Protein Alignment Cep290 and Cep290

DIOPT Version :10

• Sequence 1: NP_612064.1
• Gene: Cep290 / 38099
• FlyBaseID: FBgn0035168
• Length: 1978
• Species: Drosophila melanogaster
• Sequence 2: NP_001387926.1
• Gene: Cep290 / 216274
• MGIID: 2384917
• Length: 2763
• Species: Mus musculus
• Alignment Length: 2751
• Identity: 512/2751 - (18%)
• Similarity: 991/2751 - (36%)
• Gaps: 956/2751 - (34%)

  Fly    20 RQKQELYETLLELAE-SIDELPKKSLRKTLEL---TLAVLEYKGEQVQ-QLQESAAGGLSSDRRL 79
            ||::...:.|:.|:: .::||..:.....:.|   |.::::.|.::|: .|:|....|   :.:.
Mouse    20 RQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAG---EEQA 81

  Fly    80 QDENEKLKRMLQKLEDERDGLKSKA-----KELGEEIRQLELRLQEAAQQAEISDKDSSDPLSEL 139
            :.||: ||..:.|||:|.:..:..|     :.|.:||||||       :|.|..|::..|...||
Mouse    82 KFENQ-LKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLE-------KQLEQKDRELEDMEKEL 138

  Fly   140 DKQ----EQL-LQNIDSKNKHIKRLLKEIETLQNQNIAQSKTIVLHERELQTIKANLV------- 192
            ||:    ||| |:|.:::|::.| |.:|.:.|:.:|....:.|:.:::::.:.|.:|:
Mouse   139 DKEKKVNEQLALRNEEAENENSK-LRRENKRLKKKNEQLRQDIIDYQKQIDSQKESLLSRRGEDS 202

  Fly   193 ----QLS-------------QDIT----KVEQERKSLKQKEQQQALEITRL-------------- 222
                |||             |.:|    |:|.:.:.:::..::...|:.::
Mouse   203 DYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQS 267

  Fly   223 EGNLTFLEVEREKQEVEMRQFLDKYEAKS--------------LGWRQALDDRDKEV---ERLKK 270
            :..:..::.|.|...:::|:..|..:||.              ..|:..|..:|.|:   :::.:
Mouse   268 DAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQ 332

  Fly   271 QLEGKSISSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAM----N 331
            .|.|| :.:.|.::..|...      .|:|.::.|:.:|:.|.|:::...:||..:|..:    |
Mouse   333 SLRGK-LKNAQLDADKSNIM------ALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKN 390

  Fly   332 QLCQEKERAHDPEQP-----RACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISA 391
            :|.::|..::..:|.     .:..|::||:.:||    ::::|:.||..::   |.::.:.|:..
Mouse   391 ELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEA----ERIAELAEADARE---KDKELVEALKR 448

  Fly   392 LEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSL----HEVVQENELLRRKLHIPDD 452
            |:.|:....||..|:......:.::..||.::....:|:|.|    ::::.|||.||.:..:...
Mouse   449 LKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPK 513

  Fly   453 VVIMAKNVHSKQRNKDKQI----------------ERLTLK-----------------------L 478
            .:|......:.:|.|.:|.                |||.||                       |
Mouse   514 TMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGLTIDDL 578

  Fly   479 RTSEELRLQLKLE-------------------KSELRRKLLE-------LQQDSPQ--------- 508
            ..||....:.|:|                   ||..:.:||.       :|.|..:
Mouse   579 NLSETFSHENKIEGRKLNFMSLNNMNETQSKIKSSAKTELLHRRPSFSVVQSDQSEAEENMATRS 643

  Fly   509 -----------------------------------------TLNESLQAP--------------- 517
                                                     |:.|..:||
Mouse   644 LSRMLSGIHQSVGSAGDPIVSLTRCSSFMQVKDSSATPEAITIREIFKAPCLRSLRKLESLVSTF 708

  Fly   518 -----SEVGE------------------------------------------------------- 522
                 .|:.|
Mouse   709 SKDGSEELSEYLCSLSDDHMKRGSGNHRGLEKTRFLQKSSSSFQVSPAAAELMQKLSHRQSSAIF 773

  Fly   523 ----------------------VPHSVHLENSPRRGQGDGAASSEM------------------- 546
                                  :.|:| |.....:||.:..:.:||
Mouse   774 PQQSYDRDVDKVTSEDNQVYSQIEHAV-LSLKDDKGQSELPSQTEMLSSKTQVNLSDLVPITAQS 837

