DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Reg-2 and DPI35

DIOPT Version :9

Sequence 1:	NP_612043.1	Gene:	Reg-2 / 38075	FlyBaseID:	FBgn0016715	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_013849.1	Gene:	DPI35 / 855160	SGDID:	S000004737	Length:	302	Species:	Saccharomyces cerevisiae

Alignment Length:	249	Identity:	72/249 - (28%)
Similarity:	113/249 - (45%)	Gaps:	41/249 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSRFRLITFDVTNTLLQFRTTPGKQYGEIGALFGARCDNNELAKNFKANWYKMNRDYPNFGRDTN 68
            ::|..:||||..|||...:....:||..:|..:|.:.:.:.|..||...:.|:..|||.:|:.:.
Yeast    18 VARPLIITFDAYNTLYATKLPVMEQYCIVGRKYGIKANPSTLTNNFPHVFKKLKEDYPQYGKYSG 82

  Fly    69 PQMEWQQWWRKLIAGTFAESGAAIPDEKLHNFSNHLIELYKTSICWQPCNGSVELLQQLRKELKP 133
            .:.|  |||..||...||.:  .||||.:    |.::..::....:......::.|:.| |...|
Yeast    83 IKPE--QWWSILIRNVFAPN--EIPDEMI----NEILMRFEGFDSYFVYPDLIKFLKDL-KSRHP 138

  Fly   134 EKCKLGVIANFDPRLPTLLQNTKLDQ------YLDFAINSYEVQAEKPDPQIFQKAMEKSGLKNL 192
            :.. ||:::|.||....||:|..|.:      ||     |||:...|||..|||.|::  .:.:.
Yeast   139 DVI-LGIVSNTDPIFYKLLKNIGLFETFSGHIYL-----SYELNLAKPDRAIFQYALD--DIISK 195

  Fly   193 KP------------EECLHIGDGPTTDYLAAKELGWHSALVHEKSYAYLVKKYG 234
            :|            :.|.||||....|...|:..||...|:....      |||
Yeast   196 QPHLLEKYTREEILQHCFHIGDELKNDLEGAEAAGWTGILLDRND------KYG 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reg-2	NP_612043.1	DREG-2	8..220	CDD:274056	67/229 (29%)
Reg-2	NP_612043.1	HAD_like	76..215	CDD:304363	44/156 (28%)
DPI35	NP_013849.1	DREG-2	23..235	CDD:274056	67/228 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1011
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39934
Inparanoid	1	1.050	85	1.000	Inparanoid score	I1588
Isobase	1	0.950	-	0	Normalized mean entropy	S2956
OMA	1	1.010	-	-		QHG55252
OrthoFinder	1	1.000	-	-		FOG0002375
OrthoInspector	1	1.000	-	-		otm46700
orthoMCL	1	0.900	-	-		OOG6_102573
Panther	1	1.100	-	-	LDO	PTHR46191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1833
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.810