Protein Alignment Rev1 and DNApol-eta

DIOPT Version :10

• Sequence 1: NP_612047.1
• Gene: Rev1 / 38079
• FlyBaseID: FBgn0035150
• Length: 995
• Species: Drosophila melanogaster
• Sequence 2: XP_321730.6
• Gene: DNApol-eta / 1281773
• VectorBaseID: AGAMI1_004691
• Length: 929
• Species: Anopheles gambiae
• Alignment Length: 749
• Identity: 153/749 - (20%)
• Similarity: 262/749 - (34%)
• Gaps: 239/749 - (31%)

  Fly   269 NCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHS---KGGNAATDVPVHPQADRKAELELFA 330
            |..:|.|:.:|||||:..|..:..|.:||.||||...   :||.
Mosquito    11 NKFDRVVVLVDMDCFYCQVEEKLNPAIRGKPIAVVQYNPWQGGG--------------------- 54

  Fly   331 QRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCP--ELKTIPY- 392
                                        |.:.:|.||.:|:...|...:|.:.||  ||..:|.
Mosquito    55 ----------------------------IIAVNYPARAEGVTRHMRGDEAKQHCPEIELPQVPQV 91

  Fly   393 ----DFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLA----HELN-------------- 435
                |...|:|....:.|.:..:|..:|..|.||.::::|:..    ||:|
Mosquito    92 RGKADLTRYREAGKEVADVLKSFTPLLERASIDEAYLDITERVLTRIHEMNEGKFQLRPEKLANT 156

  Fly   436 --------------------------------------VDV-----MAFVSHLRQEVYSKTGCPC 457
                                                  .|:     .:.|:.:|..|..:||..|
Mosquito   157 FAVGYENIGEFITKLSNTFDPAGGTAESNSQERLEYKKSDIKLLVGASIVNEIRAAVKERTGFEC 221

  Fly   458 SAGVAGNKLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGD 522
            |||:|.||:||::.....|||.|.:| ..|.|......:.|..:.|:|..:..::       |..
Mosquito   222 SAGIAHNKILAKLTAGFHKPNKQTIL-PINSIPKLYETLPLKKVKGLGGKLGDQV-------CEV 278

  Fly   523 VQNTTLEKM----EKVL----GKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIR--FTNS 577
            ::...:.::    |.||    .:::|..::...||||...:..:...|::.....|..:  .|..
Mosquito   279 LKIKFMSELVQFPESVLQQHFEQRMGSWMYLMARGIDLEAVTAKFHSKSIGCCKRFPGKNAITGL 343

  Fly   578 VECEQFLCQLSEEVTKRLV----EIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIINKSSLI 638
            .....:|.:|:.|||:||.    |..|.|:.:.:....:.....|.:::.:           :|:
Mosquito   344 ATLHHWLNELASEVTERLEKDLDENNRTAKQLTVSYSQQIDNVDVSSTRSI-----------ALV 397

  Fly   639 KYATDDVNVITTVVLDLMK----------DADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFG 693
            .|   |...|....||.:|          ......:.::.|||...:.| .|...|...||:||.
Mosquito   398 AY---DAERIAADALDAIKRNTERFFASNSTTALHNPIKFLGISAGKFE-PNGAGKGAGIKQMFQ 458

  Fly   694 KMS-------------EMRK----DKP-----IPQGAVGDK------SIGDDKVNKPLVFENKPK 730
            ..|             |.||    :.|     :|:||...|      ..|:|..|      .:|.
Mosquito   459 SYSSKAANADEPPRETERRKSVSGETPDVVTELPKGAGSSKEEQQQIEKGNDASN------GEPS 517

  Fly   731 PREPR--NVLSMLTAAAVSRKSVTED-------RSQRGTSKPITRPLSLVPKLDEDVLAQLPEDI 786
            ..:.|  :.|...:|.|....|.:|:       .|:..:|:.:.:|.| .||..   :||.   :
Mosquito   518 KLKGRIQHFLQRQSALAPGSTSKSEETGSEAKTASESSSSEEVNQPES-KPKKG---IAQF---L 575

  Fly   787 RLEVIANREEHLCIAEYDGYRSPQYPTLRSPPLLNPYVTTNVSPLKATD--LKPSTSRAAVARLQ 849
            :.:...::|..|...:           ||..|.....:..:..|.|..:  |||.:.      :|
Mosquito   576 QPKCAISKESSLGSGD-----------LRKSPSTVESIEPSAKPKKGIEQFLKPKSD------IQ 623

  Fly   850 KRKE---RKEQEHYIRSDQIVADYIDDLPDFVNP 880
            |..:   .:|:|.....:.....|:||..:...|
Mosquito   624 KESDTGNEQEKEENTNDEAETVPYLDDTVELAVP 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	101/501 (20%)
		Rev1_C	890..985	CDD:213388
DNApol-eta	XP_321730.6	None