  Fly   547 ----------------------------------------------------------------- 546
                                                                             
Mouse   838 KPSLIHPLEKLIGQPQRQLAFLRSQNETIVQDLPIQEEQSRNAELELDHQRSQAEQNEFLSRELA 902

  Fly   547 ----------------QNRYDEVLAENETLRSGMYEILEKLREYDATSE------HITIDSDLLR 589
                            |::..|::.||:.|..||.|||:.:::....|:      .:.|.|  |.
Mouse   903 EKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPS--LE 965

  Fly   590 RLIEAL-----PGGTTTPQRLQGQLLELKAREEALRQLLEQQ-----NYS-------------DS 631
            ||:.|:     .|.......|:.|:.:|..|.|.|||.|.|.     |||             :.
Mouse   966 RLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEK 1030

  Fly   632 ETGELSS--------------------------------VHSLCEVPE----------------- 647
            ||..|..                                :|.|.|:..
Mouse  1031 ETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNR 1095

  Fly   648 -----------------------------IAE-----EHPVEEDAV-------LNTATRPSSPTE 671
                                         |.|     |...|:|||       |.:|.:..|...
Mouse  1096 KFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEM 1160

  Fly   672 ATM---GLRRPTVPDPEEKPTNEALAELSILRKHYD--ELRLHMSADGSDLMNRN---------- 721
            ..|   ..|:.||....||         |::|::..  |:..|:..:..  .:||
Mouse  1161 KKMLSENSRKITVLQVNEK---------SLIRQYTTLVEMERHLRKENG--KHRNDVIAMEAEVT 1214

  Fly   722 --------------------QELHDQMIAL-ELQL-EQQRNSYSYMRRDY---DQLLTETRKQEL 761
                                |::.|..::| ||:| .:|.|..:...||.   |.:|.: |...|
Mouse  1215 EKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQ-RTSNL 1278

  Fly   762 RFID-DKASLARQLEHSKSELCEAREELEQV-----------NRRNLYTAE-------------- 800
            ..:: :.|||..|:|....||...:|:|..:           |..|:..|:
Mouse  1279 EHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKK 1343

  Fly   801 ----------EQQKLEH--------RNAILSM-QLGQAMEQLLGELKPTEICAE--YGIIRENYQ 844
                      |:|:.||        |.::..| :....:|....||....:.|:  ..::|:..
Mouse  1344 ITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDEL- 1407

  Fly   845 LDYITAQDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQI---HSQQRLLNEITDNHINLR 906
            .|.:|....:..:|.:|.....:.||:.|..:|..:..:|..|:   :|||:...:..:   :||
Mouse  1408 ADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVE---SLR 1469

  Fly   907 HLVADLQSSSDEKLMLAKVQRDLDSVK----AECSRLETEREKLQLKADCLQTQLEASELSLKQT 967
            ..:.|.|:.||||.::||:.:.:.|::    ....:||:...|||        ::||..|.|:|.
Mouse  1470 TQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQ--------KMEAYNLRLEQK 1526

  Fly   968 QQDFQQ----ERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRL--------- 1019
            ..:.:|    .|.....:.|.|:.::..|:.:::...||.       ..:||.:.:
Mouse  1527 LDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLA-------QQEKFSKTMIQLQNDKLK 1584

  Fly  1020 ---EEEQVQQRHRDHTALIDEVTAVVQAKI-GLNEESSQQLVKLIKS--------ETQTRLLEQR 1072
               |.:..||.||:    ::..|..::.|: ||.|     |:..:|.        ....::.|.|
Mouse  1585 IMQEMKNSQQEHRN----MENKTLELELKLKGLEE-----LISTLKDARGAQKVINWHVKIEELR 1640

  Fly  1073 CEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAPNLAMRRA 1137
            .:.|:..: |||:...|::......:|:..||.:|  |.|...|.|...|.........:.:.|.
Mouse  1641 LQELKLNR-ELVKGKEEIKYLNNIISEYEHTINSL--EEEIVQQSKFHEERQMAWDQREVELERQ 1702

  Fly  1138 VQLIDRESSPIGSPLRKHP----HLDTATQTLEAQVEFSETAVQTNGILSQQNQAVQTADAVEDN 1198
            :.:.|.:.:.|.|..:|..    .:...:..|..|:|.:...::.|..:..:.||  |..::|:.
Mouse  1703 LDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLEIALRKIKENIQVILKTQA--TCKSLEEK 1765

  Fly  1199 RRDSRAELQKMQETLQEANQRIEILGKQLEASRSE-------SRESASPQG----GVVEKTILSF 1252
            .::..:.|:..::.:...::.|..|..:|.|:...       .|:...|:.    .:..:||.:.
Mouse  1766 LKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMKIAHQTIANM 1830

