Protein Alignment Rev1 and rev-1

DIOPT Version :10

• Sequence 1: NP_612047.1
• Gene: Rev1 / 38079
• FlyBaseID: FBgn0035150
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: NP_495663.1
• Gene: rev-1 / 174275
• WormBaseID: WBGene00014066
• Length: 1027
• Species: Caenorhabditis elegans
• Alignment Length: 866
• Identity: 253/866 - (29%)
• Similarity: 409/866 - (47%)
• Gaps: 181/866 - (20%)

  Fly     5 EDNGFSEWGGYFEAKKSKLEEQF-AAASDPFRK-SDLFQGISIFVNGRTDPSADELKRIMMVHGG 67
            |.|.|::   |...|.:||..|. ...:.|... |.:.:|.|:||||.|||.|..::.:|:.|||
 Worm   222 EINNFND---YMRMKITKLNHQVNHGYAKPLENVSRIMEGFSVFVNGYTDPPALVIRDLMISHGG 283

  Fly    68 TFH-HYERSHTTYIIASVLPDVKVRNMNLSK-FISAKWVVDCLEKKKIVDYKPYLLYTNQKTSQP 130
            .:| :|:...|:|.|||.:...|:..:..:: ||.|.|:.:.:...|.:||:.:|:|
 Worm   284 EYHCYYQHGITSYTIASSIATAKINRIRENEIFIKADWITESIAAGKPLDYRDFLIY-------- 340

  Fly   131 MLIFGKPKDNGANESKSDVEPPKDKAEVEVDSTKDETQMELGGILKNLQQAVATSPEKEASASES 195
                                                   |.|.:.|...|...|
 Worm   341 ---------------------------------------EKGSVEKGQMQQFLT----------- 355

  Fly   196 KITNLSTTSNNSTTART----AADPNFLSEFYKNSRLHHIATLGAGFKQYVC--RLRQKHGTQGF 254
             |:..:|..||.||:..    |.:|||:.::|..||||.|:||....|.:|.  :|..|...:.|
 Worm   356 -ISTRNTGGNNETTSSNQFSDARNPNFIRDYYARSRLHLISTLAQDMKDFVANLKLEGKLTEKCF 419

  Fly   255 PKRE--TLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKG--GNAATDVP 315
            .::|  .:|||:|....  |..|.|:|:|||||||.:|.|.:|:...:|:|||||  .|
 Worm   420 EEKELIDMKSLSNEISR--ESTVFHVDLDCFFVSVAVRNRIDLKHKEVAITHSKGTISN------ 476

  Fly   316 VHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQA 380
                                                   |:||:|||||.||:.|::|||.|..|
 Worm   477 ---------------------------------------SMSEVASCSYAARDCGVKNGMLVRDA 502

  Fly   381 LKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLA--HELNVDVMAFVS 443
            |:.||:|..:||.||.|.:|:..:|:.:|.|||.:.|||||||::.::...  :|:| |......
 Worm   503 LQKCPQLTLLPYQFEDYVQVSRKIYEILASYTLEVRAVSCDEMYINMSSFCEKYEIN-DPTILAE 566

  Fly   444 HLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQFLLDS--SNDILAYMAPMSLDLLPGVGS 506
            |:|:.:..||.||.|.|:....||||:||:.|||:|.|.:::  .|:   :::...:..|||.|.
 Worm   567 HIRKVIREKTQCPASVGIGSTSLLARLATRHAKPDGVFWVNAHKKNE---FISEEKVKDLPGFGY 628

  Fly   507 SISHKLKQ--AGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAY--EQIRKTVSAE 567
            .:.::|..  ..:..|.::|..|..::..|.|.||...:.:.||||::.|..:  ..:||:||.:
 Worm   629 EMMNRLTSFFGDITKCRELQLKTERELVPVFGPKLASKILRQCRGIEEDPDDFWATHVRKSVSCD 693

  Fly   568 MNFGIRFTNSVECEQFLCQLSEEVTKRLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDII 632
            :|:|||||...|..|.:..:..|:.::|::.:..|.||.||:|||:|.||::|||:||||:||..
 Worm   694 INYGIRFTKRGEVIQLMTAIGAELERKLIDSKLTAGSITLKLMVRSANAPIQTSKFMGHGICDTF 758

  Fly   633 NKSSLIKYATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSE 697
            .|:..:...|.....:|:..:.|........::|||:|:...:|:...:......::|||||.|.
 Worm   759 TKTCNLNVPTTRGESLTSEAMKLYAKVSPKVEDLRGVGVTCGKLKSKLKKDAATAVQEMFGKTSR 823

  Fly   698 MRKDKPIPQGAVGDKSIGDDKVNKPLVFENKPK-PREPRNVLSMLTAAAVSRKSVTEDRSQRGTS 761
                       ||:.:..|:::|  ::..|:.: .:||           |...:||||...:...
 Worm   824 -----------VGNMARTDEQLN--IIPRNEDELDKEP-----------VIIPAVTEDLEVQSIP 864

  Fly   762 KPITRPLSL---VPKLDEDVLAQLPEDIRLE--------VIANREEHL-CIAEYDGYRSPQYPTL 814
            :.|...::.   :|::.:..|.....|..||        ::.||...| ||.:.:       ||.
 Worm   865 RQINFRVANDIDIPEIVKSTLLNGRSDNNLELEDLEDDGLVENRLAELECIIQNE-------PTK 922

  Fly   815 RSPPLLNPYVTT--NVSPLKA 833
            .|...|...::|  |...|.|
 Worm   923 ESVTNLQEMLSTLLNYGKLSA 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351	29/83 (35%)
		PolY_Rev1	218..676	CDD:176455	160/471 (34%)
		Rev1_C	890..985	CDD:213388
rev-1	NP_495663.1	BRCT	255..339	CDD:469589	29/83 (35%)
		PolY_Rev1	381..802	CDD:176455	160/471 (34%)