DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hipk and DYRK3

DIOPT Version :10

Sequence 1:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_003573.2 Gene:DYRK3 / 8444 HGNCID:3094 Length:588 Species:Homo sapiens


Alignment Length:527 Identity:155/527 - (29%)
Similarity:228/527 - (43%) Gaps:111/527 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 LSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTD 97
            |::....|.||.|......|....||..|:...::...|    .:...:.|...:.|..:.:.:|
Human    62 LNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTI----QSDGISDSEKCSPTVSQGKSSD 122

  Fly    98 CDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLK------TAHTKVA-- 154
            | ...|.|.:||..|.|..                       :.|..:||      ||:.|:.  
Human   123 C-LNTVKSNSSSKAPKVVP-----------------------LTPEQALKQYKHHLTAYEKLEII 163

  Fly   155 -----------TSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVK 208
                       ....|.....|:......|||.|..|..:   .|:..||||:.:|:|:||||.:
Human   164 NYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD---HLAYRYEVLKIIGKGSFGQVAR 225

  Fly   209 CWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRL-SQENADEFNFVRAFECFQHKNHTCLVFEM 272
            .:.....:.||:|:::|...:.||...|:.||..| .|:.....|.:...|.|..:||.|:.||:
Human   226 VYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFEL 290

  Fly   273 LEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKV 337
            |..:||:.:|:|||....::.:|...:.:|.:|..|.:..:||.|||||||:|....|.  ..||
Human   291 LSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--STKV 353

  Fly   338 IDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQ 402
            |||||:....:.: .||:|||:|||||||||..:...||:||.||::|||..|.||:||..|.||
Human   354 IDFGSSCFEYQKL-YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQ 417

  Fly   403 IRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLD 467
            :..:.:..|:|...:|.. ||.:|:|                        ..||...:|   |  
Human   418 LACMMELLGMPPPKLLEQ-SKRAKYF------------------------INSKGIPRY---C-- 452

  Fly   468 DIGQVNVPTDLEGGQLLAEKTDRRE----------------------FIDLLKRMLTIDQERRLT 510
                 :|.|..:|..:|.....||.                      ||:.|||.|..|...|||
Human   453 -----SVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLT 512

  Fly   511 PAEALNH 517
            ||:||.|
Human   513 PAQALRH 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 121/349 (35%)
PHA03378 <1080..1327 CDD:223065
DYRK3NP_003573.2 Disordered. /evidence=ECO:0000305|PubMed:23415227 1..188 28/153 (18%)
PKc_DYRK2_3 143..522 CDD:271126 135/418 (32%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:29973724 468..481 2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

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