Protein Alignment Sf3b3 and DDB1

DIOPT Version :10

• Sequence 1: NP_728546.1
• Gene: Sf3b3 / 38093
• FlyBaseID: FBgn0035162
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: NP_001914.3
• Gene: DDB1 / 1642
• HGNCID: 2717
• Length: 1140
• Species: Homo sapiens
• Alignment Length: 1280
• Identity: 285/1280 - (22%)
• Similarity: 517/1280 - (40%)
• Gaps: 206/1280 - (16%)

  Fly     2 YLYNLTLQKATGVTHAVHGNFSGGKQQEVLLSRGKSLEL-------LRPDSNTGKVHTLLSTEIF 59
            |.|.:|.||.|.|...|.|:|:..:...:|:::...||:       |||....|         ::
Human     3 YNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVG---------MY 58

  Fly    60 GCVRALMAFRLTGGTKDYIVVGSDSGRIVILEYNPSKNALE---KVH---QETFGKSGCRRIVPG 118
            |.:..:..||..|.:||.:.:.:......||||..|..:::   :.|   |:..|:.....|:.
Human    59 GKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIG- 122

  Fly   119 QYFAIDPKGRAVMIGAVEKQKLAYIMNRDTQARLTISSPLEAHKSNTLTYHMVGVDVGFDNPMFA 183
               .|||:.|.:.:...:.......::||       :..|:|........|:  :||.|   ::.
Human   123 ---IIDPECRMIGLRLYDGLFKVIPLDRD-------NKELKAFNIRLEELHV--IDVKF---LYG 172

  Fly   184 CLEIDYEEADMDPSGDAAQRTQQTLTFYELDLGLNHVVRKYSEPLEEHANFLVSVPGGNDGPSGV 248
            |..........||.|...:..:.:|...|.:.|     ....|.:|..|:.:::||   :...|.
Human   173 CQAPTICFVYQDPQGRHVKTYEVSLREKEFNKG-----PWKQENVEAEASMVIAVP---EPFGGA 229

  Fly   249 LICSENYLTYKNLGDQH-DIRCPIPRRRNDLDDPERGMIFIC-SATHRTKSMYFFLLQTEQGDIF 311
            :|..:..:||.| ||:: .|..||.::..          .:| :......|.|  ||...:|.:|
Human   230 IIIGQESITYHN-GDKYLAIAPPIIKQST----------IVCHNRVDPNGSRY--LLGDMEGRLF 281

  Fly   312 KITLETDDDV-----VSEIKLKYFDTVPPATAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDEP 371
            .:.||.::.:     :.:::::.......|..:..|..|.:||.|..|:..|.::.  .|.:::.
Human   282 MLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLN--VDSNEQG 344

  Fly   372 EFSSAMPLEEGETFFFAPRALKNLVLVDELPSFAPIITSQVADLANEDTPQLYVLCGRGPRSTLR 436
            .:..||     |||                .:..||:...|.||..:...||....|.....:||
Human   345 SYVVAM-----ETF----------------TNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLR 388

  Fly   437 VLRHGLEVSEMAVSELPGNPNAVWTVKKRADDEFDAYIIVSFVNATLVLSI-GETVEEVTDSGFL 500
            ::|:|:.:.|.|..:||| ...:|.::...:.|.|..:::|||..|.||.: ||.|||....||:
Human   389 IIRNGIGIHEHASIDLPG-IKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFV 452

  Fly   501 GTTPTLCCAALGDDALVQVYPDGIRHIRSDKR--VNEWKAPGKKSITKCAVNQRQVVITLSGREL 563
            ....|..|..:....|:|:....:|.:..:.:  |:|||.|..|:|:..:.|..|||:.: ||.|
Human   453 DDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAV-GRAL 516

  Fly   564 VYFEMDPTGELNEYTERSEMPAEIMCMALGTVPEGEQRSWFLAVGL-ADNTVRILSLDPNNCLTP 627
            .|.::.|. ||.:.: .:||..|:.|:.:..:.:....|...|:|| .|.:.|||.
Human   517 YYLQIHPQ-ELRQIS-HTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILK--------- 570

