Protein Alignment Rev1 and Polh

DIOPT Version :10

• Sequence 1: NP_612047.1
• Gene: Rev1 / 38079
• FlyBaseID: FBgn0035150
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_109640.1
• Gene: Polh / 80905
• MGIID: 1891457
• Length: 694
• Species: Mus musculus
• Alignment Length: 731
• Identity: 144/731 - (19%)
• Similarity: 243/731 - (33%)
• Gaps: 224/731 - (30%)

  Fly   273 RYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHS---KGGNAATDVPVHPQADRKAELELFAQRFE 334
            |.|..:|||||||.|..|..|.||..|.||...   |||.
Mouse     7 RVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGG------------------------- 46

  Fly   335 HHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIPY------- 392
                                    |.:.|||||..|:...|:...|.||||:|.....
Mouse    47 ------------------------IIAVSYEARAFGVTRNMWADDAKKLCPDLLLAQVRESRGKA 87

  Fly   393 DFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHE---------LNVDVM--------- 439
            :...|:|.:..:.:.::.:.: ||..|.||.:::||....|         ::.|::
Mouse    88 NLTKYREASVEVMEIMSYFAV-IERASIDEAYIDLTSAVQERLQKLQGQPISADLLPSTYIEGLP 151

  Fly   440 ------------------------------------------AFVSHLRQEVYSKTGCPCSAGVA 462
                                                      ..|..:|..:.||||..||||::
Mouse   152 RGPTVEETVQKEAIRKQGLLQWLDSLQSDDPTSPDLRLTVGAMIVEEMRAAIESKTGFQCSAGIS 216

  Fly   463 GNKLLARMATKEAKPNGQFLLD--SSNDILAYMAPMSLDLLPG-VGSSISHKLKQAGLNNCGDVQ 524
            .||:||::|....|||.|.|:.  |...:.:.|....:..|.| :|:|:   ::..|:...||:.
Mouse   217 HNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASV---IEVLGIEYMGDLT 278

  Fly   525 NTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNF--GIRFTNSVECEQFLCQL 587
            ..|..:::...|:|.|..|:..||||:..|:...|:.||:....||  ........:.:.:|.||
Mouse   279 QFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQL 343

  Fly   588 SEEVTKRLVEIRRKARSINLKIMV--------------RAAEAPVETSKYMGHGVCDIINKSSLI 638
            :.|:.:||.:.|.....:..:::|              |....|...:..|.......|...:..
Mouse   344 ALELEERLTKDRNDNDRVATQLVVSIRFQGDRRLSSLRRCCALPRYDAHKMSQDAFAAIRNCNTS 408

  Fly   639 KYATDDVNVITTVVLDLMK-DADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSEMRKDK 702
            ...|:....:|.:.|...| .|..||                    ...:|.......|..:...
Mouse   409 GIQTEWSPPLTMLFLCATKFSAAAPP--------------------ACTDITAFLSSDSSCQPKV 453

  Fly   703 PIPQGAVGDKSIGDDKVNKPLVFENKPKPREPRNVLSMLTAAAVSRKSVTEDRSQRGTSKPI--- 764
            ||.......:..|               |..|.:..:..:.|:..:|:..:.|.:..:..|:
Mouse   454 PIASSETRTQGSG---------------PAVPTSKEAATSLASFFQKAAKKQRMKETSFVPLNTA 503

  Fly   765 TRPLSLVPKLDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRS-----PPLLNPYV 824
            |..||..|.|    :.|..:....:....::..|.          |:..|.:     ||..:|..
Mouse   504 TEKLSSKPSL----VFQSSQTTGSQSFFKQKSLLL----------QHTQLSNSAAPDPPQASPAA 554

  Fly   825 TTNVSPLKATD-------LKPSTSRAAVARLQKRKE-----------RKEQEHYIRSDQIVADYI 871
            ..:..|.:..|       :||.:|:|....:....:           .:|.......||::.:..
Mouse   555 QPSCLPAECVDSGPDDGAVKPVSSKAVSTEMNVAGDSPNVLDSPAYNSQEVTQRATEDQVLCEKC 619

  Fly   872 D------DLPDFVNPH 881
            |      |:|:..:.|
Mouse   620 DSLVPVWDMPEHTDYH 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	108/492 (22%)
		Rev1_C	890..985	CDD:213388
Polh	NP_109640.1	PolY_Pol_eta	10..427	CDD:176456	102/469 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..598		5/32 (16%)
		zf_UBZ	612..642	CDD:465769	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..694
		PIP-box. /evidence=ECO:0000250|UniProtKB:Q9Y253	682..689