DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vti1a and VTI1

DIOPT Version :9

Sequence 1:	NP_612053.1	Gene:	Vti1a / 38085	FlyBaseID:	FBgn0260862	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_013924.1	Gene:	VTI1 / 855237	SGDID:	S000004810	Length:	217	Species:	Saccharomyces cerevisiae

Alignment Length:	232	Identity:	66/232 - (28%)
Similarity:	118/232 - (50%)	Gaps:	31/232 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLEQYEQQYATLIAEITAHIGRLQQQNNNSERHDLCSKIDSSLPEAQELLEQMGLEVREL--NP 64
            |||..||..:.|.:.:..|.:.....| ..|:|:.....::....|..:||:||.:||...  :.
Yeast     3 SLLISYESDFKTTLEQAKASLAEAPSQ-PLSQRNTTLKHVEQQQDELFDLLDQMDVEVNNSIGDA 66

  Fly    65 GLRSSFNGKL----QVAQAELKR-LQAEYRLTKDKQRSQANTFTTLDLGDS---YEDV---SIST 118
            ..|:::..||    :..|:::|| ||                 :.:|.||.   :.|:   :|..
Yeast    67 SERATYKAKLREWKKTIQSDIKRPLQ-----------------SLVDSGDRDRLFGDLNASNIDD 114

  Fly   119 DQRQRLLDNSERIERTGNRLTEGYRVALETEQLGAQVLNDLHHQRETLQGARARLRETNAELGRA 183
            ||||:||.|...::::|:||.:..|:|.|||.:|:|::.||..|||||:.||..|.:.::.:.::
Yeast   115 DQRQQLLSNHAILQKSGDRLKDASRIANETEGIGSQIMMDLRSQRETLENARQTLFQADSYVDKS 179

  Fly   184 SRTLNTMMLRALREKVVLYGVGVCFVVAVGVSLYLTF 220
            .:||.||..|.:..|.:.|.:....::.:.:.|:..|
Yeast   180 IKTLKTMTRRLVANKFISYAIIAVLILLILLVLFSKF 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vti1a	NP_612053.1	V-SNARE	11..89	CDD:282816	20/84 (24%)
Vti1a	NP_612053.1	SNARE_Vti1a	128..189	CDD:277244	22/60 (37%)
VTI1	NP_013924.1	V-SNARE	12..92	CDD:398604	18/80 (23%)
VTI1	NP_013924.1	SNARE_Vti1	127..185	CDD:277215	22/57 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342087
Domainoid	1	1.000	55	1.000	Domainoid score	I2738
eggNOG	1	0.900	-	-		E1_KOG1666
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I1542
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54893
OrthoFinder	1	1.000	-	-		FOG0003233
OrthoInspector	1	1.000	-	-		oto99040
orthoMCL	1	0.900	-	-		OOG6_101479
Panther	1	1.100	-	-	O	PTHR21230
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1665
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790