly   635 ELSS--------------------------------VHSLCEVPE-------------------- 647
            .|..                                :|.|.|:..
  Rat  1034 LLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFA 1098

  Fly   648 --------------------------IAE-----EHPVEEDAV--------LNTATRPSSPTEAT 673
                                      |.|     |...::|||        ||.....|:..:..
  Rat  1099 VIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEYNNLLNALQMDSNEMKKM 1163

  Fly   674 M--GLRRPTVPDPEEKPTNEALAELSILR-----------------KHYDELRLHMSADGSDLMN 719
            :  ..|:.||....||         |::|                 ||.::: :.|.|:.::.:.
  Rat  1164 LSENSRKITVLQVNEK---------SLIRQYTTLVEIERQLRKENGKHKNDV-ISMEAEVTEKIG 1218

  Fly   720 R--------------NQELHDQMIALELQLEQQRNSYSYMRRDY------DQLLTETRKQELRFI 764
            .              .|::.|..::|. :||.....||.:...|      |.:|.:.........
  Rat  1219 NLQRFKEMATFRIAALQKVVDNSVSLS-ELELANKQYSELTAKYRDVLQKDNMLVQRASNLEHLA 1282

  Fly   765 DDKASLARQLEHSKSELCEAREELEQV-----------NRRNLYTAE------------------ 800
            .:.|||..|:|....||...:|:|..:           |..|:..|:
  Rat  1283 CENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLGNESNMDKAKKSMTNSDIVSISKKITVL 1347

  Fly   801 ------EQQKLEHRNAILSMQLGQAMEQLLGELKPTEICAEYGIIRENYQLD---------YITA 850
                  |:|:.||        ..:..|.|...||..|        ..|::|:         .:.|
  Rat  1348 EMKELNERQRAEH--------CQKMYEHLRTSLKHME--------ERNFELETKFTELTKINLDA 1396

  Fly   851 QDFEE-----------------QQQELLTWRSKQAELQRETKQLEGLLHVANEQI---HSQQRLL 895
            |..|:                 .:|.:|....::.||:.|..:|..:..:|..|:   :|||:..
  Rat  1397 QKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVEVSKLREISDIAKRQVDFLNSQQQSR 1461

  Fly   896 NEITDNHINLRHLVADLQSSSDEKLMLAKVQRDLDSVK----AECSRLETEREKLQLKADCLQTQ 956
            .:..:   :||..:.|.|:.||||.::||:.:.:.|::    ....:||:...|||        :
  Rat  1462 EKEVE---SLRMQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQ--------K 1515

  Fly   957 LEASELSLKQTQQDFQQ----ERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQR 1017
            :||..|.|:|...:.:|    .|.....:...|:.::..|:.:::...||.       ..:||.:
  Rat  1516 MEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTIQSLRRQFSGALPLA-------QQEKFSK 1573

  Fly  1018 RL------------EEEQVQQRHRDHTALIDEVTAVVQAKI-GLNEESSQQLVKLIKS------- 1062
            .:            |.:..||.||:    ::..|..::.|: ||.|     |:..:|.
  Rat  1574 TMIQLQNDKLKIMQEMKNSQQEHRN----MENKTLEMELKLKGLEE-----LISTLKDARGAQKV 1629

  Fly  1063 -ETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTD 1126
             ....::.|.|.:.|:..: |||:...|::......:|:..||.:|  |.:...|.|...|....
  Rat  1630 INWHVKIEELRLQELKLNR-ELVKGKEEIKYLNNIISEYEHTISSL--EEDIVQQSKFHEERQMA 1691

  Fly  1127 AVAPNLAMRRAVQLIDRESSPIGSPLRKHPHLDTATQT-------LEAQVEFSETAVQTNGILSQ 1184
            .....:.:.|.:.:.||:.:.|.|..:|   .:.||.:       |..|:|.:...::.|..:..
  Rat  1692 WDQREVELERQLDIFDRQQNEILSAAQK---FEDATGSMPDPSLPLPNQLEIALRKIKENIQIIL 1753

  Fly  1185 QNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQL-----------EASRSESRESA 1238
            :.||  |..::|:..::..:.|:..::.:...::.|..|..||           |.:|:|....:
  Rat  1754 KTQA--TCKSLEEKLKEKESALRLAEQNILSRDKVINELRLQLPATADREKLIAELNRTELEPKS 1816

  Fly  1239 SPQGGVVEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSK-------------QVAEN-- 1288
            .....:..:||.:....|..|::.::|||.||:..|::.::.:.|             |.|:|
  Rat  1817 HHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSL 1881

