Protein Alignment Sf3b3 and pic

DIOPT Version :10

• Sequence 1: NP_728546.1
• Gene: Sf3b3 / 38093
• FlyBaseID: FBgn0035162
• Length: 1227
• Species: Drosophila melanogaster
• Sequence 2: XP_312466.2
• Gene: pic / 1273487
• VectorBaseID: AGAMI1_008550
• Length: 1138
• Species: Anopheles gambiae
• Alignment Length: 1300
• Identity: 283/1300 - (21%)
• Similarity: 513/1300 - (39%)
• Gaps: 252/1300 - (19%)

  Fly     4 YNLTLQKATGVTHAVHGNFSGGKQQEVLLSRGKSLEL-------LRPDSNTGKVHTLLSTEIFGC 61
            |.:|.||.|.||..|.|||:......:::::...||:       |||....|         |.|.
Mosquito     5 YIVTAQKPTAVTACVTGNFTSPTDLNLIVAKSSRLEIYLVTPEGLRPIKEIG---------INGK 60

  Fly    62 VRALMAFRLTGGTKDYIVVGSDSGRIVILEYNPSKNALE---KVHQETFGKSGCRRIVPGQYFAI 123
            :..:..||....|||.|.:.:.....:||:.....:.:|   |.|.....:.| :....|....|
Mosquito    61 IAVMKLFRPAEETKDLIFILTHRYNAMILQCAVQGDDIEIITKAHGNVADRVG-KPAETGILAVI 124

  Fly   124 DPKGRAVMIGAVEKQKLAYIMNRDTQARLTISSPLEAHKSNTLTYHMVGVDVGFDNPMFACLEID 188
            |||.|.:.:...|.......:::||       :.|:|........|:..|:..:..
Mosquito   125 DPKARVIGMRLYEGLFKIIPLDKDT-------NELKATSLRMEEMHVQDVEFLYGT--------- 173

  Fly   189 YEEADMDPSGDAAQRTQQTLTFYELDLGLNHV--------------VRKYSEPLEEHANFLVSVP 239
                           |..||.....|:...|:              :....:.:|..|..|::||
Mosquito   174 ---------------THPTLIVIHQDINGRHIKTHEISLKDKEFTKIAWKQDNVETEATMLIAVP 223

  Fly   240 GGNDGP-SGVLICSENYLTYKNLGDQHDIRCPIPRRRNDLDDPERGMIFICSATHRTKSMYFFLL 303
                .| .|.::..:..:.|.: ||.:....|...:::.::         |.|...:|.:. :||
Mosquito   224 ----MPLGGAIVIGQESIVYHD-GDSYVAVAPAIIKQSTIN---------CYARIDSKGLR-YLL 273

  Fly   304 QTEQGDIFKITLETDDD-----VVSEIKLKYFDTVPPATAMCVLKTGFLFVASEFGNHYLYQIAH 363
            ....|::|.:.|||:::     .|.:||::....:.....:..|..|.||:.|..|:..|.::..
Mosquito   274 GNMAGNLFMMFLETEENAKGQTTVRDIKVELLGEITIPECITYLDNGVLFIGSRHGDSQLVKLNT 338

  Fly   364 LGDDDDEPEFSSAMPLEEGETFFFAPRALKNLVLVDELPSFAPIITSQVADLANEDTPQLYVLCG 428
            ...|:.                       ..::|::...:.|||:...|.||..:...|:....|
Mosquito   339 TAGDNG-----------------------AYVMLMETFTNLAPIVDMCVVDLERQGQGQMITCSG 380

  Fly   429 RGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWTVKKRADDE-FDAYIIVSFVNATLVLSI-GETV 491
            .....:||::|:|:.:.|.|..:||| ...:|.::...||. :|..:|:|||..|.||.: |:.|
Mosquito   381 SFKEGSLRIIRNGIGIQEHACIDLPG-IKGMWALRVGIDDSPYDNTLILSFVGHTRVLMLSGDEV 444

  Fly   492 EEVTDSGFLGTTPTLCCAALGDDALVQVYPDGIRHIRSDKR--VNEWKAPGKKSITKCAVNQRQV 554
            ||...:|.||...|..||.:....::||.|...|.|..|.:  :.|||.|..|.|.....|..|:
Mosquito   445 EETEIAGILGDQQTFYCANVSHGQILQVTPSSARLISCDNKAMICEWKPPDNKRIGVVGANTTQI 509

  Fly   555 VITLSGRELVYFEMDPTGELNEYTERSEMPAEIMCMALGTVPEGEQRSWFLAVGLADNTVRILSL 619
            |.. |.:::.|.|:. .|:| ||..::.:..|:.|:.:..:.:...||.|:||||
Mosquito   510 VCA-SAQDVYYVEIG-DGKL-EYKGQTTLSYEVACLDVSPLEDNATRSEFVAVGL---------- 561

