Protein Alignment Sf3b3 and RSE1

DIOPT Version :10

• Sequence 1: NP_728546.1
• Gene: Sf3b3 / 38093
• FlyBaseID: FBgn0035162
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_013663.1
• Gene: RSE1 / 854956
• SGDID: S000004513
• Length: 1361
• Species: Saccharomyces cerevisiae
• Alignment Length: 1422
• Identity: 350/1422 - (24%)
• Similarity: 600/1422 - (42%)
• Gaps: 316/1422 - (22%)

  Fly     1 MYLYNLTLQKATGVTHAVHGNF----SGGKQQEVLLSRGKSLELLRPDSNTGKVHTLLSTE-IFG 60
            :|||:|||:|.|...|:..|:|    :|.|:::..|.......|...|:..|::..:...: :|.
Yeast    58 LYLYHLTLKKQTNFVHSCIGHFVDLEAGSKREQSQLCVATETHLELYDTADGELKLIAKFQNLFA 122

  Fly    61 CVRALMAFRLT-GGTK-------DYIVVGSDSGRIVILEYNPSKNA--LEKVHQETFGKSGCRRI 115
            .:.::.:..|. .|::       .::.:.||||.:.|::......|  |:.:..:...::..||:
Yeast   123 TITSMKSLDLPHSGSRAKASNWPTFLALTSDSGNLSIVQIIMHAGALRLKTLVNQPLTRTTLRRV 187

  Fly   116 VPGQYFAIDPKGRAVMIGAVEKQKLAYIMNRDTQARLTISSPLEAHKSNTLTYHMVGVDVGFDNP 180
            .|..|..|||.||.:::.:||:.||.:::  |...:|.||||||..:.:.:|..|..|||.|:||
Yeast   188 SPISYMEIDPNGRCIILSSVEQNKLCFLV--DYAQKLRISSPLEIIRPHMVTLDMAVVDVNFNNP 250

  Fly   181 MFACLEIDYEEADMDPSGDAAQRTQQTLTFYELDLGLNHVVRKYSEPLEEHANFLVSVP------ 239
            .|..||||          :||.:....|.||.|:|||||:|:|....:...|||::|:|
Yeast   251 CFVTLEID----------NAATQLSVHLIFYVLELGLNHIVKKADYLVNPSANFVLSLPDLSRYN 305

  Fly   240 -----GGNDGPSG--------VLICSENYLTYKNLGDQHDIRCPIPRRRNDLDDPERGMIFICSA 291
                 ..|:..:.        |:|..||::..|::.....::..|| :|:..:...:.:..|...
Yeast   306 ITTSLSDNNYDADYDTLFNPFVVIGFENHILVKDMNGFFSLKVEIP-KRSITNSRHKNVTIISGI 369

  Fly   292 THRTKSMYFFLLQTEQGDIFKITL--ETDDDVVSEIKLKYFDTVPPATAMCVLKTGFLFVASEFG 354
            ..:.|:.:|.|||:..||:||:|:  :|:|.....::|.||||:..:..:.:.|.|:||..||..
Yeast   370 VQKLKNDFFVLLQSNHGDLFKLTVSPDTNDRNRPLVQLSYFDTIQNSHQLHIFKNGYLFALSEMN 434

  Fly   355 NHYLYQIAHLGDDDDEPEFSSAMPLEE-GETFFFAPR-ALKNLVLVDELPSFAPIITSQVADLAN 417
            |::|:|...||.:.:  :||:.:..:: .::..|.|. .|:||.::.:..:..|.|.||:.
Yeast   435 NNFLFQFEKLGVEKN--DFSNVLTSKDPNKSLVFEPSIKLQNLSILSQQLNLNPSIKSQIV---- 493

  Fly   418 EDTPQLYVLCGRGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWTVKKRA-DDEFDAYIIVSFVNA 481
            .|:| |.:.......:.:..|.:.:..|.:..:.||.|...:|.:...| ..:.:..:.::|...
Yeast   494 SDSP-LSIATKHFTNNKIITLTNAVNYSNLISTSLPPNATKLWLIPDPATTGDNNTLLFITFPKK 557

  Fly   482 TLVLSI-GETVEEVTD-----SGF-LGTTPTLCCAALGDDALVQVYPDGIRHI------RSDKRV 533
            |::|.| .|::||:|.     |.| |....|:....:|..:::||....:|||      |...::
Yeast   558 TMILQIDNESMEELTPDEATRSAFKLSQDTTIHTCLMGSHSIIQVCTAELRHIVPTGKSRYSNKL 622

  Fly   534 NEWKAPGKKSITKCAVNQRQVVITLSGRELVYFEMDPTG----ELNEYTERSEMPAEIMCMALGT 594
            . |..|....|.....::.|::|:||..|||||::|.:.    ||..:.|...||:::      .
Yeast   623 T-WVPPAGIRIVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELTTHPELDTMPSKV------A 680

