DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rev1 and POLI

DIOPT Version :10

Sequence 1:NP_612047.1 Gene:Rev1 / 38079 FlyBaseID:FBgn0035150 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_009126.2 Gene:POLI / 11201 HGNCID:9182 Length:740 Species:Homo sapiens


Alignment Length:811 Identity:168/811 - (20%)
Similarity:313/811 - (38%) Gaps:233/811 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 NCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRF 333
            |...|.::|:|:|||:..|.:.:.|||:..|:.|                           .|::
Human    49 NASSRVIVHVDLDCFYAQVEMISNPELKDKPLGV---------------------------QQKY 86

  Fly   334 EHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTI-PYDFEGY 397
                                    .:.:|:||||:.|::..|.|..|.:.||:|..: ..|...|
Human    87 ------------------------LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRY 127

  Fly   398 KEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDL-------------------AHELN------VD 437
            :|:::.:.:.:.:::..:|.:..||.||:||::                   .|..|      :|
Human   128 REMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLD 192

  Fly   438 VM--------AFVSHLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNG---------QFLLDS 485
            |:        ...:.:|:.:|::.|....||||.|||||::.:...|||.         |.|:.|
Human   193 VLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHS 257

  Fly   486 SNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGI 550
            .|.|..         :||:|...:..|:..|:|:..|:|..:.:.:||.||..:.|.:.:...|.
Human   258 LNHIKE---------IPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGE 313

  Fly   551 DDRPLAYEQIRKTVSAEMNFGIRFTNSVECEQFLCQLSEEVTKRLVEIRRKARSINLKIMVRAAE 615
            |:.|:......::.|.|.:|. :.::.||.:..:.:|...:..|:.:..||..::.|.|...::|
Human   314 DNSPVILSGPPQSFSEEDSFK-KCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSE 377

  Fly   616 APVETSKYMGH--GVCDIINKSSLI-KYATDDVNVITTVVLDLMK------DADIPPDELRGLGI 671
                  |:.|.  ..|.|  .|.:| |..|.:.:|:|.:|..|||      :..:|        .
Human   378 ------KHYGRESRQCPI--PSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMP--------F 426

  Fly   672 HLT-------RLEDANEVRK---------ENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGDDKVN 720
            |||       .|:..|..:|         ..:.....||.|...||..:                
Human   427 HLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHM---------------- 475

  Fly   721 KPLVFENKPKPREPRNVLSMLTAAAVSRKSVTE---DRSQRGTSKPITR-PLSLVPK-LDEDVLA 780
                 |:.||.:|...  ..|.:..:......|   |.:.....|.|.. ||..:|: :|::|..
Human   476 -----EDFPKDKETNR--DFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFK 533

  Fly   781 QLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRSPPLL-------------NP--YVTTNVSP 830
            |||.||:.|:::.:...    ::.|..|...|...|..:|             ||  :::::...
Human   534 QLPVDIQEEILSGKSRE----KFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQV 594

  Fly   831 LKATDLKPSTSRAAVARLQKRKERKEQEHYIRS---DQIVADYIDDLPDF----VNPHILKLISH 888
            ...:..:|.||....:.......:|:..:|:.:   |:.::....:...|    .||.:....|.
Human   595 SSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSF 659

  Fly   889 PVEMPELLMG-----DNYKDLL-------------NDWVSREEVPKPNDVD-LILKQVSRMIKND 934
            |....|.|..     |::|..:             .|.|. |::..|:|:| .:..::...::. 
Human   660 PNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVD-EKITFPSDIDPQVFYELPEAVQK- 722

  Fly   935 QLDHVCDVMKYWCRIINMKRSSSCCWHVAYK 965
                  :::..|      ||:.| .:|:.:|
Human   723 ------ELLAEW------KRAGS-DFHIGHK 740

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rev1NP_612047.1 BRCT_Rev1 39..121 CDD:349351
PolY_Rev1 218..676 CDD:176455 106/465 (23%)
Rev1_C 890..985 CDD:213388 16/95 (17%)
POLINP_009126.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
PolY_Pol_iota 56..437 CDD:176457 104/457 (23%)
DNA-binding. /evidence=ECO:0000269|PubMed:15254543, ECO:0000269|PubMed:27555320, ECO:0007744|PDB:1T3N, ECO:0007744|PDB:5KT2, ECO:0007744|PDB:5KT4, ECO:0007744|PDB:5KT6 249..314 19/73 (26%)
DNA-binding. /evidence=ECO:0000269|PubMed:15254543, ECO:0000269|PubMed:27555320, ECO:0007744|PDB:1T3N, ECO:0007744|PDB:5KT2, ECO:0007744|PDB:5KT4, ECO:0007744|PDB:5KT6 325..439 30/130 (23%)
Ubiquitin-binding 1 (UBM1). /evidence=ECO:0000250|UniProtKB:Q6R3M4 527..544 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 581..615 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..704 5/33 (15%)
Rev1_UBM2 <705..730 CDD:412037 4/37 (11%)
Ubiquitin-binding 2 (UBM2). /evidence=ECO:0000250|UniProtKB:Q6R3M4 708..725 1/23 (4%)
Blue background indicates that the domain is not in the aligned region.

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