Protein Alignment Rev1 and rev1

DIOPT Version :10

• Sequence 1: NP_612047.1
• Gene: Rev1 / 38079
• FlyBaseID: FBgn0035150
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: XP_073768289.1
• Gene: rev1 / 570043
• ZFINID: ZDB-GENE-081105-180
• Length: 1284
• Species: Danio rerio
• Alignment Length: 1279
• Identity: 373/1279 - (29%)
• Similarity: 569/1279 - (44%)
• Gaps: 338/1279 - (26%)

  Fly     1 MTRD-------EDNGFSEWGGYFEAKKSKLEEQFAAASDPFRKSD-----LFQGISIFVNGRTDP 53
            |:||       |::|:...|||..||.|||||||...:...:|.|     :|.|::|:|||.|||
Zfish    23 MSRDGWRKKASENDGWGGQGGYMAAKVSKLEEQFQKDAPREQKKDGKSSCIFSGVAIYVNGYTDP 87

  Fly    54 SADELKRIMMVHGGTFH-HYERSHTTYIIASVLPDVKVRNMNLSKFISAKWVVDCLEKKKIVDYK 117
            ||.||:|:||:|||.|| :|.||.||:|||:.||:.|::.:...|.:..:|::|.::..:.:.|.
Zfish    88 SAAELRRLMMLHGGQFHLYYSRSKTTHIIATNLPNFKIQELKGEKVVRPEWIIDSIKAGRQLSYI 152

  Fly   118 PYLLYTNQKTSQPMLIFG--------------KP-------KD---------------------- 139
            .|.||..||......:.|              ||       ||
Zfish   153 QYQLYAKQKGLNFTRVSGIEGQDPSSNHGPDIKPQPSHTLSKDVLKSTQANHMANYTEKTDHQLD 217

  Fly   140 ----NGANESKSDVEPPKDKAE-VEVDSTKDETQMEL------------------GGILK----- 176
                ||.:...|:|:..|.:.. :..|...|:....:                  .|.||
Zfish   218 IRLRNGLHSIISEVDAEKSRVNGIHDDDDDDDIACSILPRGSQDTLLTNGHVHPVNGALKPQDFA 282

  Fly   177 --------------------------------------NLQQAV-ATSPEKE------------- 189
                                                  :|:..: |.||.|:
Zfish   283 DHHPHVVDKASNQSHLPQDKYREGEEPCCSYTESKANSHLRSLISAASPAKQPGPHNMQTDLHQK 347

  Fly   190 -------------ASASESKITNLS----TTSNNSTTA-------RTAADPNFLSEFYKNSRLHH 230
                         ||..:.....|:    .|||:||.|       :::|:...:|||:.:|||||
Zfish   348 PTSNSGTLGAPQKASLHDQTTVRLNGSYHVTSNSSTLANSSNQSGKSSAEAGIISEFFSHSRLHH 412

  Fly   231 IATLGAGFKQYVCRLRQKHGTQG---FPKRETLKSL-ANSHHNCL-------ERYVMHIDMDCFF 284
            |:|....|.:||..|:.:....|   |..||.||.| ||.:...|       :..|:|:||||||
Zfish   413 ISTWRNEFSEYVNSLQSRRRAAGGAVFSGREKLKKLKANCNSGSLMAAPQVRQSCVLHVDMDCFF 477

  Fly   285 VSVGLRTRPELRGLPIAVTHSKG-GNAATDVPVHPQADRKAELELFAQRFEHHFH---DGD---- 341
            ||||:|.||:|.|.|:|||.::| |..|.    .|.|:.:.|.:.:..:.:|:..   |||
Zfish   478 VSVGIRHRPDLIGKPVAVTSNRGPGRVAQ----RPGANPQLEFQYYQNKQKHYRKEKTDGDLEMT 538

  Fly   342 ----KAEKVRSGFDK---KMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIPYDFEGYKE 399
                ..|...:|..:   .:|::||||||||||:.|:|||||.|:|.:|||:|:::||||..|||
Zfish   539 PSPQDGEVPSNGVHEDLAALSMAEIASCSYEARQAGVRNGMFFGRAKQLCPDLQSVPYDFHAYKE 603

