DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hipk and DYRK2

DIOPT Version :10

Sequence 1:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_006473.2 Gene:DYRK2 / 8445 HGNCID:3093 Length:601 Species:Homo sapiens


Alignment Length:575 Identity:174/575 - (30%)
Similarity:256/575 - (44%) Gaps:104/575 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PKASDFVDYAVAGGGGSGF-----CSGLGAGLS----------------VRATSFYGDQTVTATT 50
            |.|:....|....||.|..     ..|||||.:                :||::   ......|.
Human     6 PSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASN---AAAAAHTI 67

  Fly    51 DGTRH--------------QEQQQQQLQQQQQQH--ILRQPATSASTSSVAAAATSKRKRQTDCD 99
            .|::|              |.|.||..:....:.  :..||....:..........:|:      
Human    68 GGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQ------ 126

  Fly   100 CGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQP 164
               :||.:...|......|....|      |..:.|    :.|..::|....|:.....|.....
Human   127 ---LDSIHRRQGSSTSLKSMEGMG------KVKATP----MTPEQAMKQYMQKLTAFEHHEIFSY 178

  Fly   165 P---------SKR-------SSSGAD---GDYQLVQHE-VLYSLSAEYEVLEFLGRGTFGQVVKC 209
            |         .||       ::.|.|   |.|..|.|: |.|    .||||:.:|:|:||||||.
Human   179 PEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAY----RYEVLKVIGKGSFGQVVKA 239

  Fly   210 WKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENADE-FNFVRAFECFQHKNHTCLVFEML 273
            :.....:.||:|:::|...:.||...|:.||..|.:::.|. .|.:...|.|..:||.|:.||:|
Human   240 YDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELL 304

  Fly   274 EQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVI 338
            ..|||:.:|:|||....|..:|.....:|..|..|.:..:||.|||||||:|....|.  .:|||
Human   305 SMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRS--GIKVI 367

  Fly   339 DFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQI 403
            ||||:.:..:.| .||:|||:|||||:|||..:...||||||||::|||..|:||.||..|.||:
Human   368 DFGSSCYEHQRV-YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQL 431

  Fly   404 RYISQTQGLPTEHMLNSASKTSKFFYRDVDST-YPFWRLKTTEEHEAETNTKSKEARKYIFNCLD 467
            ..:.:..|:|::.:|: |||.:|.|   |.|. ||.:...||....:......:..|        
Human   432 ACMIELLGMPSQKLLD-ASKRAKNF---VSSKGYPRYCTVTTLSDGSVVLNGGRSRR-------- 484

  Fly   468 DIGQVNVPTD-LEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTR 521
              |::..|.: .|.|..| :..|...|:|.||:.|..|...|:||.:||.|.:.|
Human   485 --GKLRGPPESREWGNAL-KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 128/330 (39%)
PHA03378 <1080..1327 CDD:223065
DYRK2NP_006473.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 6/17 (35%)
PKc_DYRK2_3 156..535 CDD:271126 143/400 (36%)
Nuclear localization signal. /evidence=ECO:0000305|PubMed:19965871 189..191 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

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