  Fly   620 DPNNCLTPCSMQALPSPAESLCLVEMGHTESTTQGGLDDDAPAQRS---GNNKGTIYLNIGLSNG 681
                 .|..|...|..|.     :|:.|.|..  ||  :..|  ||   ...:|..||...|.:|
Mosquito   562 -----WTDISACVLKVPT-----LELLHKEKL--GG--EIIP--RSILMAAFEGINYLLCALGDG 610

  Fly   682 VLLRTVLDPVSGDLADTRTRYLGSRPVKLFRIKMQGSEAVLAMSSRTWLSYYHQNRFHLTPLSYE 746
            .:...||:..:|.|.:.:...||::|..|...:...:..|.|.|.|..:.|...::...:.::.:
Mosquito   611 SMYYFVLNKATGCLTEQKKVTLGTQPTILKTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLK 675

  Fly   747 TLEYASGFSSEQCSEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRTFVIHPDTGRMLIAET 811
            .:.:....::|...:.:...:.|::....::::..:..:.. ||..:||..
Mosquito   676 EVNHMCSLNAEAYQDSLALATRNSVIFGTIDEIQKLHIRTV-PLGESPRRI-------------- 725

  Fly   812 DHNAYTEDTKSARKEQMAEEMRSAAGDEERELAREMANAFINEVLPEDVFSSPKAGLGLW----- 871
               ||.|.:::........:::.::|   ...||:.|:...|.:       :..:|:||.
Mosquito   726 ---AYQEASQTFGVITFRMDVQDSSG---LTPARQSASTQTNNI-------TQSSGMGLLKPGAS 777

  Fly   872 ---------ASQIRCLDAMHGQTMFSVPLTQNEAIMSMAMLKFSIAADGRYYLAVGIAKDLQLNP 927
                     ...:..:|....:.:.:....|.|..:|:...|.....:..:.:..|:....:..|
Mosquito   778 NTEFGQEVEVHNLLIIDQNTFEVLHAHQFMQTEYALSLMSAKLGNDPNTYFIVGTGLVNPEEPEP 842

  Fly   928 RISQGGCIDIYKIDPTCSSLEFMHRTDIDEIPGA---LCGFQGRLLAGCGRMLRIYDFGKKKMLR 989
            :.   |.|.||:.    :..|....:| .|:.||   |..|.||:||.....:|:|::...|.||
Mosquito   843 KT---GRIIIYRY----ADNELKMVSD-KEVKGACYSLVEFNGRVLACINSTVRLYEWTDDKDLR 899

  Fly   990 -KCENKHIPYQIVNIQAM-----GHRVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATTL 1048
             :|.:.:      |:.|:     |..:.|.|:..|:..::|::.|......|.|..|.|:||..:
Mosquito   900 LECSHFN------NVLALYCKTKGDFILVGDLMRSITLLQYKQMEGSFEEIARDYQPNWMTAVEI 958

  Fly  1049 LDYDTIAIADKFGNLSIQRLPHSVTDDVDEDPTGTKSLWDRGLLSGASQKSENICSFHVGEIIMS 1113
            ||.|....||...||.:.....:.|.|.:.                  |:...:..||:|:::..
Mosquito   959 LDDDAFLGADNSNNLFVCLKDSAATTDEER------------------QQMPEVAQFHLGDMVNV 1005

  Fly  1114 LQKATLIPGG-SE-------ALIYATLSGTVGAFVPFTSREDYDFFQHLEMHMRNENPPLCGRDH 1170
            .:..:|:... ||       .:::.|:||.:|......| :.|:|.:.|:.::.|....:...||
Mosquito  1006 FRHGSLVMQNISERSTPTTGCVLFGTVSGAIGLVTQIQS-DFYEFLRKLQENLTNTIKSVGKIDH 1069

  Fly  1171 LSYRSSYYPVK-----NVLDGDLCEQYLSIEAAKQK--------SIAGDMFR-TPNQICKKLEDI 1221
            ..:||.:...|     ..:||||.|.:|.:...|.:        .:.|.... |.:.|.|.:||:
Mosquito  1070 SYWRSFHTETKMERCEGFIDGDLVESFLDLSREKMREASLGLEIDVEGTKREATVDDIIKIVEDL 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:463091	121/542 (22%)
		CPSF_A	872..1194	CDD:427182	77/343 (22%)
pic	XP_312466.2	MMS1_N	75..544	CDD:463091	121/542 (22%)
		CPSF_A	788..1098	CDD:427182	77/342 (23%)