  Fly   400 VAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHELNVDVMAFVSHLRQEVYSKTGCPCSAGVAGN 464
            ||..:|:.:|.||.||||:||||..|:.|.|..||.|........:|:::..||||..|.|::.|
Zfish   604 VALAMYEILASYTHNIEALSCDEALVDATALLVELGVSPDELARSIREDIKEKTGCCASVGMSSN 668

  Fly   465 KLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGDVQNTTLE 529
            .|||||||::|||.||:|| .|.::..::....:..|||||.|:|.||...|::.|||:|..:|.
Zfish   669 ILLARMATRKAKPKGQYLL-RSEEVDDFIRDQPVSSLPGVGRSMSSKLTSLGVSTCGDLQQLSLS 732

  Fly   530 KMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVECEQFLCQLSEEVTKR 594
            ::::..|.:.||.||:.|||:||||:..|:.||:||||||:.||||...|.|.||..||.||.||
Zfish   733 QLQREFGPRTGQTLFRFCRGLDDRPVRSEKERKSVSAEMNYNIRFTQVEEAESFLNNLSMEVQKR 797

  Fly   595 LVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIINKSSLIKYATDDVNVITTVVLDLMKDA 659
            |.....:.|.:.||:|:|...||||.:||.|||:||...:|.|:...||...||.:..:.|....
Zfish   798 LEGAGLRGRRVTLKVMMRKPGAPVEPAKYGGHGICDNFARSVLLAQPTDSGRVIASEAIKLFHAM 862

  Fly   660 DIPPDELRGLGIHLTRLEDANE------VRKENNIKE-MFGKMS--EMRKDKPIPQGAVGDK--- 712
            .:...::||:|:.:.:|:.::.      ..:..:|:: :..|.|  ...|:.|...|.:...
Zfish   863 KLNVKDMRGVGLQVQQLDGSHADPSGQGPSRGRSIRDLLLAKQSAHSPSKESPSQDGLISASSSR 927

  Fly   713 --SIGDDKVNKPL-----------------VFENKP--------KPREPRNVL------------ 738
              |....:|...|                 :.:..|        .|..|.:|.
Zfish   928 AFSSNQKRVTPALSPPPSTSSSSSPPPSFTIIDPMPGTSKGDYHHPHTPNHVRACLNISIEVPSP 992

  Fly   739 -----SMLTAAAVSRKSVTEDRSQRGTSKPIT--------RPLSLVP------------------ 772
                 |:|.|..:..:...|:..:....:|.|        ||.|..|
Zfish   993 SQVDPSVLKALPIDIRRQVEETWRYREEQPSTSSHYSTPPRPPSTPPPGPSLVLQLPNQPGQPCT 1057

  Fly   773 -----------KLDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSP---------------QY 811
                       ::|.||.|.||.::        :|.||.|    ||:.               .:
Zfish  1058 TGIILELPDFSQVDPDVFAALPREL--------QEELCSA----YRNKGNAQAQASTVVEQKNSF 1110

  Fly   812 PTLRSP---PLLNPYVTTNVSPLK--ATDLK---PSTSRAAVARLQKRKERKEQEHYIRSDQIVA 868
            |.|:.|   .|...|...|.||.|  ::.||   |..|.|      |....|.....:|...:
Zfish  1111 PQLKQPAVGKLKRRYKKRNTSPAKNGSSPLKKMFPGNSPA------KTSPSKTLPLPLREQDL-- 1167

  Fly   869 DYIDDLPDFVNPHILKLISHPVEMP-ELLMG----DNYKDLLNDWVSREEVPKPNDVDLILKQVS 928
                ..|..::..:.:.:..|:..| ..|.|    ...:.||.:||:....|...|:..::|..:
Zfish  1168 ----KCPSSLSTDVPETLPKPIPRPAPTLAGAHEFSEIRTLLREWVTTISEPMEEDILQVVKYCT 1228

  Fly   929 RMIKNDQLDHVCDVMKYWCRIINMKRSSSCCWHVAYKHIEESIQ 972
            .::::..|:.:..|:||..|:  |::||...|.:|:..:.:::|
Zfish  1229 ELVEDKDLEKLYLVIKYMKRL--MQQSSESVWSMAFDFVLDNVQ 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351	37/82 (45%)
		PolY_Rev1	218..676	CDD:176455	207/483 (43%)
		Rev1_C	890..985	CDD:213388	21/88 (24%)
rev1	XP_073768289.1	None