  Fly  1253 HTLLLEKDQSIQKYQDLLQTERDQSQQALSK-------------QVAEN--ESLRATVNNLNFNI 1302
            ...|..|::.::|||.||:..|::.::.:.|             |.|:|  ...|.|..:|   :
Mouse  1831 QARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDL---L 1892

  Fly  1303 KTKDAEIQGLKE--KLRQKPEVPVERNPSTDS-----RSSSSSDSSVNELTDEKIEELFESSSVE 1360
            |...|.:...|.  :|.:..:...|::.|..|     :..|.......|:|:.|:.| ||::.:.
Mouse  1893 KQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVRE-FENTKLR 1956

  Fly  1361 RPPQEELEVPVEAGPENIVTEEPEGEEEKQDTEELKE-VPTLHKQIKDLKDKLE-----YSERSL 1419
            .  ||              |...|.::.|.:.|:|:. :...||..:.||.:|:     .|....
Mouse  1957 L--QE--------------THASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPT 2005

  Fly  1420 KTREEEVDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEK------------------DKHIK 1466
            .|....||.||.:|.|.::::|::...:.....::....:|:                  ::|.:
Mouse  2006 TTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTR 2070

  Fly  1467 DLMDTLKNFHDDQQRYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQ 1531
            :|...:::.:::..: :|:....|:::...||.|||  |..|::...|      :..|...|||.
Mouse  2071 ELKSQIEDLNENLLK-LKEALKTSKNKENSLADDLN--ELNNELQKKQ------KAYNKILREKD 2126

  Fly  1532 ARDL-SQSLRQQLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTR 1595
            ..|. :..||:| :||    :.:.|.::...:|:...|.:|:..:.:...||:|:...::.|..:
Mouse  2127 GIDQENDELRRQ-IKR----LSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVK 2186

  Fly  1596 ---SANEVQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGR 1657
               |..|:..||:.|::|.:.|..:.||:|.|.........|...:...|:.:|:|..|:.||..
Mouse  2187 EKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKT 2251

  Fly  1658 NGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQSQ 1722
            .|...:                  |.:|| :...|..|..|                   ..:..
Mouse  2252 TGMTVD------------------QVLGV-RALESEKELEE-------------------LKKKN 2278

  Fly  1723 LDL------------------IEALKSRIELQQRKIIAME---LEGRGSNALTTELEKLQERC-- 1764
            |||                  :|.|..:.:..|.|:..:|   .:.:.|.:||:|:|. .:.|
Mouse  2279 LDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIES-DDHCQK 2342

  Fly  1765 -QAIEAQNIRLEARNLQL-----QLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRE 1823
             |.::.:|::|.:.|::|     |.:.||       .||:.::|.|::....||:  .:.|..|:
Mouse  2343 EQELQKENLKLSSENIELKFQLEQANKDL-------PRLKNQVKDLKEMCEFLKK--GKLELERK 2398

  Fly  1824 LGSGLKVSTNQGQS---AEQTILSLRNLVEKLRSENKFLKD------------------------ 1861
            ||. ::.:...|::   .|:||..::.:|||::.||:.||.
Mouse  2399 LGQ-VRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAEL 2462

  Fly  1862 -------GRRST---ESRS-SMDSTPAEAARLQQQ---HAEALEKISALQQELQ----KRTTKCS 1908
                   ||:.:   ||:: ..:...||..||:::   ..||.||:...:..|:    |...:..
Mouse  2463 EKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLE 2527

  Fly  1909 QCGGRSKDAANE-----------------------ELKFIKEQLVKKTQLLQKAKVLLTRAAAKE 1950
            :.|.|.:.|.:.                       ::|.::..:.||.|.:...|.|:..|..:|
Mouse  2528 ETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATERE 2592

  Fly  1951 KVLREQLALWKRKCSELQNVP 1971
            :..::.....:::...|:|||
Mouse  2593 QKAKKYTEDLEQQIEILKNVP 2613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep290	NP_612064.1	Smc	<11..>524	CDD:440809	138/802 (17%)
		SMC_prok_B	<839..>1092	CDD:274008	63/284 (22%)
		Smc	<854..>1413	CDD:440809	131/628 (21%)
		GumC	<1477..>1655	CDD:442439	44/181 (24%)
		YhaN	1492..>1899	CDD:443752	106/480 (22%)
Cep290	NP_001387926.1	SMC_prok_B	28..>564	CDD:274008	148/934 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..164		15/40 (38%)
		SMC_prok_B	<853..1560	CDD:274008	165/800 (21%)
		SMC_prok_B	1367..2142	CDD:274008	147/730 (20%)
		CEP209_CC5	1574..1701	CDD:465184	29/129 (22%)
		SMC_prok_B	1908..2625	CDD:274008	15/87 (17%)