DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Reg-2 and HDHD3

DIOPT Version :9

Sequence 1:	NP_612043.1	Gene:	Reg-2 / 38075	FlyBaseID:	FBgn0016715	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_001291438.1	Gene:	HDHD3 / 81932	HGNCID:	28171	Length:	251	Species:	Homo sapiens

Alignment Length:	249	Identity:	70/249 - (28%)
Similarity:	124/249 - (49%)	Gaps:	28/249 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RFRLITFDVTNTLLQFRTTPGKQYGEIGALFGARCDNNELAKNFKANWYKMNRDYPNFGRDTNPQ 70
            :.||:|:||.:|||:.|...|:.|.......|...:.:.|.:.|:..:...:..:||:|  .:..
Human     6 QIRLLTWDVKDTLLRLRHPLGEAYATKARAHGLEVEPSALEQGFRQAYRAQSHSFPNYG--LSHG 68

  Fly    71 MEWQQWWRKLIAGTF-------AESGAAIPDEKLHNFSNHLIELYKTSICWQPCNGSVELLQQLR 128
            :..:|||..::..||       |::.|.|.::...:||:        ...||..:|:.:.|
Human    69 LTSRQWWLDVVLQTFHLAGVQDAQAVAPIAEQLYKDFSH--------PCTWQVLDGAEDTL---- 121

  Fly   129 KELKPEKCKLGVIANFDPRLPTLLQNTKLDQYLDFAINSYEVQAEKPDPQIFQKAMEKSGLKNLK 193
            :|.:....:|.||:|||.||..:|....|.::.||.:.|......||||:|||:|:.   |.:::
Human   122 RECRTRGLRLAVISNFDRRLEGILGGLGLREHFDFVLTSEAAGWPKPDPRIFQEALR---LAHME 183

  Fly   194 PEECLHIGDGPTTDYLAAKELGWHSAL-VHEKSYAYLVKKYGEDIDRDHVFPSL 246
            |....|:||....||...:.:|.||.| |..::...:|:   :.:.::|:.|||
Human   184 PVVAAHVGDNYLCDYQGPRAVGMHSFLVVGPQALDPVVR---DSVPKEHILPSL 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reg-2	NP_612043.1	DREG-2	8..220	CDD:274056	63/218 (29%)
Reg-2	NP_612043.1	HAD_like	76..215	CDD:304363	42/145 (29%)
HDHD3	NP_001291438.1	DREG-2	8..210	CDD:274056	63/218 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143355
Domainoid	1	1.000	45	1.000	Domainoid score	I12263
eggNOG	1	0.900	-	-		E1_COG1011
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2956
OMA	1	1.010	-	-		QHG55252
OrthoDB	1	1.010	-	-		D1119971at2759
OrthoFinder	1	1.000	-	-		FOG0002375
OrthoInspector	1	1.000	-	-		otm40885
orthoMCL	1	0.900	-	-		OOG6_102573
Panther	1	1.100	-	-	LDO	PTHR46191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1833
SonicParanoid	1	1.000	-	-		X2471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700