Protein Alignment Rev1 and Rev1

DIOPT Version :10

• Sequence 1: NP_612047.1
• Gene: Rev1 / 38079
• FlyBaseID: FBgn0035150
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_001381058.2
• Gene: Rev1 / 316344
• RGDID: 1306715
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 1269
• Identity: 370/1269 - (29%)
• Similarity: 555/1269 - (43%)
• Gaps: 356/1269 - (28%)

  Fly     3 RDEDNGFSEWGGYFEAKKSKLEEQFAAASDPFRKSD-----LFQGISIFVNGRTDPSADELKRIM 62
            |.|::|:.:||||..||..||||||  .||..::.|     :|.|::|:|||.|||||:||:.:|
  Rat     9 RAEEDGWEKWGGYMAAKVQKLEEQF--RSDAAKQKDGTASAIFSGVAIYVNGYTDPSAEELRNLM 71

  Fly    63 MVHGGTFH-HYERSHTTYIIASVLPDVKVRNMNLSKFISAKWVVDCLEKKKIVDYKPYLLYTNQK 126
            |:|||.:| :|.||.||:|||:.||:.|::.:...|.|..:|:|:.::..:::...||.|||...
  Rat    72 MLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSSVPYQLYTKPS 136

  Fly   127 TSQPMLIFG---KP-------------------------------KDNGA---NESKSD------ 148
            |:|..|.|.   ||                               |.||.   ||..:|
  Rat   137 TAQKSLNFTPVCKPEEPVPGPSEIAKQLTNRVNHIIKKIETENEVKANGVSSWNEDSADDGFSSE 201

  Fly   149 -------------VEPPKDKA-----------------------------EVEVDSTKDETQMEL 171
                         |..|:|.|                             .:.:|||::|.:.|.
  Rat   202 GLGQTFPGRKQNGVMHPRDTAVIFNGHAHSSNGALKTQDCLVPVDHSVASRLSLDSTQEEKRAEK 266

  Fly   172 GGI------LKNLQQAVAT-----SPEKEASASESKITNL-------STTSNNSTTARTAA---- 214
            ...      .::||.:...     ||.:.:|.|.|..:|.       ||....|:|..|:|
  Rat   267 SSTDFRDCSRQHLQHSTTNADTLCSPHRTSSLSPSLHSNTKINGAHHSTVQGPSSTKSTSALTLS 331

  Fly   215 -----------DPNFLSEFYKNSRLHHIATLGAGFKQYVCRL-RQKHGTQGFPKRETLKSLANSH 267
                       |.:|:|:||..||||||:|......::|..| ||:.|.  ||.||.||.:....
  Rat   332 KVAPSVPSKPSDCSFISDFYSRSRLHHISTWKCELTEFVSALQRQRSGV--FPGREKLKKVKTGR 394

  Fly   268 HNCL---------------ERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVH 317
            .:.:               :..|||:||||||||||:|.||:|:|.|:|||.::|...|   |:.
  Rat   395 SSLVVTDTGDMSVLSSPRPQSCVMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRA---PLR 456

  Fly   318 PQADRKAELELFAQRF----------EHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIR 372
            |.|:.:.|.:.:..:.          ...:.:.|.|:  .:|.|..:|.:||||||||||:.||:
  Rat   457 PGANPQLEWQYYQNKLLKGKAADIPDSSVWENQDSAQ--TNGIDSVLSKAEIASCSYEARQVGIK 519

  Fly   373 NGMFVGQALKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHELNVD 437
            ||||.|.|.:|||.|:.:||||...:|||..||:|:|.||.:||||||||..:::||:..|..:.
  Rat   520 NGMFFGHAKQLCPNLQAVPYDFHACREVAQALYETLASYTHSIEAVSCDEALIDVTDILAETKLS 584

  Fly   438 VMAFVSHLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQFLL--DSSNDILAYMAPMSLDL 500
            ...|.:.||.|:.:||.|..|.|:..|.||||||||:|||:||:.|  |..:|.:......|
  Rat   585 PEEFAAALRMEIKNKTQCAASVGIGSNILLARMATKKAKPDGQYHLQPDEVDDFIRGQLVTS--- 646

