Protein Alignment Hipk and hipk3a

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_021326179.1
• Gene: hipk3a / 564413
• ZFINID: ZDB-GENE-061207-54
• Length: 1248
• Species: Danio rerio
• Alignment Length: 1350
• Identity: 490/1350 - (36%)
• Similarity: 636/1350 - (47%)
• Gaps: 344/1350 - (25%)

  Fly    69 QHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGS 133
            |.:||:    ||:.....|:..|.:..:..:.|.             ::.|..:|..|.||...|
Zfish    84 QELLRR----ASSPYNRVASEGKLQYFSKAEVGV-------------EEKSGDSGQNSQGSSRSS 131

  Fly   134 GPGPDGI------GPISS------------------------LKTAH--------TKVATSGGHA 160
            |..|:|:      |.::|                        :...|        |.|.::....
Zfish   132 GGAPEGVRRKERSGGLNSDEGTQKCGFKCKGQEIENSKSIMQIVEEHSTLPAMLPTNVGSTTAVG 196

  Fly   161 NTQPPSKRSSSGA-----DGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAI 220
            ...|..|.:.:||     ||||||||||||.|:...|||||||||||||||||||||||:||||:
Zfish   197 VAPPEQKGTGTGAVNGTGDGDYQLVQHEVLCSMKHTYEVLEFLGRGTFGQVVKCWKRGTNEIVAV 261

  Fly   221 KILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNK 285
            ||||||||||||||||||||:|||.|||:|.|.|||||||||::|||||||||||||||||||||
Zfish   262 KILKNHPSYARQGQIEVSILARLSGENAEEHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQNK 326

  Fly   286 FSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTV 350
            |||||||.|||:|:||.|||.|||.||||||||||||||||||||||:|||||||||||||||.|
Zfish   327 FSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPFRVKVIDFGSASHVSKAV 391

  Fly   351 CNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTE 415
            |:|||||||||||||||||||||||||||||||:||||||||||||:.|:|||||||||||||.|
Zfish   392 CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE 456

  Fly   416 HMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEG 480
            .:||..:||::||.::.||.|..|||||||||||||..||||||||||:||||||.||:..::||
Zfish   457 QLLNVGTKTARFFCKESDSPYTAWRLKTTEEHEAETGLKSKEARKYIFSCLDDIGHVNLMLNMEG 521

  Fly   481 GQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVC- 544
            ...||||.|||||:||||.||.||.::|:.|::||.|.|..:.||:|:.:||:|::...:|:||
Zfish   522 CDQLAEKADRREFVDLLKMMLMIDADQRIAPSDALTHPFVTMQHLMDFPHCNHVQSCFHIMDVCH 586

  Fly   545 -RRGDFHTV--QPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSV 606
             |...|.|:  ..|..|:......|..|:|...|...:...|.|.....|:.:.|: .|..|
Zfish   587 LRTSIFDTLNRNKAPPLMKPVTLPSAPNITVAFNKMPSVHSQTLPPSAPPVVHPGI-PIQTG--- 647

  Fly   607 ARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVP----V 667
            :.|:  ...:|||..|   |||||:.|.:||........|..|:..:.:..|.....|:|    |
Zfish   648 SAQF--GCNESFQQAL---ILCPPAMQGIPSNPNQPAGYSVRMENTIPLVTQAPAIQPLPMRPGV 707

  Fly   668 SMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHL 732
            ...:|.|       ||.       ||     .|||:|.|..|
Zfish   708 IAQQPWS-------NRT-------PQ-----ILVPAWQQVPP----------------------- 730

  Fly   733 NLPRNDLKKESPAHHIAKGN-----SYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVS 792
              |...|..::......:|:     :...|....:..|....|:        ||...|   :.|.
Zfish   731 --PATSLASDTVVGAQRRGDWGTTGTTAFPCLVLETKQMCWKVR--------PHSSHY---SSVM 782

  Fly   793 PQ--------YHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAH----- 844
            ||        ..||...|.|        ...||....||     |..:..|.:..:.|:|
Zfish   783 PQPIVPNQMAVSAHQPINIG--------IAHVVWPQPAS-----NKRNKPSQNRSMNVSHFTDTQ 834

  Fly   845 ---------------AQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQH 894
                           .:|.:||                        |..|.|...:|...|:.:.
Zfish   835 PSVCPSPKMPEMLPSVEPQTSS------------------------PERAVQAQVKQEPKQTEEE 875

  Fly   895 PQHVK-------QPTITIHDTPSP-TAVITISDSEDEGGE-AGGAQVPVLKQRAHAQSQTSGSL- 949
            ....|       :.:|.|.::||| .:||:||...||..| |....:...|.....::.| |||
Zfish   876 ESCCKTTVPNKQRESIIIRESPSPAVSVISISSGTDEEEEQAQRCSLNKCKGSPECEACT-GSLN 939

  Fly   950 ------LQHAPSSSCSRSSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHH 1008
                  |....||..:.|||..|..|.| .::...|:..|        .|.:......|||....
Zfish   940 MERVCSLSSPDSSLSTSSSASAQSSPSP-CKRPSSISEDD--------GHESGCETVDGSPPSDS 995

  Fly  1009 ----HQQQQQPAPPPQQ-----QQQQYQPQP--------------------PPQQVLPQPQPSIK 1044
                |:     :|.|::     |.|..:|:.                    ||.:||     :..
Zfish   996 SLGPHE-----SPFPERRFLRNQNQNQEPRARRGHPNNTGLNKPAVRTVVVPPMRVL-----NNN 1050

  Fly  1045 YEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQE-PAEFYPE-YAAAPPQQLDTKR 1107
            :.| .::...|..:.:|.|..:.:......|..|.|.:|.:|: .:.|.|: ......|...:..
Zfish  1051 HHP-NNEHLAISTVFESSCQSRSRCGPGRLSHLSTPTLPRQQKLSSSFQPQPLGFGQVQHYGSCH 1114

  Fly  1108 SSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSV-AP--PLAHSKSSSASSSSSISAATAAA 1169
            ..|    :|:      ...|:|      |.:::.|:| .|  ||.|...:.::..
Zfish  1115 KEW----NGN------YRQPRR------PQAFIPPTVHGPTFPLPHGSPTHSAGH---------- 1153

  Fly  1170 AAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHP-HHHSHGHHHHQAGT 1233
                        ||   ||.:...|...|...: || |..|||   ||.| ...::...||| |.
Zfish  1154 ------------PP---PPALLSYPPSAPVAHL-LP-SPCPPP---APRPVLQPAYSLVHHQ-GI 1197

  Fly  1234 PLGGS----PSSTAA-----AALLQPDIYAQGDIYRRPTVFVSQAAPSYA 1274
            .:|.:    ||.|..     .||..|..|.              |:|:||
Zfish  1198 SMGINHRLLPSPTLLPQGQFKALFPPHSYV--------------ASPAYA 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	265/327 (81%)
		PHA03378	<1080..1327	CDD:223065	47/209 (22%)
hipk3a	XP_021326179.1	Protein Kinases, catalytic domain	232..561	CDD:473864	265/328 (81%)