  Fly   628 CSMQALPSPAESLCLVEMGHTESTTQGGLDDDAPAQRS---GNNKGTIYLNIGLSNGVLLRTVLD 689
                 |||       .|:.|.|..  ||  :..|  ||   ...:.:.||...|.:|.|....|:
Human   571 -----LPS-------FELLHKEML--GG--EIIP--RSILMTTFESSHYLLCALGDGALFYFGLN 617

  Fly   690 PVSGDLADTRTRYLGSRPVKLFRIKMQGSEAVLAMSSRTWLSYYHQNRFHLTPLSYETLEYASGF 754
            ..:|.|:|.:...||::|..|...:...:..|.|.|.|..:.|...::...:.::.:.:.|....
Human   618 IETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPL 682

  Fly   755 SSEQCSEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRTFVIHPDTGRMLIAETDHNAYTED 819
            :|:...:.:...:.:||.|..::::..:..:.. ||..:||..                 .|.|.
Human   683 NSDGYPDSLALANNSTLTIGTIDEIQKLHIRTV-PLYESPRKI-----------------CYQEV 729

  Fly   820 TKSARKEQMAEEMRSAAGDEERELAREMANAFINEVLPEDVFSSPKA------GLGLWASQIRCL 878
            ::.........|::..:|............|..:.|....:|||..|      |..:....:..:
Human   730 SQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLII 794

  Fly   879 DAMHGQTMFSVPLTQNEAIMSMAMLKFSIAADGRYYLAVGIAKDLQLNPRISQGGCIDIYKIDPT 943
            |....:.:.:....|||..:|:...|  :..|...|..||.|..........||..:.....|
Human   795 DQHTFEVLHAHQFLQNEYALSLVSCK--LGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSD-- 855

  Fly   944 CSSLEFMHRTDIDEIPGALCGFQGRLLAGCGRMLRIYDFGKKKMLRKCENKHIPYQIVNIQAMGH 1008
             ..|:.:...::.....::..|.|:|||.....:|:|::..:|.||...|.:.....:.::..|.
Human   856 -GKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGD 919

  Fly  1009 RVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATTLLDYDTIAIADKFGNLSIQRLPHSVT 1073
            .:.|.|:..||..:.|:..|......|.|.:|.|::|..:||.|....|:...||.:.:...:.|
Human   920 FILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAAT 984

  Fly  1074 DDVDEDPTGTKSLWDRGLLSGASQKSENICSFHVGE----------IIMSLQKATLIPGGSEALI 1128
            .|.:.                  |..:.:..||:||          ::.:|.:.:....||  ::
Human   985 TDEER------------------QHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGS--VL 1029

  Fly  1129 YATLSGTVGAFVPFTSREDYDFFQHLEMHMR-NENPPLCGRDHLSYRSSYY------PVKNVLDG 1186
            :.|::|.:| .|...|...|:..  |:|..| |:.....|:...|:..|::      |....:||
Human  1030 FGTVNGMIG-LVTSLSESWYNLL--LDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDG 1091

  Fly  1187 DLCEQYLSIEAAKQKSIAGDM----------FRTPNQICKKLEDI 1221
            ||.|.:|.|...|.:.:..::          ..|.:.:.|.:|::
Human  1092 DLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEEL 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:463091	127/531 (24%)
		CPSF_A	872..1194	CDD:427182	73/338 (22%)
DDB1	NP_001914.3	Interaction with CDT1. /evidence=ECO:0000269|PubMed:15448697	2..768		201/882 (23%)
		WD repeat beta-propeller A	13..356		84/411 (20%)
		MMS1_N	75..543	CDD:463091	127/531 (24%)
		WD repeat beta-propeller B, Interaction with CUL4A	392..708		91/346 (26%)
		WD repeat beta-propeller C	709..1043		73/377 (19%)
		Interaction with CDT1 and CUL4A. /evidence=ECO:0000269|PubMed:15448697	771..1140		84/394 (21%)
		CPSF_A	789..1099	CDD:427182	73/337 (22%)