  Fly   501 LPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVS 565
            |||||.|:..||...|:..|||:|..|:.|::|..|.|.||.|::.|||:||||:..|:.||:||
  Rat   647 LPGVGRSMESKLASLGIKTCGDLQCLTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVS 711

  Fly   566 AEMNFGIRFTNSVECEQFLCQLSEEVTKRLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCD 630
            ||:|:|||||...|.|.||..||.|:..||.....|.:.:.||||||...||:||:|:.|||:||
  Rat   712 AEINYGIRFTQPREAEAFLLSLSGEIQSRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICD 776

  Fly   631 IINKSSLIKYATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDAN--------------- 680
            .|.::..:..|||...:|....|::.....:...::||:||.:.:|..||
  Rat   777 NIARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVHQLVPANLHPSTCSSRPSAQSS 841

  Fly   681 -----------------------------------EV---------------------------- 682
                                               ||
  Rat   842 LFSGLPHSVRDLFQLQKAKKPTEEEHNEGLAAVDLEVSSNSRACGLLSPPSAHLATVSPDANRGE 906

  Fly   683 --RKENNIKEMFGKMSEMRKDKPIPQGAVGDKSI--------------------GDDKVNK---- 721
              ||.|.:....|..|.:.....:|..:..|:|:                    |:.:.:|
  Rat   907 CSRKWNGLHSPIGGQSRLNLSIEVPSPSQIDQSVLEALPPDIREQVEQAYAAQQGEPRGSKKKEP 971

  Fly   722 -----------PL--VFENKPKPREPRNVLSMLTAAAVSRKSVTEDRSQRGTSKPITRPLSLVPK 773
                       |:  |....|:|:||.|..:.::..|                      |....:
  Rat   972 VNGCSSGVLPHPVGTVLLQIPEPQEPNNSDTRISVIA----------------------LPAFSQ 1014

  Fly   774 LDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRSPPLLNPYVTTNVSPLKATDLKP 838
            :|.||.|.||.:::.|:.|..::.....|....:.|...::...|||              .|||
  Rat  1015 VDPDVFAALPAELQKELKAAYDQRQRQGEDTTQQQPASTSVPKNPLL--------------QLKP 1065

  Fly   839 STSRAAVARLQKRKERKEQEHYIRSDQIVADYIDDLPDFVNPHILKLISHPVE------------ 891
            .      |...||.:||......|..|.:.. ....|..:....|:....|:|
  Rat  1066 P------AMKDKRNKRKNPIGSPRKIQSLPG-TSGSPQKLMDGFLQHEERPLEEVSASTPGAQSL 1123

  Fly   892 ---------------MPELLMGDNYKD---LLNDWVSREEVPKPNDVDLILKQVSRMIKNDQLDH 938
                           .|.|.....:.|   ||.:|::....|...|:..::|..:.:|:...|:.
  Rat  1124 SGLQCGSQSSCFRPAAPNLAGAVEFSDVKTLLKEWITTISDPMEEDILQVVKYCTDLIEEKDLEK 1188

  Fly   939 VCDVMKYWCRIINMKRSSSCCWHVAYKHIEESIQ 972
            :..|:||..|:  |::|....|::|:..|.:::|
  Rat  1189 LDLVIKYMKRL--MQQSVESVWNMAFDFILDNVQ 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351	36/82 (44%)
		PolY_Rev1	218..676	CDD:176455	205/485 (42%)
		Rev1_C	890..985	CDD:213388	22/113 (19%)
Rev1	NP_001381058.2	BRCT_Rev1	48..131	CDD:349351	38/83 (46%)
		PolY_Rev1	346..822	CDD:176455	189/594 (32%)
		Rev1_UBM2	927..960	CDD:412037	8/32 (25%)
		Rev1_UBM2	1004..1039	CDD:412037
		Rev1_C	1140..1233	CDD:213388