  Fly   595 VPEGEQRSWFLAVGLADNTVRILSL--DPNNCLTPCSMQALPSPAESLCLVEMGHTESTTQGGLD 657
            :.:..|.:..||:...:..::|:||  ...:.||..|:|.:......:.:|.
Yeast   681 IVQDTQHADLLAIADNEGMIKIMSLKDQKEDFLTVISLQLVSEKISDMIMVR------------- 732

  Fly   658 DDAPAQRSGNNKGTIYLNIGLSNGVLLRTVLDPVSGDLADTRTRYLGSRPVKLF----------- 711
                    .::.|.:.|::||.|||.::..:..|.|...|.:.|:||.:||.|.
Yeast   733 --------DSSIGQLNLHVGLENGVYMKFHIGDVDGSFTDIKRRFLGLKPVSLSYLREISVSLNN 789

  Fly   712 -----------------RIKMQGSE---AVLAMSSRTWLSYYHQNRFHLTPLSYETLEYASGF-S 755
                             .|...|::   .|:..||.||:||..:|.:.:..|..:.:...|.| :
Yeast   790 EEEEEEEEDDDDEKEEEEINSSGAKWMSCVVCHSSSTWVSYTWKNVWTIRQLKDQNMLSCSKFVN 854

  Fly   756 SEQCSEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRTFVIHPDTGRMLIAETDHNAYTEDT 820
            ::....|:.:||::. |:    .:|.|.|   ||.  ....|.:|
Yeast   855 ADVAINGVCSISSSG-RL----NIGRVSN---FPT--LDNWFHVH-------------------- 889

  Fly   821 KSARKEQMAEEMRSAAGD-----EERELAREMANAFINEVLPEDVFSSPKAGLGLWASQIRCLDA 880
                 |....:..:..||     ||.|:..||....|:...|..:.|.|..     ...|..:|.
Yeast   890 -----ESSVNKQENGGGDESNEEEEDEMEEEMEMLQISTFRPRTILSFPNN-----PKSILFIDN 944

  Fly   881 MHGQTMFSVPL-TQNEAI-----------------MSMAMLKFSIAADGRYYLAVGIAKDLQLNP 927
            ..|:....:.| ...|.:                 :|.|::.|:..||   :|.: .|.|.:|.
Yeast   945 HSGKKQCRISLQIDGECLKFGSSDHLYKILDDIDCVSAAIIDFTRQAD---HLII-CAGDKRLL- 1004

  Fly   928 RISQGGCIDIYKI----DPTCSSLEFMHRTDIDEIPGALCGFQGRLLAGCGRMLRIYDFGKKKML 988
                     .|||    |.....:|.:|:|:|.....|:..|:..||...|..:.:|..|||::|
Yeast  1005 ---------TYKILVNKDKLSFDIELLHQTEIISPIHAMLKFKNFLLTAMGSTIVLYGLGKKQLL 1060

  Fly   989 RKCENKHIPYQIVNIQAMG----HRVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATTLL 1049
            |:...: .|..|..|.:|.    .|:.|.|:.|||....:..|.|..|.:.||:..|.||....|
Yeast  1061 RRSVTQ-TPVSITKIVSMHQWNYERLAVGDIHESVTLFIWDPAGNVFIPYVDDSVKRHVTVLKFL 1124

  Fly  1050 DYDTIAIADKFGNLSIQRLPHSVTDDV-DEDPTGTKSLWDRGLLSGA----------SQKSEN-- 1101
            |..|:..||::||....|.|......: :.||:        .|.:||          .||..|
Yeast  1125 DEATVIGADRYGNAWTLRSPPECEKIMSNHDPS--------ELSNGAIKYPLDVITLQQKLPNTY 1181

  Fly  1102 -----------------ICSFHVGEIIMSLQKATLIPGGSEALIYATLSGTVGAFVPFTSR---- 1145
                             |..||:.:.:.:..:    ||    .||..|.||||.|:|..|:
Yeast  1182 DCKFKFQLLNHFFVNDIITDFHILDSLSNSDR----PG----CIYMGLQGTVGCFIPLLSKGNVF 1238

  Fly  1146 -----------EDYDFFQHLEMHMRNENP------------------------------PLCGRD 1169
                       .|..|:...|...:|.|.                              .:.|||
Yeast  1239 MMGNIENIMAEADDTFYLDYESRKKNNNMRKEDDEEESGSVVLQGRHGIEDEIICEGSCSILGRD 1303

  Fly  1170 HLSYRSSYYPVKNVLDGDLCEQYLSIEAAKQKSIAGDMFRTP-NQICKKLEDIRTRY 1225
            |..|||.|.||:.|:||||||.:|.:...:|:.:|.::.... ..|.:.:.::||.|
Yeast  1304 HQEYRSYYAPVRKVIDGDLCENFLRLSLNEQEFLAKNLKSVQVEDIIQTINEVRTNY 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:463091	155/558 (28%)
		CPSF_A	872..1194	CDD:427182	105/422 (25%)
RSE1	NP_013663.1	MMS1_N	147..681	CDD:463091	155/560 (28%)
		CPSF_A	<1002..1328	CDD:427182	92/352 (26%)