  Fly  1289 ESLRATVNNLNFNIKTKDAEIQGLKE--KLRQKPEVPVERNPSTDS-----RSSSSSDSSVNELT 1346
            ...:.|..:|   ||...|.:...|.  :|.:..:...|::.|..|     :..|.......|:|
  Rat  1882 SKFKQTAQDL---IKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVT 1943

  Fly  1347 DEKIEELFESSSVERPPQEELEV-PVEAGPEN----IVTEEPEGEEEKQDTEELKE----VPTLH 1402
            :.|:.| ||::.:........|| .|:|..|:    :...:.:.:..|.:.:..||    .||
  Rat  1944 EFKVRE-FETTKLRLQETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPT-- 2005

  Fly  1403 KQIKDLKDKLEYSERSLKTREEE------VDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEK 1461
            ..:::|.|:|: |:.:||.::::      :::..|.....:||..:|.|.....|:..::.
  Rat  2006 TTMRNLVDRLK-SQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVV---- 2065

  Fly  1462 DKHIKDLMDTLKNFHDDQQRYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVT 1526
            ::|.|:|...:::.:::..: :|:....|:::...||.|||  :..|::...|      :..|..
  Rat  2066 ERHTKELKSQIEDLNENLLK-LKEALKTSKNKENSLADDLN--DLNNELQKKQ------KAYNKI 2121

  Fly  1527 QREKQARDL-SQSLRQQLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLE 1590
            .|||...|. :..||:| :||    :.:.|.::...:|:...|.:|:..:.:...||:||...::
  Rat  2122 LREKDGIDQENDELRRQ-IKR----LSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVD 2181

  Fly  1591 AK--RTRSANEVQL-WEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILE 1652
            .|  :.:|..|..: ||:.|::|.:.|..:.:|:|.|..:......|...:...|:.:|:|..|:
  Rat  2182 IKPIKEKSGKEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQ 2246

  Fly  1653 SKLGRNGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQI 1717
            .||...|...:                  |.:|| :...|..|..|
  Rat  2247 KKLKTTGMTVD------------------QVLGV-RALESEKELEE------------------- 2273

  Fly  1718 FDQSQLDL------------------IEALKSRIELQQRKIIAME---LEGRGSNALTTELEKLQ 1761
            ..:..|||                  :|.|..:....|.|:..:|   .:...|.:||:|:|. .
  Rat  2274 LKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQNRYLQEKLHTLENKLSKDAYSQSLTSEIES-D 2337

  Fly  1762 ERC---QAIEAQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRE 1823
            :.|   |.::.:|::|.:.|::|:...:..::  ...||:.:::.|::....||:  .:.|..|:
  Rat  2338 DHCQKEQELQRENLKLSSENIELKFQLEQAKK--DLPRLKNQVRDLKEMCEILKK--GKMELERK 2398

  Fly  1824 LGSGLKVSTNQGQS---AEQTILSLRNLVEKLRSENKFLK--DGRRSTESRSSMD----STPAEA 1879
            ||. ::.|...|::   .|:||..::.:|||::.||:.||  .|..::|..::::    ...||.
  Rat  2399 LGQ-VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAEL 2462

  Fly  1880 ARLQ-----------QQHAEALEKISALQQELQKRTTKCSQCGGRSKDAANE------------- 1920
            .:|:           :..::..|:|.|..:.|:|...|..|...:.:.|.|.
  Rat  2463 EKLKAHFGRQLSMQFESKSKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLE 2527

  Fly  1921 -----------------------------------ELKFIKEQLVKKTQLLQKAKVLLTRAAAKE 1950
                                               ::|.::..:.||.|.:...|.|:..|..:|
  Rat  2528 ETGKRLQFAESRGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATERE 2592

  Fly  1951 KVLREQLALWKRKCSELQNVP 1971
            :..::.....:::...|:|||
  Rat  2593 QKAKKYTEDLEQQIEILKNVP 2613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep290	NP_612064.1	Smc	<11..>524	CDD:440809	145/837 (17%)
		SMC_prok_B	<839..>1092	CDD:274008	64/310 (21%)
		Smc	<854..>1413	CDD:440809	135/656 (21%)
		GumC	<1477..>1655	CDD:442439	43/181 (24%)
		YhaN	1492..>1899	CDD:443752	98/454 (22%)
Cep290	NP_001387932.1	SMC_prok_B	17..>564	CDD:274008	157/941 (17%)
		SMC_prok_B	<804..1555	CDD:274008	178/864 (21%)
		SMC_prok_B	1367..2142	CDD:274008	143/716 (20%)
		CEP209_CC5	1574..1701	CDD:465184	29/129 (22%)
		Smc	<1907..>2436	CDD:440809	15/113 (13%)
		PRK03918	2493..>2738	CDD:235175